Abstract:
AbstractStore-operated Ca 2+ entry plays an important role in Ca 2+ homeostasis in cells but the mechanisms of control of these channels are not completely understood. We describe an investigation of the role of the CD38-cyclic-ADP-ribose (cADPR)-ryanodine-channel (RyR) signaling pathway in store-operated Ca 2+ entry in human smooth muscle. We observed that human myometrial cells have a functional storeoperated Ca 2+ entry mechanism. Furthermore, we observed the presence of transient receptor potential 1, 3, … Show more
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