Modulation of T and B cell subpopulations during high dose intravenous immunoglobulin therapy

The Use and Mechanisms of Action of Intravenous Immunoglobulin: An Update

“…Immune modulation occurs rapidly first demonstrated during the infusion of IgG in ITP by day 3 (Macey & Newland, 1988). This is paralleled in vitro by a reduction in immunoglobulin production (Dammacco et al, 1986).…”

“…In general this was transient and requiring larger than normal doses. In the acute, uncontrolled state this may be useful in allowing a safer splenectomy or providing time for more conventional therapies to work (Newland et al, 1988). There have also been occasional reports that IVIgG may improve the outcome of pregnancy in severe Rhesus immunization (Camara et al, 1988).…”

“…Acquired disorders of clotting. The autoantibody in acquired haernophilia may be reduced following IVIgG either as idiotype/anti-idiotype neutralization in the plasma (Sultan et al, 1984) or as a direct cellular effect (Newland et al, 1988). Unfortunately the response is usually of little clinical benefit when used alone and often needs to be combined with immunosuppressive therapy.…”

The Use and Mechanisms of Action of Intravenous Immunoglobulin: An Update

“…Immune modulation occurs rapidly first demonstrated during the infusion of IgG in ITP by day 3 (Macey & Newland, 1988). This is paralleled in vitro by a reduction in immunoglobulin production (Dammacco et al, 1986).…”

“…In general this was transient and requiring larger than normal doses. In the acute, uncontrolled state this may be useful in allowing a safer splenectomy or providing time for more conventional therapies to work (Newland et al, 1988). There have also been occasional reports that IVIgG may improve the outcome of pregnancy in severe Rhesus immunization (Camara et al, 1988).…”

“…Acquired disorders of clotting. The autoantibody in acquired haernophilia may be reduced following IVIgG either as idiotype/anti-idiotype neutralization in the plasma (Sultan et al, 1984) or as a direct cellular effect (Newland et al, 1988). Unfortunately the response is usually of little clinical benefit when used alone and often needs to be combined with immunosuppressive therapy.…”

The Therapeutic Value of HPA‐1a‐Negative Platelet Transfusion in Post‐Transfusion Purpura Complicated by Life‐Threatening Haemorrhage

“…The immediate beneficial effect of IVIG infusion in acute ITP has been attributed to a transient blockade of Fc receptor function of mononuclear phagocytic system, resulting in reduced clearance of antibody-coated platelets [I I]. It has been postulated that the more longterm effect is due to reduction in platelets antibody production [12]. I n PTP, the majority of cases respond rapidly to IVIG [13].…”

The Therapeutic Value of HPA-1a-Negative Platelet Transfusion in Post-Transfusion Purpura Complicated by Life-Threatening Haemorrhage

“…It has been postulated that the more long term effect is due to reduction in platelets antibody production [12]. In PTP, the majority of cases respond rapidly to IVIG [13].…”

The Use and Mechanisms of Action of Intravenous Immunoglobulin: An Update

“…Immune modulation occurs rapidly first demonstrated during the infusion of IgG in ITP by day 3 (Macey & Newland, 1988). This is paralleled in vitro by a reduction in immunoglobulin production (Dammacco et al, 1986).…”

“…In general this was transient and requiring larger than normal doses. In the acute, uncontrolled state this may be useful in allowing a safer splenectomy or providing time for more conventional therapies to work (Newland et al, 1988). There have also been occasional reports that IVIgG may improve the outcome of pregnancy in severe Rhesus immunization (Camara et al, 1988).…”

“…Acquired disorders of clotting. The autoantibody in acquired haernophilia may be reduced following IVIgG either as idiotype/anti-idiotype neutralization in the plasma (Sultan et al, 1984) or as a direct cellular effect (Newland et al, 1988). Unfortunately the response is usually of little clinical benefit when used alone and often needs to be combined with immunosuppressive therapy.…”

The Therapeutic Value of HPA‐1a‐Negative Platelet Transfusion in Post‐Transfusion Purpura Complicated by Life‐Threatening Haemorrhage

“…The immediate beneficial effect of IVIG infusion in acute ITP has been attributed to a transient blockade of Fc receptor function of mononuclear phagocytic system, resulting in reduced clearance of antibody-coated platelets [I I]. It has been postulated that the more longterm effect is due to reduction in platelets antibody production [12]. I n PTP, the majority of cases respond rapidly to IVIG [13].…”

The Therapeutic Value of HPA-1a-Negative Platelet Transfusion in Post-Transfusion Purpura Complicated by Life-Threatening Haemorrhage

“…It has been postulated that the more long term effect is due to reduction in platelets antibody production [12]. In PTP, the majority of cases respond rapidly to IVIG [13].…”

The Use and Mechanisms of Action of Intravenous Immunoglobulin: An Update

“…Immune modulation occurs rapidly first demonstrated during the infusion of IgG in ITP by day 3 (Macey & Newland, 1988). This is paralleled in vitro by a reduction in immunoglobulin production (Dammacco et al, 1986).…”

“…In general this was transient and requiring larger than normal doses. In the acute, uncontrolled state this may be useful in allowing a safer splenectomy or providing time for more conventional therapies to work (Newland et al, 1988). There have also been occasional reports that IVIgG may improve the outcome of pregnancy in severe Rhesus immunization (Camara et al, 1988).…”

“…Acquired disorders of clotting. The autoantibody in acquired haernophilia may be reduced following IVIgG either as idiotype/anti-idiotype neutralization in the plasma (Sultan et al, 1984) or as a direct cellular effect (Newland et al, 1988). Unfortunately the response is usually of little clinical benefit when used alone and often needs to be combined with immunosuppressive therapy.…”

The Therapeutic Value of HPA‐1a‐Negative Platelet Transfusion in Post‐Transfusion Purpura Complicated by Life‐Threatening Haemorrhage

“…The immediate beneficial effect of IVIG infusion in acute ITP has been attributed to a transient blockade of Fc receptor function of mononuclear phagocytic system, resulting in reduced clearance of antibody-coated platelets [I I]. It has been postulated that the more longterm effect is due to reduction in platelets antibody production [12]. I n PTP, the majority of cases respond rapidly to IVIG [13].…”

The Therapeutic Value of HPA-1a-Negative Platelet Transfusion in Post-Transfusion Purpura Complicated by Life-Threatening Haemorrhage

“…It has been postulated that the more long term effect is due to reduction in platelets antibody production [12]. In PTP, the majority of cases respond rapidly to IVIG [13].…”