volume 278, issue 26, P23666-23671 2003
DOI: 10.1074/jbc.m302493200
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Abstract: We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcAT-II) and N-acetylgalactosaminyltransferase-II (GalNAcT-II) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy. We report here that the chondroitin polymerizing activity requires concomitant expression of a novel protein designated chondroitin polymerizing factor (ChPF) with ChS…

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