Molecular basis of thyrotropin and thyroid hormone action during implantation and early development

Colicchia, Martina; Campagnolo, Luisa; Baldini, Enke; Ulisse, Salvatore; Valensise, H.; Moretti, Costanzo

doi:10.1093/humupd/dmu028

Cited by 144 publications

(111 citation statements)

References 254 publications

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“…Therefore, TSH may be a factor influencing ovarian reserve in infertile patients. Furthermore, thyroid hormone plays an important role for implantation as well as embryo and placenta development during early pregnancy [21]. Given that subclinical hypothyroid women are at an increased risk of infertility, elevated TSH levels may have deleterious effects on ovarian function.…”

Section: Discussionmentioning

confidence: 99%

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age

Kuroda

Uchida

Saki

et al. 2014

J Assist Reprod Genet

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Purpose Thyroid dysfunction and autoimmune thyroiditis are associated with fertility in women of reproductive age. AntiMüllerian hormone (AMH), a known biomarker of ovarian function, may be affected by impaired thyroid function; however, the relationship between AMH and thyroid hormone has not been elucidated. Methods In this case-control study, to identify the impact of thyroid hormone on ovarian reserve, we recruited 67 consecutive Japanese infertile patients and 27 normal fertile women aged 30-39 years without impact factors on thyroid and ovarian functions between 2012 and 2013. We assessed patient age, BMI and AMH, prolactin, TSH and FT4 levels of all study participations as independent variables. To evaluate the relationship between AMH and thyroid hormone, we matched patients by age and body mass index as confounding factors using 1:1 matching for statistical analysis of healthy fertile women and infertile patients and obtained 23 pairs. Then, independent variables were subjected to multiple regression analysis.Results Multiple regression analysis showed that both thyroid-stimulating hormone (TSH) levels and patient age were negatively correlated with AMH levels in infertile patients (patient age and TSH: standardized partial regression coefficient (β), −0.534 and −0.361; p=0.003 and 0.036, respectively), but not in normal fertile women. Conclusions AMH levels were inversely correlated with TSH levels in infertile women of reproductive age.

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Section: Discussionmentioning

confidence: 99%

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age

Kuroda

Uchida

Saki

et al. 2014

J Assist Reprod Genet

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“…The pivotal role which thyroid function plays in several aspects of female reproduction has been well documented by several investigators [1][2][3]. Given its relevance to reproduction and pregnancy, women with infertility are routinely screened for thyroid function with serum thyroid-stimulating hormone (TSH) prior to elective fertility treatment [4].…”

Section: Introductionmentioning

confidence: 99%

Donor TSH level is associated with clinical pregnancy among oocyte donation cycles

Karmon

Cardozo

Souter

et al. 2016

J Assist Reprod Genet

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Purpose The purpose of the study is to evaluate the association between donor TSH level (independent of recipient TSH level) and recipient pregnancy outcome among fresh donor oocyte IVF cycles. Methods This is a retrospective cohort study investigating 232 consecutive fresh donor-recipient cycles (200 total oocyte donors) at an academic medical center. Main outcome measures include clinical pregnancy and live birth. Results Cycles were categorized into two groups based on donor TSH level (< 2.5 and ≥ 2.5 mIU/L). After controlling for multiple donor and recipient characteristics, the probability of clinical pregnancy was significantly lower among donors with TSH levels ≥2.5 mIU/L compared to those with TSH values <2.5 mIU/L (43.1 %, 95 % CI 28.5-58.9, versus 66.7 %, 95 % CI 58.6-73.9, respectively, p = 0.01). The difference in live birth rates between the two groups did not achieve statistical significance (43.1 %, versus 58.0 %,, respectively, p = 0.09). Conclusions Donor TSH level, independent of recipient TSH level, is associated with recipient clinical pregnancy. These findings suggest that thyroid function may impact the likelihood of pregnancy at the level of the oocyte.

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“…The present study also supports the previous findings by Cramer et al 10 Furthermore, in one study, the role of TSH in implantation and embryo development during early pregnancy has been well documented. 11 Therefore, it is clear that subclinical hypothyroid women with high TSH values are at increased risk for infertility. Clinical evidence suggests a diminished ovarian reserve in infertile patients with elevated serumTSH levels.…”

Section: Discussionmentioning

confidence: 99%

Comparisons and correlations of anti mullerian hormone and thyroid stimulating hormones in fertile and subfertile women

2020

IJCBR

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Introduction and Objectives: Thyroid dysfunction and autoimmunity are related to adverse impact on fertility in reproductive aged women. Anti-Mullerian hormone (AMH), biomarker of 'ovarian age' may be affected by impaired thyroid function, but the relationship between AMH and thyroid hormone is unclear. The aim of this study was to determine the impact of thyroid stimulating hormone (TSH) on AMH levels. Materials and Methods:In this case-control study, to identify the impact of thyroid hormone on ovarian reserve, we recruited 30 consecutive Indian infertile patients and 30 normal fertile women aged 19 -39 years without impact factors on thyroid and ovarian functions between April 2017 and September 2017. We assessed patient age, AMH, and TSH levels of all study participants as independent variables. We also evaluated the correlations between AMH and TSH in our study groups. In addition, independent variables were subjected to multiple regression analysis. Results: Our results showed significant changes in AMH and TSH between groups. The increased TSH status in the subfertile cases was inversely correlated with the TSH levels (r=-0.44, p<0.05). The TSH levels were independently associated with the decreased AMH levels in infertile patients (β= -0.82 p = < 0.0001). Conclusion: AMH levels were inversely correlated with TSH levels in infertile women of reproductive age. Further studies with large sample size are warranted in future.

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Molecular basis of thyrotropin and thyroid hormone action during implantation and early development

Cited by 144 publications

References 254 publications

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age

Donor TSH level is associated with clinical pregnancy among oocyte donation cycles

Comparisons and correlations of anti mullerian hormone and thyroid stimulating hormones in fertile and subfertile women

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