Molecular characterization of a novel ovodefensin gene in chickens

Yu, Ling; Xiao, Yingping; Li, Jingjing; Ran, Jin-Shan; Yin, Lingqian; Liu, Yiping; Zhang, Long

doi:10.1016/j.gene.2018.08.029

Cited by 20 publications

(11 citation statements)

References 41 publications

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“…IFIT5 confers antiviral defense by disrupting protein-protein interactions in the host translation initiation machinery [16], and its expression is induced in ducks upon infection with influenza virus [17]. The selective sweep of genes involved in lipid and glucose metabolism and immune defense [18, 19] may be responsible for the dramatic phenotypic changes that are of economic value in domestic chickens, such as meat yield and disease resistance. SLC16A12 is a member of the carboxylic acid transporter family, essential for the establishment and/or maintenance of homeostasis in the lenses and kidneys.…”

Section: Resultsmentioning

confidence: 99%

Population genomics identifies patterns of genetic diversity and selection in chicken

et al. 2019

BMC Genomics

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Background There are hundreds of phenotypically distinguishable domestic chicken breeds or lines with highly specialized traits worldwide, which provide a unique opportunity to illustrate how selection shapes patterns of genetic variation. There are many local chicken breeds in China. Results Here, we provide a population genome landscape of genetic variations in 86 domestic chickens representing 10 phenotypically diverse breeds. Genome-wide analysis indicated that sex chromosomes have less genetic diversity and are under stronger selection than autosomes during domestication and local adaptation. We found an evidence of admixture between Tibetan chickens and other domestic population. We further identified strong signatures of selection affecting genomic regions that harbor genes underlying economic traits (typically related to feathers, skin color, growth, reproduction and aggressiveness) and local adaptation (to high altitude). By comparing the genomes of the Tibetan and lowland fowls, we identified genes associated with high-altitude adaptation in Tibetan chickens were mainly involved in energy metabolism, body size maintenance and available food sources. Conclusions The work provides crucial insights into the distinct evolutionary scenarios occurring under artificial selection for agricultural production and under natural selection for success at high altitudes in chicken. Several genes were identified as candidates for chicken economic traits and other phenotypic traits. Electronic supplementary material The online version of this article (10.1186/s12864-019-5622-4) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Population genomics identifies patterns of genetic diversity and selection in chicken

et al. 2019

BMC Genomics

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“…All primer sequences (Table S1) were designed using Primer 5.0 software and were synthesized by Biosune Biotechnology. The thermal cycling conditions used were as follows: 94°C for 30 s, followed by 40 cycles of denaturation at 94°C for 5 s, annealing at 60°C for 31 s, and 72°C for 10 s. The specificity of the PCR reaction was confirmed through melting curve and sequencing analysis (L. Yu et al, 2018). qPCR was performed on an ABI 7300 (Applied Biosystems) using SYBR Premix Ex Taq II (Tli RNaseH Plus; TaKaRa).…”

Section: Methodsmentioning

confidence: 99%

Transcriptome analyses to reveal the dynamic change mechanism of pigeon magnum during one egg‐laying cycle

Liu

et al. 2020

Molecular Reproduction Devel

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We analyzed the transcriptome of pigeon magnum in three stages (C1: preovulation, C2: post-ovulation, C3: 5-6 days after ovulation) to elucidate the molecular and cellular events associated with morphological changes during the laying cycle. We observed that C1 was highly developed, apoptosis rate was highest in C2, and C3 attained the smallest size. Through RNA-sequencing, we obtained SUPPORTING INFORMATION Additional supporting information may be found online in the Supporting Information section. How to cite this article: Lu L, Xu X, Du X, et al. Transcriptome analyses to reveal the dynamic change mechanism of pigeon magnum during one egg-laying cycle.

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“…Total genomic DNA was isolated with the TIANamp Blood DNA Kit in accordance with the manufacturer's instructions, and then stored at − 20°C, prepared for PCR amplification. Birds were released after blood extraction and the entire study was approved by the Committee on the Care and Use of Laboratory Animals of the State-level Animal Experimental Teaching Demonstration Center of Sichuan Agricultural University [43].…”

Section: Sampling and Genomic Dna Extractionmentioning

confidence: 99%

Genotype frequency distributions of 28 SNP markers in two commercial lines and five Chinese native chicken populations

Zhang

Ren

et al. 2020

BMC Genet

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Background: Modern breeding in the poultry industry mainly aims to produce high-performance poultry lines and breeds in two main directions of productivity, meat and eggs. To understand more about the productive potential of lowly selected Chinese native chicken populations, we selected 14 representative SNP markers strongly associated with growth traits or carcass traits and 14 SNP markers strongly associated with egg laying traits through previous reports. By using the MassArray technology, we detected the genotype frequency distributions of these 28 SNP markers in seven populations including four lowly selected as well as one moderately selected Sichuan native chicken populations, one commercial broiler line and one commercial layer line. Results: Based on the genotype frequency distributions of these 28 SNP markers in 5 native chicken populations and 2 commercial lines, the results suggested that these Chinese indigenous chicken populations have a relatively close relationship with the commercial broiler line but a marked distinction from the commercial layer line. Two native chicken breeds, Shimian Caoke Chicken and Daheng Broilers, share similar genetic structure with the broiler line. Conclusions: Our observations may help us to better select and breed superior domestic chickens and provide new clues for further study of breeding programs in local chicken populations.

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Molecular characterization of a novel ovodefensin gene in chickens

Cited by 20 publications

References 41 publications

Population genomics identifies patterns of genetic diversity and selection in chicken

Population genomics identifies patterns of genetic diversity and selection in chicken

Transcriptome analyses to reveal the dynamic change mechanism of pigeon magnum during one egg‐laying cycle

Genotype frequency distributions of 28 SNP markers in two commercial lines and five Chinese native chicken populations

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