MOF as nanoscale drug delivery devices: Synthesis and recent progress in biomedical applications

Moharramnejad, Mojtaba; Ehsani, Ali; Shahi, Mehrnaz; Gharanli, Sajjad; Saremi, Hossein; Malekshah, Rahime Eshaghi; Basmenj, Zahra Salmanivand; salmani, Saba; Mohammadi, Mohammad Reza

doi:10.1016/j.jddst.2023.104285

Cited by 53 publications

(32 citation statements)

References 200 publications

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“…Compared with inorganic nanomaterials, such as nano-gold, nano-silicon, and nano-carbon, polymer materials have better biosafety, which indicates their greater application potential in drug delivery and clinical practice [ 38 , 40 , 66 ]. PLGA is recognized as one of the most biodegradable polymer materials currently synthesized, with good controllability, biodegradability, and biocompatibility [ 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the emergence of functional nanomaterials has provided new ideas for improving the detection sensitivity and specificity of imaging agents [ 38 – 40 ]. Nanoimaging agents can utilize enhanced permeability and retention effects (EPR) to promote the accumulation of imaging agents, reduce nonspecific distribution, and improve imaging specificity [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

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A TMVP1-modified near-infrared nanoprobe: molecular imaging for tumor metastasis in sentinel lymph node and targeted enhanced photothermal therapy

et al. 2023

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Background TMVP1 is a novel tumor targeting polypeptide screened by our laboratory with a core sequence of five amino acids LARGR. It specially binds to vascular endothelial growth factor receptor-3 (VEGFR-3), which is mainly expressed on neo-lymphatic vessels in sentinel lymph node (SLN) with tumor metastasis in adults. Here, we prepared a targeted nanoprobe using TMVP1-modified nanomaterials for tumor metastasis SLN imaging. Results In this study, TMVP1-modified polymer nanomaterials were loaded with the near-infrared (NIR) fluorescent dye, indocyanine green (ICG), to prepare a molecular imaging TMVP1-ICG nanoparticles (NPs) to identify tumor metastasis in SLN at molecular level. TMVP1-ICG-NPs were successfully prepared using the nano-precipitation method. The particle diameter, morphology, drug encapsulation efficiency, UV absorption spectrum, cytotoxicity, safety, and pharmacokinetic properties were determined. The TMVP1-ICG-NPs had a diameter of approximately 130 nm and an ICG loading rate of 70%. In vitro cell experiments and in vivo mouse experiments confirmed that TMVP1-ICG-NPs have good targeting ability to tumors in situ and to SLN with tumor metastasis by binding to VEGFR-3. Effective photothermal therapy (PTT) with TMVP1-ICG-NPs was confirmed in vitro and in vivo. As expected, TMVP1-ICG-NPs improved ICG blood stability, targeted tumor metastasis to SLN, and enhanced PTT/photodynamic (PDT) therapy, without obvious cytotoxicity, making it a promising theranostic nanomedicine. Conclusion TMVP1-ICG-NPs identified SLN with tumor metastasis and were used to perform imaging-guided PTT, which makes it a promising strategy for providing real-time NIR fluorescence imaging and intraoperative PTT for patients with SLN metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A TMVP1-modified near-infrared nanoprobe: molecular imaging for tumor metastasis in sentinel lymph node and targeted enhanced photothermal therapy

et al. 2023

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“…[19] Importantly, the vibration at 2,562 cm À 1 in the solid-state Raman spectrum of MIL-53(Al)-(SH) 2 in Figure S28 indicates the presence of free thiol groups. [20] Preliminary thiol-disulfide exchange reactions with MIL-53(Al)-SH 2 We hypothesized that the free thiols within MIL-53(Al)-(SH) 2 would be converted to disulfide bonds following a thioldisulfide exchange reaction. As thiol-disulfide exchange is a reversible process, an activated disulfide reagent must be implemented to drive the reaction toward the formation of the mixed disulfide product.…”

Section: Synthesis and Characterization Of Mil-53(al)-shmentioning

confidence: 99%

Disulfide‐Driven Pore Functionalization of Metal–Organic Frameworks

Moore

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Feldblyum

et al. 2023

Chemistry A European J

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Post‐synthetic modification (PSM) imparts additional functionality to metal‐organic frameworks (MOFs) that is often difficult to access using solvothermal synthesis. As such, expanding the repertory of PSM reactions available to the practitioner is of increased importance for the generation of materials tailored for desired applications. Herein, we describe a method for the protecting group‐free installation of diverse functional groups within the pores of a MIL‐53(Al) analogue via disulfide bond formation. The majority of the reactions proceed with thiol‐to‐disulfide conversions ranging from high to nearly quantitative. The disulfide bonds are stable in various solvents and can be cleaved in the presence of a reducing agent.

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“…MOFs can be introduced as ideal candidates for heterogeneous catalysis for reactions due to (i) physicochemical properties, (ii) the hybrid inorganic/organic structures, (iii) the existence of uncoordinated metal sites and accessible organic sections, (iv) the suitable design of drug delivery systems, and (v) porous systems. MOFs have been introduced successfully as catalysts due to the chemical and structural diversity that can be revealed as effective differences for reactions compared to other traditional catalysts. − MOFs are a family of high nanoporous crystalline materials that are used as heterogeneous chemical catalysis to coordinate polymerization reactions. MOFs can consist of inorganic nodes (metal ions or clusters) and multitopic organic molecules (linkers) via self-assembly to make porous materials .…”

Section: Introductionmentioning

confidence: 99%

MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

et al. 2023

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Catalysts played a crucial role in advancing modern human civilization, from ancient times to the industrial revolution. Due to high cost and limited availability of traditional catalysts, there is a need to develop cost-effective, high-activity, and nonprecious metal-based electrocatalysts. Metal−organic frameworks (MOFs) have emerged as an ideal candidate for heterogeneous catalysis due to their physicochemical properties, hybrid inorganic/organic structures, uncoordinated metal sites, and accessible organic sections. MOFs are high nanoporous crystalline materials that can be used as catalysts to facilitate polymerization reactions. Their chemical and structural diversity make them effective for various reactions compared to traditional catalysts. MOFs have been applied in gas storage and separation, ion-exchange, drug delivery, luminescence, sensing, nanofilters, water purification, and catalysis. The review focuses on MOF-enabled heterogeneous catalysis for value-added compound production, including alcohol oxidation, olefin oligomerization, and polymerization reactions. MOFs offer tunable porosity, high spatial density, and single-crystal XRD control over catalyst properties. In this review, MOFs were focused on reactions of CO 2 fixation, CO 2 reduction, and photoelectrochemical water splitting. Overall, MOFs have great potential as versatile catalysts for diverse applications in the future.

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MOF as nanoscale drug delivery devices: Synthesis and recent progress in biomedical applications

Cited by 53 publications

References 200 publications

A TMVP1-modified near-infrared nanoprobe: molecular imaging for tumor metastasis in sentinel lymph node and targeted enhanced photothermal therapy

A TMVP1-modified near-infrared nanoprobe: molecular imaging for tumor metastasis in sentinel lymph node and targeted enhanced photothermal therapy

Disulfide‐Driven Pore Functionalization of Metal–Organic Frameworks

MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

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