Biochemical Pharmacology volume 81, issue 6, P723-735 2011 DOI: 10.1016/j.bcp.2010.12.026 View full text
Serkan Sertel, Yujie Fu, Yuangang Zu, Blanka Rebacz, Badireenath Konkimalla, Peter K. Plinkert, Alwin Krämer, Jürg Gertsch, Thomas Efferth

Abstract: Vinblastine and vincristine are dimeric indole alkaloids derived from Catharanthus roseus (formerly: Vinca rosea). Their monomeric precursor molecules are vindoline and catharanthine. While vinblastine and vincristine are well-known mitotic spindle poisons, not much is known about vindoline and catharanthine. Vindoline and catharanthine showed weak cytotoxicity, while vinblastine, vincristine, and the semisynthetic vindesine and vinorelbine revealed high cytotoxicity towards cancer cells. This may reflect a ge…

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