Molecular epidemiology and prevalence of babesial infections in dogs in two hyperendemic foci in Brazil

Dantas‐Torres, Filipe; Alexandre, Joanna; Miranda, Débora Elienai de Oliveira; Figueredo, Luciana Aguiar; Sales, Kamila Gaudêncio da Silva; Sousa‐Paula, Lucas Christian de; Silva, Lidiane Gomes da; Valle, Guilherme Ribeiro; Ribeiro, Vítor Márcio; Otranto, Domenico; Deuster, Katrin; Pollmeier, Matthias; Altreuther, Gertraut

doi:10.1007/s00436-021-07195-8

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…This may be due to the shorter time of circulation of B. vogeli in the blood of infected animals. Epidemiological data from previous studies demonstrated that B. vogeli is highly prevalent in Brazil, with up to 8.2% molecularly positive dogs in Pernambuco (Ramos et al 2010 ; Dantas-Torres et al 2021 ), 8.0% in São Paulo (O’Dwyer et al 2009 ), 10.0% in Paraíba (Rotondano et al 2015 ), 15.0% in Ceará (Fonsêca et al 2022 ), 30.6% in Minas Gerais (Barbosa et al 2020 ) and 14.1% in Rio de Janeiro (Paulino et al 2018 ; Camilo et al 2021 ). Conversely, H. canis has been reported with lower prevalence (i.e., 0.4% to 5.4%) in Northeastern Brazil (Ramos et al 2010 ; Dantas-Torres et al 2021 ), differently from the Southeastern region, in which higher prevalence values (i.e., 58.7–79.2%) were reported (Miranda et al 2014 ; Spolidorio et al 2009 ).…”

Section: Discussionmentioning

confidence: 99%

Vector-borne pathogens of zoonotic concern in dogs from a Quilombola community in northeastern Brazil

et al. 2022

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Canine vector-borne pathogens (CVBPs) comprise a group of disease agents mainly transmitted by ticks, fleas, mosquitoes and sand flies. In this study, we assessed the presence of CVBPs in an Afro-descendent community (Quilombola) of northeastern, Brazil. Dog blood samples (n = 201) were collected and analyzed by rapid test for the detection of antibodies against Leishmania spp., Anaplasma spp., Ehrlichia spp. and Borrelia burgdorferi sensu lato (s.l.), and antigens of Dirofilaria immitis. In addition, polymerase chain reactions were performed for Anaplasmataceae, Babesia spp., Hepatozoon spp., Rickettsia spp. and B. burgdorferi s.l. Overall, 66.7% of the dogs scored positive to at least one pathogen at serological and/or molecular methods. Antibodies against Ehrlichia spp. were the most frequently detected (57.2%; n = 115/201), followed by Anaplasma spp. (8.5%; n = 17/201), Leishmania spp. (8.5%; n = 17/201) and B. burgdorferi s.l. (0.5%; n = 1/201). For D. immitis, 11 out of 201 (5.5%) animals scored positive. At the molecular analysis, 10.4% (n = 21/201) of the samples scored positive for Babesia spp./Hepatozoon spp., followed by Anaplasmataceae (5.0%; n = 10/201) and Rickettsia spp. (3.0%; n = 6/201). All samples were negative for B. burgdorferi s.l. Our data demonstrated the presence of CVBPs in the studied population, with a high seropositivity for Ehrlichia spp. In addition, considering the detection of zoonotic pathogens in dogs and their relationship with people from Quilombola communities, effective control strategies are advocated for minimizing the risk of infection in this socially vulnerable human population and their pets.

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Section: Discussionmentioning

confidence: 99%

Vector-borne pathogens of zoonotic concern in dogs from a Quilombola community in northeastern Brazil

et al. 2022

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Molecular detection of vector-borne pathogens in semen from dogs in southeastern Brazil

Valle

Ribeiro²,

Teles

et al. 2022

Veterinary Parasitology: Regional Studies and Reports

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Dogs’ general response to babesiosis infection of various severities

Bilokur,

Semenko,

Gryshchenko

2023

Ukrainian journal of veterinary sciences

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Global climate change in recent decades has led to an increase in the activity and expansion of the range of many diseases. One of them is canine babesiosis. Therefore, it is becoming increasingly important to monitor the functional state of the organism in sick dogs and timely detection of kidney, liver, spleen, cardiovascular system, anaemia, and other disorders that complicate the course of babesiosis. The research aims to determine the peculiarities of metabolic and functional changes in dogs with different intensities of babesiosis infection. During the laboratory diagnostics, general and special research methods were used: light microscopy, centrifugation, spectrophotometry, and mathematical statistics. Based on the results of comprehensive microscopic, morphological, and biochemical studies of blood in dogs with different intensities of babesiosis infection, the most characteristic functional and metabolic changes in their body were identified. Thus, at different intensities of babesiosis infection in diseased animals, the features of the haematological profile are leukocytopenia against the background of eosinopenia (at a mild degree of infection) and lymphocytopenia with a simultaneous compensatory increase in the number of monocytes and neutrophils, as well as erythrocytopenia, hypochromemia, thrombocytopenia with a decrease in thrombocrit and haematocrit. In addition, these patients developed hyperfermentemia of aspartate and alanine aminotransferases, alkaline phosphatase, and γ-glutamyl transpeptidase, indicating structural and functional changes, primarily in the myocardium, liver, skeletal muscle, brain and kidneys due to their toxic damage by babesia waste products. At the same time, hypoproteinaemia, hypoalbuminemia and hyperazotemia were observed in the affected animals, indicating an increase in the intensity of catabolic processes in functional cells of organs and tissues, especially the liver. The most pronounced changes in the studied parameters were observed at high intensity of babesiosis infection. The established regularities allow the use of these haematological parameters as markers of functional and metabolic changes in the body of dogs at different intensities of babesiosis infection

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Molecular epidemiology and prevalence of babesial infections in dogs in two hyperendemic foci in Brazil

Cited by 3 publications

References 26 publications

Vector-borne pathogens of zoonotic concern in dogs from a Quilombola community in northeastern Brazil

Vector-borne pathogens of zoonotic concern in dogs from a Quilombola community in northeastern Brazil

Molecular detection of vector-borne pathogens in semen from dogs in southeastern Brazil

Dogs’ general response to babesiosis infection of various severities

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