Molecular Biology of the Cell

Alberts, Bruce; Johnson, Alexander D.; Lewis, Julian; Morgan, David; Raff, Martin; Roberts, Keith; Wipf, Peter

doi:10.1201/9781315735368

Cited by 819 publications

(1,147 citation statements)

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“…Both enzymes associate with mitochondria, suggesting possible energy channeling resulting in a direct supply of ATP from mitochondria to glycolytic enzymes 90– 92 . HK catalyses the phosphorylation of glucose to glucose 6-phosphate and uses one ATP molecule 93 ( Figure 3). The HKI isoform is the most highly expressed of the four HKs, and is mainly found in brain, kidney, and red blood cells.…”

Section: Mitochondria In the Secret Service Of Glycolysismentioning

confidence: 99%

The advantage of channeling nucleotides for very processive functions

et al. 2017

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Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine triphosphatases) in an energetically healthy cell without becoming limiting for function. However, increasing evidence for the importance of local ATP and GTP pools, synthesised in close proximity to ATP- or GTP-consuming reactions, has fundamentally challenged our view of energy metabolism. It has become evident that cellular energy metabolism occurs in many specialised ‘microcompartments’, where energy in the form of NTPs is transferred preferentially from NTP-generating modules directly to NTP-consuming modules. Such energy channeling occurs when diffusion through the cytosol is limited, where these modules are physically close and, in particular, if the NTP-consuming reaction has a very high turnover, i.e. is very processive. Here, we summarise the evidence for these conclusions and describe new insights into the physiological importance and molecular mechanisms of energy channeling gained from recent studies. In particular, we describe the role of glycolytic enzymes for axonal vesicle transport and nucleoside diphosphate kinases for the functions of dynamins and dynamin-related GTPases.

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Section: Mitochondria In the Secret Service Of Glycolysismentioning

confidence: 99%

The advantage of channeling nucleotides for very processive functions

et al. 2017

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“…A huge number of mitochondria exist in human liver cells (approx. 1000-2000), filling up 20% of the entire cell volume and cooperatively working to serve the hepatocellular ATP demand [59]. Even the otherwise similar cells may vary substantially of their mitochondrial content, together with their size and membrane potential, [60].…”

Section: Figurementioning

confidence: 99%

Connections between Warburg’s and Szentgyorgyi’s Approach about the Causes of Cancer

Gp¹,

Szász²,

Hegyi³

2016

J Neoplasm

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Numerous theories and hypotheses are published about the causes of cancer and its hallmarks. Two remarkable principles were established and debated for a long time. The first is the Warburg-effect, which based on mitochondrial dysfunction, connected to the intensive metabolic activity of the malignancy. The other is the Szentgyorgyi's effect which describes the malignancy by changing of the cellular state (α ↔ β) explained by evolutional biology and supported by definitely improved dielectric properties of the malignant tissue from their normal counterpart while these theories have stable explanations, developed many controversies. Both are partial of completely revised time-by-time, showing new insights with new evidence as additions to these old ideas. Our objective is to demonstrate connections between these theories and start new considerations in the actual debates.

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“…The combination of the bio-belt and the bio mat is a highly effective thermotherapy available to medical professionals and home consumers who want to reduce pain, stress and abdominal fat. The Bio Mat is an approved medical device by FDA [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the reduction of cancer pain using the infra-red negative ions amethyst Bio Mat in 12 subjects over 6 months

Grant¹

2016

Nurs Palliat Care

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The amethyst Bio Mat was used by 12 subjects for one hour three times per week as well as using the Detox Salt during sleep daily over 6 months period. We used two different biofeedback devices to measure pain reduction, Complete blood count (CBC) 12 hours fasting blood test including white blood cell count (WBC) and high-sensitivity C-reactive protein (HS-CRP) to measure inflammation. The Far Infrared/Negative Ions Amethyst Bio Mat reduced pain by 21% and reduced HS-CRP by 15% and reduced Stress by 52% of 12 subjects in 6 months as validated by Pre and Post Biofeedback Brain Scans as well as fasting blood test to measure the stress hormone cortisol.

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Molecular Biology of the Cell

Cited by 819 publications

References 0 publications

The advantage of channeling nucleotides for very processive functions

The advantage of channeling nucleotides for very processive functions

Connections between Warburg’s and Szentgyorgyi’s Approach about the Causes of Cancer

Evaluating the reduction of cancer pain using the infra-red negative ions amethyst Bio Mat in 12 subjects over 6 months

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