1993
DOI: 10.1161/01.res.73.3.413
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Abstract: Increasing evidence suggests that angiotensin II (Ang II) may act as a growth factor for the heart. However, direct effects of Ang II on mammalian cardiac cells (myocytes and nonmyocytes), independent of secondary hemodynamic and neurohumoral effects, have not been well characterized. Therefore, we analyzed the molecular phenotype of cultured cardiac cells from neonatal rats in response to Ang II. In addition, we examined the effects of selective Ang II receptor subtype antagonists in mediating the biological … Show more

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Cited by 1,192 publications
(741 citation statements)
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References 47 publications
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“…of 2 µM and complete inhibition at 30 µM (results not shown). As shown in Figures 2(A) and 2(B), both Ang II (2.3p0.3-fold ; P 0.05 compared with control) and phenylephrine (3.7p0.6-fold ; P 0.05 compared with control) induced the expression of ANF mRNA, confirming previous observations [37,38]. Treatment of myocytes with 30 µM PD98059 caused a small suppression of basal expression of ANF mRNA (0.8p0.1-fold), and complete inhibition of Ang II-induced ANF expression (0.9p0.1-fold ; not significant), whereas it had little effect on phenylephrine-induced ANF expression (3.7p0.5-fold ; P 0.05 compared with control).…”
Section: Effects Of Pd98059 and Sb203580 On Ang Ii-or Phenylephrineinsupporting
confidence: 89%
See 1 more Smart Citation
“…of 2 µM and complete inhibition at 30 µM (results not shown). As shown in Figures 2(A) and 2(B), both Ang II (2.3p0.3-fold ; P 0.05 compared with control) and phenylephrine (3.7p0.6-fold ; P 0.05 compared with control) induced the expression of ANF mRNA, confirming previous observations [37,38]. Treatment of myocytes with 30 µM PD98059 caused a small suppression of basal expression of ANF mRNA (0.8p0.1-fold), and complete inhibition of Ang II-induced ANF expression (0.9p0.1-fold ; not significant), whereas it had little effect on phenylephrine-induced ANF expression (3.7p0.5-fold ; P 0.05 compared with control).…”
Section: Effects Of Pd98059 and Sb203580 On Ang Ii-or Phenylephrineinsupporting
confidence: 89%
“…The RNA was resolved by electrophoresis on 1 % (w\v) agarose gels and transferred to nitrocellulose membranes. The probes for c-fos, ANF, and skeletal α-actin (SKA) were used as described previously [37].…”
Section: Analysis Of Mrnamentioning
confidence: 99%
“…In this regard, one heterotrimeric G-protein, G␣q, contributes to the onset of cardiac hypertrophy triggered by seven-transmembrane receptors (Minamino et al, 2002). Some factors, including Angiotensin II, endothelin, and adrenergic agonists are known to induce this type of hypertrophy (Simpson, 1983;Shubeita et al, 1990;Sadoshima and Izumo, 1993;Glennon et al, 1995). MEKK1 knockout mice and cardiac myocytes derived from these animals are resistant to G␣q-mediated hypertrophic response (Minamino et al, 2002).…”
Section: Mekk1 (Omim#*600982)mentioning
confidence: 99%
“…Our and other laboratories have recently reported that Ang II increases the activity of Raf-1 and MAP kinases, and mRNA levels of c-fos through the AT1 receptor in cardiac myocytes [7,8]. To elucidate the relation between signaling pathways that induce the activation of p70 s6~ and MAP kinases, we measured the activity of MAP kinases after Ang II stimulation in the presence or absence of rapamycin.…”
Section: P70 S6r Activation Is Independent Of Map Kinase Activation Amentioning
confidence: 99%
“…Many lines of evidence have suggested that angiotensin II (Ang II) plays a critical role in inducing cardiac hypertrophy [1][2][3][4][5][6][7]. All components of the renin angiotensin system such as renin, angiotensinogen and angiotensin-converting enzyme (ACE) have been identified in the heart at both mRNA and protein levels [5,6].…”
Section: Introductionmentioning
confidence: 99%