Molecular and cellular effects of Auger emitters: 2008–2011

Yasui, Linda S.

doi:10.3109/09553002.2012.702296

Cited by 13 publications

(7 citation statements)

References 37 publications

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“…This strongly suggested that it was radiosensitization by Pt that caused the decrease in cell survival rather than the intrinsic cytotoxicity of the sensitizer used in combination with LEX. Although most of the enhancement in radiosensitization from the 160-kV source occurs from X-rays below the K-edge, it follows that the corresponding cell survival due to Pt Auger decays in proximity to cell nuclei versus cytoplasm [ 37 ] was higher with 6-MV photons.…”

Section: Discussionmentioning

confidence: 99%

Tumoricidal activity of low-energy 160-KV versus 6-MV X-rays against platinum-sensitized F98 glioma cells

Lim

Pradhan

Barth

et al. 2014

Journal of Radiation Research

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The purposes of this study were (i) to investigate the differences in effects between 160-kV low-energy and 6-MV high-energy X-rays, both by computational analysis and in vitro studies; (ii) to determine the effects of each on platinum-sensitized F98 rat glioma and murine B16 melanoma cells; and (iii) to describe the in vitro cytotoxicity and in vivo toxicity of a Pt(II) terpyridine platinum (Typ-Pt) complex. Simulations were performed using the Monte Carlo code Geant4 to determine enhancement in absorption of low- versus high-energy X-rays by Pt and to determine dose enhancement factors (DEFs) for a Pt-sensitized tumor phantom. In vitro studies were carried out using Typ-Pt and again with carboplatin due to the unexpected in vivo toxicity of Typ-Pt. Cell survival was determined using clonogenic assays. In agreement with computations and simulations, in vitro data showed up to one log unit reduction in surviving fractions (SFs) of cells treated with 1–4 µg/ml of Typ-Pt and irradiated with 160-kV versus 6-MV X-rays. DEFs showed radiosensitization in the 50–200 keV range, which fell to approximate unity at higher energies, suggesting marginal interactions at MeV energies. Cells sensitized with 1–5 or 7 µg/ml of carboplatin and then irradiated also showed a significant decrease (P < 0.05) in SFs. However, it was unlikely this was due to increased interactions. Theoretical and in vitro studies presented here demonstrated that the tumoricidal activity of low-energy X-rays was greater than that of high-energy X-rays against Pt-sensitized tumor cells. Determining whether radiosensitization is a function of increased interactions will require additional studies.

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Section: Discussionmentioning

confidence: 99%

Tumoricidal activity of low-energy 160-KV versus 6-MV X-rays against platinum-sensitized F98 glioma cells

Lim

Pradhan

Barth

et al. 2014

Journal of Radiation Research

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“…Typically, the dose-limiting organ in targeted radionuclide therapy (TRT) is the bone marrow (Sgouros, 2007;Sgouros et al, 2000). Auger-electron emitters are attractive candidate radionuclides in TRT of disseminated diseases (and micrometastasis) due to a vanishing cross-irradiation effect which spares healthy cells in the vicinity of the targeted cells (Fischer et al, 2008;Kassis, 2011Kassis, , 2004Yasui, 2012). It has been reported (Behr et al, 2000;Boswell and Brechbiel, 2005) that Auger emitters (I-125, In-111) may exhibit better therapeutic effect, when bound to an internalizing monoclonal antibody, than β À -emitters (I-131, Y-90) which have been used successfully in the treatment of non-Hodgkins' lymphoma Pouget et al, 2011;Song and Sgouros, 2011).…”

Section: Introductionmentioning

confidence: 99%

Calculation of cellular S-values using Geant4-DNA: The effect of cell geometry

Šefl

Incerti

Papamichael

et al. 2015

Applied Radiation and Isotopes

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“…Auger electrons have a very low energy (from a few eV to few keV) and those with energy below 1 keV are considered as high LET particles (from 4 to 26 keV/µm). Their path length in biological matter is very short, between about 2 nm and 500 nm ( [20] and for reviews see [3,4,6,11,12,19,32]), and they produce highly localized energy deposits. They have been mostly used for targeting the nucleus [1,13,14].…”

Section: Introductionmentioning

confidence: 99%