Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration

Favier, Anne-Laure; Nikovics, Krisztina

doi:10.3390/biomedicines11051416

Cited by 2 publications

(2 citation statements)

References 28 publications

(28 reference statements)

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“…These cells express a range of proteins that inhibit/block axonal regrowth such as vimentin (Vim), GFAP, and ECM proteins, including chondroitin sulfate proteoglycans (CSPGs) [11,106,[108][109][110][111]. Furthermore, following injury, nerve and glial cells die as a result of activation of microglial cells and infiltration of macrophages and lymphocyte cells [112]. It is obvious that the inhibition of GFAP expression in progenitor cells of the SC and, on the other hand, the stimulation of their neuronal differentiation and viability are the key issues of research.…”

Section: Sc Regeneration: General Coursementioning

confidence: 99%

Tail and Spinal Cord Regeneration in Urodelean Amphibians

Grigoryan,

Markitantova

2024

Life

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Urodelean amphibians can regenerate the tail and the spinal cord (SC) and maintain this ability throughout their life. This clearly distinguishes these animals from mammals. The phenomenon of tail and SC regeneration is based on the capability of cells involved in regeneration to dedifferentiate, enter the cell cycle, and change their (or return to the pre-existing) phenotype during de novo organ formation. The second critical aspect of the successful tail and SC regeneration is the mutual molecular regulation by tissues, of which the SC and the apical wound epidermis are the leaders. Molecular regulatory systems include signaling pathways components, inflammatory factors, ECM molecules, ROS, hormones, neurotransmitters, HSPs, transcriptional and epigenetic factors, etc. The control, carried out by regulatory networks on the feedback principle, recruits the mechanisms used in embryogenesis and accompanies all stages of organ regeneration, from the moment of damage to the completion of morphogenesis and patterning of all its structures. The late regeneration stages and the effects of external factors on them have been poorly studied. A new model for addressing this issue is herein proposed. The data summarized in the review contribute to understanding a wide range of fundamentally important issues in the regenerative biology of tissues and organs in vertebrates including humans.

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Section: Sc Regeneration: General Coursementioning

confidence: 99%

Tail and Spinal Cord Regeneration in Urodelean Amphibians

Grigoryan,

Markitantova

2024

Life

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“…The alleged role of the immune system in ECM remodeling is mentioned above. However, the immune system is also, and above all, the first line of defense and a participant in the reparative processes in both epimorphic regeneration and scarring [163][164][165]. The responses of the immune system primarily depend on its own characteristics that are species-and age-specific for animals, as well as on the characteristics of the injury inflicted.…”

Section: Role Of Immune System In Nr Regeneration In Amphibiansmentioning

confidence: 99%

Cellular and Molecular Triggers of Retinal Regeneration in Amphibians

Markitantova,

Grigoryan

2023

Life

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Understanding the mechanisms triggering the initiation of retinal regeneration in amphibians may advance the quest for prevention and treatment options for degenerating human retina diseases. Natural retinal regeneration in amphibians requires two cell sources, namely retinal pigment epithelium (RPE) and ciliary marginal zone. The disruption of RPE interaction with photoreceptors through surgery or injury triggers local and systemic responses for retinal protection. In mammals, disease-induced damage to the retina results in the shutdown of the function, cellular or oxidative stress, pronounced immune response, cell death and retinal degeneration. In contrast to retinal pathology in mammals, regenerative responses in amphibians have taxon-specific features ensuring efficient regeneration. These include rapid hemostasis, the recruitment of cells and factors of endogenous defense systems, activities of the immature immune system, high cell viability, and the efficiency of the extracellular matrix, cytoskeleton, and cell surface remodeling. These reactions are controlled by specific signaling pathways, transcription factors, and the epigenome, which are insufficiently studied. This review provides a summary of the mechanisms initiating retinal regeneration in amphibians and reveals its features collectively directed at recruiting universal responses to trauma to activate the cell sources of retinal regeneration. This study of the integrated molecular network of these processes is a prospect for future research in demand biomedicine.

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Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration

Abstract: Over the past 70 years, significant progress has been made in understanding the molecular and cellular mechanisms of inflammation and tissue regeneration [...]

Cited by 2 publications

References 28 publications

Tail and Spinal Cord Regeneration in Urodelean Amphibians

Tail and Spinal Cord Regeneration in Urodelean Amphibians

Cellular and Molecular Triggers of Retinal Regeneration in Amphibians

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