Mola hidatiforme e doença trofoblástica gestacional

Andrade, Jurandyr Moreira de

doi:10.1590/s0100-72032009000200008

Cited by 10 publications

(19 citation statements)

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“…13 A manutenção da gestação em casos de GGMC tem sido descrita por diversos autores, apesar das altas taxas de resultados obstétricos desfavoráveis. 4,5,7,8,10,14,15 Na conduta conservadora, recomenda-se seguimento clínico rigoroso, evoluíram para pré-eclâmpsia grave; 23 (43,4%) evoluíram com aborto espontâneo antes de 24 semanas de gestaç ão; e 28 (52,8%) evoluíram com gestaç ões de 28 semanas ou mais, o que resultou em 20 nascidos vivos (37,7%). Yela et al, 10 em uma revisão de 29 trabalhos, encontraram 159 casos de GGMC; desses, apenas 56 (35%) apresentaram término da gestação com feto vivo.…”

Section: Discussionunclassified

Gestação gemelar com mola hidatiforme completa e feto vivo

Soares

Rizzo

Deus

et al. 2014

Reprodução & Climatério

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“…3,5 Ultrasound features CHM usually presents as a central heterogeneous mass with various anechoic spaces (hydatidiform swelling of the hydroptic chorionic villi) classically called "bunch of grapes" or "snowstorm" pattern associated with ovarian theca lutein cysts, but with no embryo, fetus or amniotic fluid (there are rare cases described in the literature with fetus). 10,11 PHM presents as focal anechoic spaces and increased echogenicity of the chorionic villi, classically named the "Swiss cheese pattern", usually with a fetus and amniotic fluid but rarely presenting theca lutein cysts.…”

Section: Laboratorial Findingsmentioning

confidence: 99%

“…They are usually diploid and androgenetic, 80% resulting from duplication of the genome of a single sperm and 20% from dispermic fertilization of an ovum, mainly 46 XX but it can be 46 XY. 3,10,14 PHM show villous hydroptic changes with abnormal focal irregular villi and trophoblastic hyperplasia with pseudo inclusions. They're almost always triploid as a result of the fertilization of an ovum by 2 sperms or by a diploid sperm.…”

Section: Histologic Featuresmentioning

confidence: 99%

“…Molar pregnancies are treated with suction curettage (regular curettage should be avoided due to the risk of uterine perforation). 3 If childbearing has been completed, hysterectomy is an option. 7 The adnexa do not need any intervention even in the presence of theca luthein cysts.…”

Section: Managementmentioning

confidence: 99%

“…22 Prophylaxis with anti-D globulin must be performed in Rh-negative women. 3 In cases with metastatic persistent disease to the lungs or liver after chemotherapy, surgical resection of the nodules may be an option. Radiotherapy and higher doses of Methrotrexate may be indicated if there are brain metastases.…”

Section: Managementmentioning

confidence: 99%

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Distinct gestational trophoblastic neoplasia - different entities, specific management

Brandão¹,

Silva-Rocha²,

Pinto³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Gestational trophoblastic diseases are abnormalities of the trophoblastic tissue development. They have Β-hCG as tumour marker, similar clinical manifestations but different pathological features, management and prognosis. Gestational trophoblastic neoplasia includes all forms of gestational trophoblastic disease that are invasive and/or metastasize and correspond to 10% of this group of diseases. The authors performed a retrospective review of all patients referred to our department between 1st January 2011 and 30th June 2016. Presenting symptoms, Β-hCG levels, obstetric and personal history and microscopic features were reviewed. 4 cases were identified - 2 invasive complete and 1 partial hydatidiform moles and 1 placental site trophoblastic tumour. Management and follow-up were individualized. Neither persistence nor recurrences were diagnosed after primary treatment. These case series highlights the importance of an accurate diagnosis and a long-term follow-up considering the risk of persistency or malignancy, as gestational trophoblastic neoplasia usually have good response to the adequate therapy.

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Mola hidatiforme e doença trofoblástica gestacional

Cited by 10 publications

References 0 publications

Gestação gemelar com mola hidatiforme completa e feto vivo

Distinct gestational trophoblastic neoplasia - different entities, specific management

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