Molecular Angiogenic Signaling in Angiofibromas After Embolization

Hypoxia-Inducible Factor-1α (HIF-1α) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis

“…However, visual assessment showed that in the ischemic areas of embolized tissues, the viable cells maintained high levels of HIF-1α expression and did not appear to differ from JNA tissue without embolization (not shown in the results). This result is consistent with that reported by Ngan et al 16 The present study is the first to show significant positive correlations between HIF-1α and CREG, OPN, and c-Src expression in JNA. Our results indicated that CREG, OPN, and c-Src may be upstream molecules regulating the level of HIF-1α in JNA as well as in other tissues, and there may be synergistic effects among these molecules ( Figure 5).…”

“…However, visual assessment showed that in the ischemic areas of embolized tissues, the viable cells maintained high levels of HIF-1α expression and did not appear to differ from JNA tissue without embolization (not shown in the results). This result is consistent with that reported by Ngan et al 16…”

Correction: Antiproliferative Effects of Fluoxetine on Colon Cancer Cells and in a Colonic Carcinogen Mouse Model

“…Our previous report already showed that FLX reduced colonic microvessel density by decreasing VEGF expression in preneoplastic lesions [5], and that high stromal proliferation increased the number of CD133positive cells [17]. An intriguing possibility was indicated by the discovery of a small subset of stromal spindle cells expressing CD133 and CD34 in angiofibromas [39]. These authors suggested an acquired potential of stromal cells to transit toward an endothelial phenotype [39].…”

Antiproliferative Effects of Fluoxetine on Colon Cancer Cells and in a Colonic Carcinogen Mouse Model

“…Our previous report already showed that FLX reduced colonic microvessel density by decreasing VEGF expression in preneoplastic lesions [5], and that high stromal proliferation increased the number of CD133-positive cells [17]. An intriguing possibility was indicated by the discovery of a small subset of stromal spindle cells expressing CD133 and CD34 in angiofibromas [39]. These authors suggested an acquired potential of stromal cells to transit toward an endothelial phenotype [39].…”

“…An intriguing possibility was indicated by the discovery of a small subset of stromal spindle cells expressing CD133 and CD34 in angiofibromas [39]. These authors suggested an acquired potential of stromal cells to transit toward an endothelial phenotype [39]. Further reports reinforced this hypothesis, since endothelial progenitor cells lose the expression of CD133 during their differentiation process into vascular cells, while the expression of CD34 is increased [30], [40]–[41].…”