Modulatory effects of selenium and zinc on the immune system

Ferencík, M; Ebringer, L.

doi:10.1007/bf02931378

Cited by 141 publications

(88 citation statements)

References 39 publications

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“…Similar to vitamin D, zinc is also very important for immune function, and deficiency in zinc has been associated with decreased resistance to viral infection. 35 Affecting a number of immune cells and functions, zinc specifically influences lymphocyte maturation, cytokine production, and generation of free radicals while maintaining normal macrophage and natural killer (NK) cell activity in the immune response 36 ; it also plays a role in T-cell and neutrophil activity as well as B-cell development. Zinc supplementation has also been found to reduce mortality from diarrhea and pneumonia 37 and has been shown to be beneficial in preventing respiratory infection.…”

Section: Vitamin D Why Vitamin D?mentioning

confidence: 99%

Micronutrients and Dengue

Ahmed

Finkelstein

Stewart

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue virus infection is the most widespread mosquito-borne viral infection in humans and has emerged as a serious global health challenge. In the absence of effective treatment and vaccine, host factors including nutritional status, which may alter disease progression, need investigation. The interplay between nutrition and other infections is well-established, and modulation of nutritional status often presents a simple low-cost method of interrupting transmission, reducing susceptibility, and/or ameliorating disease severity. This review examines the evidence on the role of micronutrients in dengue virus infection. We found critical issues and often inconsistent results across studies; this finding along with the lack of sufficient literature in this field have limited our ability to make any recommendations. However, vitamins D and E have shown promise in small supplementation trials. In summary, the role of micronutrients in dengue virus infection is an exciting research area and needs to be examined in well-designed studies with larger samples.

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Section: Vitamin D Why Vitamin D?mentioning

confidence: 99%

Micronutrients and Dengue

Ahmed

Finkelstein

Stewart

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…This is especially the case in elderly hemodialysis patients, as zinc is a catalytic, structural, and regulatory ion for enzymes, proteins, and transcription factors, and thus a key trace element in many homeostatic mechanisms of the body, including immune responses. [6,7] However, no definite cause has been shown to induce this immunodeficiency level yet.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Protection of Hemodialysis Patients Against Diphtheria and Tetanus

2009

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Patients with end stage renal disease suffer from a high incidence of infectious diseases believed to be related to their impaired immune system. To determine the antitetanus and antidiphtheria IgG antibody levels in Iranian hemodialysis patients with end stage renal disease, as well as its association with sex, age, hemoglobin, zinc serum level, serum albumin, duration of dialysis, number of dialysis per week, dialysis adequacy, erythropoietin or iron supplements such as venofer, body mass index (BMI), and underlying renal disorder, we conducted a crosssectional study on a total of 112 hemodialysis patients with end stage renal disorder (60 male, 52 female ) and 36 healthy individuals in the control group (14 male, 22 female). The patients and the control group received no antitetanus or antidiphtheria vaccine or immunoglobulin in the year prior to the investigation. The serum antitetanus and antidiphtheria IgG antibody levels were measured using the ELISA method. We found out that only 16% of our hemodialysis patients were immune to diphtheria (19% of the control group), and this rate for tetanus was 24% (48.2% in the healthy control). Except for the hemodialysis duration, none of the mentioned factors seemed to affect immunity. We conclude that in our study, the level of the antitetanus IgG antibody (unlike the antidiphtheria IgG antibody level) is significantly different among the hemodialysis patients, the chronic hemodialysis patients, and the control group.

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“…Furthermore, a high selenium intake has been proposed to reduce the risk of diseases induced by oxidative stress and inflammation (Ferencik and Ebringer, 2003) and has been related to changes in lipid metabolism (Bleys et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

et al. 2008

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Objectives: To evaluate the associations between serum complement factor 3 (C3) and several anthropometrical, biochemical and lifestyle features in healthy young adults, emphasizing on the putative effect of selenium intake on C3 concentrations. Methods: This study enrolled 100 healthy young adults aged 18-34 years. Anthropometric and blood pressure measurements and lifestyle features were analyzed. Fasting blood samples were collected for the measurement of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerols and C3 concentrations. Nail samples were collected for the analysis of selenium concentrations. Results: Values of BMI (P ¼ 0.034), sum of skinfold thicknesses (STs) (P ¼ 0.021), body fat mass (BFM) (P ¼ 0.023), percentage of overweight subjects (P ¼ 0.007), serum triacylglycerols (P ¼ 0.012) and nail selenium (P ¼ 0.001) were significantly different between subjects above and below the median of serum C3 concentrations. The following correlations with serum C3 were identified tricipital ST (P ¼ 0.033), sum of STs (P ¼ 0.012), BMI (P ¼ 0.008), BFM (P ¼ 0.018), waist-to-height ratio (P ¼ 0.016), serum glucose (P ¼ 0.045), serum triacylglycerols (P ¼ 0.001) and nail selenium (P ¼ 0.006). Circulating C3 showed a positive association with several adiposity markers such as BMI (P ¼ 0.001), waist circumference (P ¼ 0.006), waist-to-height ratio (P ¼ 0.002), BFM (P ¼ 0.025), as well as serum glucose (P ¼ 0.027) and triacylglycerols (Po0.001), whereas nail selenium was a statistically significant negative predictor of C3 concentrations (P ¼ 0.018). Conclusions: C3 seems to be related with selenium status and several anthropometrical and biochemical measurements linked to metabolic syndrome in apparently healthy young adults. These findings suggest a possible role for selenium intake in the modulation of C3, whose assessment may be an early marker of metabolic syndrome manifestations.

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Modulatory effects of selenium and zinc on the immune system

Cited by 141 publications

References 39 publications

Micronutrients and Dengue

Micronutrients and Dengue

A Study on the Protection of Hemodialysis Patients Against Diphtheria and Tetanus

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

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