Molecular Docking studies on possible Neuraminidase Inhibitors of Influenza Virus

Abstract

Background: Infl uenza generally known as fl u is due to viruses that contaminate the respiratory region. It can result in light to cruel sickness, and may cause death. The infl uenza pandemic of 1918-1919 took life of a lot more people than the World War 1. Peramivir that inhibits the purpose of the viral neuraminidase protein of infl uenza virus, therefore stopping the virus from replicating through budding from the host cell has been shown to have hindrance against virus. The neuraminidase enzyme is a glycoside hydrolyses enzyme that is shown on the exterior. It allows the virus to be free from the host cell and slice sialic acid groups from glycoproteins and is necessary for infl uenza virus reproduction. Methods: This study concentrates on the in silico virtual screening and molecular docking examination for probable neuraminidase blockers by peramivir like compounds recovered by the ZINC database. ADME-Toxicity examination is done by in silico methods. Results: Molecular docking outcomes propose that modifi ed ligand Anamivire have improved binding attraction than peramivir and its derivatives i.e. ZINC3981610, ZINC 40709762. Conclusion: Modifi ed ligand Anamivire is shown to have resistance against neuraminidase enzyme and bioavailability troubles than ZINC3981610, ZINC40709762 and peramivir.

RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks

“…Although molecular docking analysis is available for the identification of various drug molecules with avian influenza virus ( Amir et al, 2011 ; Liu et al, 2015 ; Khan et al, 2017 ; Pal and Chakravarty, 2019b ), this is the first report of molecular docking analysis with the immune response molecules responsible for antiviral immunity against avian influenza and is the basis for finding drug for a disease. A series of immune response molecules are responsible for providing antiviral immunity with their respective interaction in various pathways as we depicted through String and KEGG pathway analyses in our current study.…”