volume 85, issue 5, P827-842 2017
DOI: 10.1002/prot.25235
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Abstract: AbstractHuman group IIA phospholipase A 2 (hGIIA) promotes inflammation in immune-mediated pathologies by regulating the arachidonic acid pathway through both catalysis-dependent and -independent mechanisms. The hGIIA crystal structure, both alone and inhibitor-bound, together with structures of closely related snake-venom-derived secreted phospholipase enzymes has been well described. However, differentiation of biological and non-biological contacts and the relevance of structures determined from snake veno…

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