Molecular effects of genistein on estrogen receptor mediated pathways

Wang, Thomas T.Y.; Sathyamoorthy, Neeraja; Phang, James M.

doi:10.1093/carcin/17.2.271

Cited by 450 publications

(287 citation statements)

References 11 publications

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“…30 -32 Dietary soy supplementation has been correlated with lower plasma estradiol concentrations 33,34 and soy phytoestrogens are known, among other actions, to compete with endogenous 17␤-estradiol for estrogen receptors. 35,36 Although the lung has not traditionally been considered a target for female hormones, 2 previous studies 7,37 both in Chinese women, have reported an increased risk of lung adenocarcinoma associated with shorter menstrual cycles, implicating hormones as possible factors. Reproductive events are known to modulate plasma estrogen levels; inverse associations have been demonstrated between estrogen levels and parity and age at first birth.…”

Section: Discussionmentioning

confidence: 99%

Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: Evidence for a protective effect of soy in nonsmokers

Seow

Poh

Teh

et al. 2001

Intl Journal of Cancer

106

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The factors associated with risk of lung cancer among nonsmokers have not been fully elucidated, but dietary factors have consistently been shown to play a role. Chinese women are unique in having a high incidence of lung cancer despite a low smoking prevalence. This population is also known to have a high intake of soy, a dietary source of phytoestrogens. We conducted a hospital-based case-control study among Singapore Chinese women, comprising 303 cases and 765 age-matched controls, of whom 176 cases and 663 controls were lifetime nonsmokers. Data on demographic background, reproductive factors and dietary intake of fruit, vegetables and soy foods were obtained by in-person interview. We observed an inverse association between intake of total, cruciferous and non-cruciferous vegetables and risk of lung cancer among smokers. Although smokers in the highest tertile of fruit intake also had a lower risk, this was not statistically significant. Higher intake of soy foods significantly reduced risk of lung cancer among lifetime nonsmokers, but not among smokers. When soy isoflavonoid intake in mg/week was computed based on frequency and portion size of intake of eight common local soy foods, the adjusted OR among nonsmokers for the highest tertile compared to the lowest was 0.56, 95% CI 0.37-0.85 (p for trend <0.01). Fruit intake was also significantly associated with reduced lung cancer risk among nonsmokers, but the effect was not significant after adjustment for soy intake. On the other hand, soy intake remained an independent predictor of risk after controlling for fruit intake. Reproductive effects were also primarily confined to lifetime nonsmokers, among whom having 3 or more livebirths (adjusted OR 0.65, 0.44 -0.96) and a menstrual cycle length of more than 30 days (OR 0.46, 0.25-0.84) accorded a significantly reduced risk of lung cancer. Place of birth was significantly associated with risk among nonsmokers (OR 2.6, 1.7-3.9 for China-born vs. local born) but not among smokers. When analysis was restricted to nonsmokers with adenocarcinomas, the dietary effects were consistent or enhanced. On stepwise regression, soy intake and cycle length emerged as the independent dietary and reproductive predictors of lung cancer risk in nonsmokers. These findings are consistent with other evidence suggesting an involvement of estrogen-related pathways in lung cancer among non-smoking women.

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Section: Discussionmentioning

confidence: 99%

Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: Evidence for a protective effect of soy in nonsmokers

Seow

Poh

Teh

et al. 2001

Intl Journal of Cancer

106

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“…Soy isoflavones also act independently of the ER: they exhibit anti-proliferative, anti-oxidant, and anti-inflammatory properties in vivo and in vitro (Guha et al, 2009). However, soy isoflavones exhibit only weak estrogenic activity: daidzein has 10-4 the activity per mole as 17β-estradiol (Wang et al, 1996;Santell et al, 1997). These anti-estrogenic effects by soy food intake may play a positive role in the better breast cancer outcomes (Shu et al, 2009;Zhang et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Post-diagnosis Soy Food Intake and Breast Cancer Survival: A Meta-analysis of Cohort Studies

Chi

Wu²,

Zeng³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background and Objectives: Data on associations between soy food intake after cancer diagnosis with breast cancer survival are conflicting, so we conducted this meta-analysis for more accurate evaluation. Methods: Comprehensive searches were conducted to find cohort studies of the relationship between soy food intake after cancer diagnosis and breast cancer survival. Data were analyzed with comprehensive meta-analysis software.

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“…The estrogenic activity of genistein and coumestrol in plants has also been established, although their beneficial effects such as preventing breast cancer have also attracted interest in these compounds [31,32]. Recently many persistent environmental chemicals including pesticides, plastic ingredients, and combustion by-products have been found to have estrogenic activity.…”

Section: Discussionmentioning

confidence: 99%

Growth Stimulation of a Rat Pituitary Cell Line MtT/E-2 by Environmental Estrogens in vitro and in vivo.

et al. 1999

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Abstract.Endocrine disruptors are a diverse group of chemicals that alter the functions of the endocrine system. A large proportion of endocrine disruptors have estrogenic effects, thus are called environmental estrogens. In the present study, an estrogen (E2) responsive rat pituitary cell line, MtT/E-2, was employed to examine 1) the potency of several endocrine disruptors including bisphenol A (BPA), o,p'-DDD, methoxychlor, 1,2,3,4,5,6-hexachlorocyclohexane (HCH) and dibromoacetic acid (DBAA) in terms of E2 responsive pituitary cell growth; 2) whether BPA has estrogenic action in vivo causing the growth of MtT/E-2 cells grafted in rats. Binding assays showed the test chemicals were able to compete with 3H-E2 binding to the estrogen receptor (ER). The compounds also stimulated growth of MtT/E-2 cells at rates corresponding to their ER binding affinity. Their transcription activation of an (ERE)3-SV40-luciferase reporter in MtT/E-2 cells was comparable to their stimulation of cell growth, with the exception of HCH which showed little induction of cell growth but strong stimulation in ERE dependent transcription activation.MtT/E-2 cells were inoculated into ovariectomized female F344 rats treated with E2 or BPA. The first tumors were noted at day 22 in the E2 treated group, at day 25 in the highest dose of BPA group and at day 41 in the control group. These results suggest 1) that the growth assay with MtT/E-2 cells provides simple and sensitive test for detection of estrogenic activity of environmental chemicals; 2) that BPA has estrogenic potency to stimulate E2 responsive cell growth in vivo as well as in vitro.

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Molecular effects of genistein on estrogen receptor mediated pathways

Cited by 450 publications

References 11 publications

Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: Evidence for a protective effect of soy in nonsmokers

Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: Evidence for a protective effect of soy in nonsmokers

Post-diagnosis Soy Food Intake and Breast Cancer Survival: A Meta-analysis of Cohort Studies

Growth Stimulation of a Rat Pituitary Cell Line MtT/E-2 by Environmental Estrogens in vitro and in vivo.

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