Modulation of T-Cell Functions in Aging

Doria, Gino; Mancini, Camillo; Frasca, Daniela

doi:10.1007/978-1-4613-0513-2_36

Cited by 2 publications

(2 citation statements)

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“…The physiological significance of this polymorphism is uncertain because of its location in an untranslated region. Another SNP at nucleotide position +573 was investigated in hypertension and diabetes (Doria et al 1997;Chaves et al 2001). Erdmann et al (1999) characterized nine other SNPs, which may have the potential to influence AT 1 R gene expression given their location in the functional promoter region of the gene.…”

Section: At 1 R Gene Polymorphism In Hypertension and Related Diseasesmentioning

confidence: 99%

“…Moreover, no association was shown between AT 1 R gene polymorphisms and stroke (Tiret et al 1998); on the contrary, the presence of the C allele in the AT 1 R gene might be associated with faster deterioration of renal function (Buraczynska et al 2002;Coll et al 2003). Originally a synergistic effect was suggested for AT 1 R +1166A/C polymorphism and poor glycaemic control on the risk of diabetic nephropathy in insulin-dependent diabetic patients (Doria et al 1997); but this association was not confirmed in subsequent studies (Chowdhury et al 1997;Savage et al 1999;Tarnow et al 2000). RAS gene polymorphism was also investigated in obesity, and particularly in obesityassociated hypertension.…”

Section: At 1 R Gene Polymorphism In Hypertension and Related Diseasesmentioning

confidence: 99%

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Polymorphism in angiotensin II receptor genes and hypertension

Baudin

2005

Experimental Physiology

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Molecular variants of individual components of the renin–angiotensin system (RAS) have been thought to contribute to an inherited predisposition towards essential hypertension. The angiotensin II type 1 receptor (AT‐1) mediates the major pressor and trophic actions of angiotensin II (Ang II) and at least 50 different polymorphisms have been described in the AT‐1 gene (AT1R gene); in particular, the C allele of the +1166A/C polymorphism has been associated with the severe form of essential hypertension, but the role of this polymorphism is still ambiguous in pathologies related to high Ang II levels, such as deterioration of renal function, arterial stiffness and hypertrophic cardiomyopathy. A relationship was suggested between AT1R A1166C polymorphism and the humoral and renal haemodynamic responses to losartan, an AT‐1 blocker, as well as with enhanced Ang II vascular reactivity or sensitivity. Polymorphism has also been described in angiotensin II type 2 receptor (AT‐2) gene, AT‐2 being the mediator for vasodilatation, natriuresis and apoptosis of smooth muscle cells; associations were found between some of these polymorphisms and both hypertension and left ventricular structure. Further evaluation in adequately powered studies is necessary for full assessment of the allelic markers in genes for RAS components, as well as to allow determination of a predisposition to hypertension or related diseases and selection of an appropriate antihypertensive drug for an individual.

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Section: At 1 R Gene Polymorphism In Hypertension and Related Diseasesmentioning

confidence: 99%