2015
DOI: 10.1111/jphp.12451
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Abstract: BZ triggers an oxidative and nitrosative route, which is associated with increased prostaglandin synthesis and marked damages to the lipids and proteins of the cardiac tissue. IB treatment attenuated reactive stresses triggered by BZ, which was an independent effects of this drug on the endogenous antioxidant enzymes. Individually, but not together, BZ and IB reduced the cardiac inflammatory status, indicating a beneficial and complex drug interaction.

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Cited by 15 publications
(12 citation statements)
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References 47 publications
(90 reference statements)
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“…Among these genes, we identified CAT (catalase), GCLC (glutamate-cysteine ligase catalytic subunit), GCLM (glutamate-cysteine ligase modifier subunit), GPX1 (glutathione peroxidase 1), GSR (glutathione reductase), GSS (glutathione synthetase) and GSTP1 (glutathione S-transferase π1) (Additional file 2: Table S2). In contrast to our findings of downregulation of these genes, recent studies have shown enzymatic upregulation of CAT, SOD and GPX as a natural response to attenuate damage mediated by ROS/RNS after 12 h of exposure to BZ [28, 30]. These differences suggest that to evaluate the significance of these results, a strategy combining different time points could elucidate the true involvement of these molecules in host cell responses to BZ treatment.…”
Section: Resultscontrasting
confidence: 99%
“…Among these genes, we identified CAT (catalase), GCLC (glutamate-cysteine ligase catalytic subunit), GCLM (glutamate-cysteine ligase modifier subunit), GPX1 (glutathione peroxidase 1), GSR (glutathione reductase), GSS (glutathione synthetase) and GSTP1 (glutathione S-transferase π1) (Additional file 2: Table S2). In contrast to our findings of downregulation of these genes, recent studies have shown enzymatic upregulation of CAT, SOD and GPX as a natural response to attenuate damage mediated by ROS/RNS after 12 h of exposure to BZ [28, 30]. These differences suggest that to evaluate the significance of these results, a strategy combining different time points could elucidate the true involvement of these molecules in host cell responses to BZ treatment.…”
Section: Resultscontrasting
confidence: 99%
“…In parallel, Santos et al (32) demonstrated that noninfected Swiss mice treated with BZ (100 mg/kg) presented increased levels of nitric oxide, malondialdehyde, and carbonyl protein. The authors also showed that the activity of antioxidant enzymes was increased, indicating an adaptive upregulation in response to oxidative damage.…”
Section: Discussionmentioning
confidence: 93%
“…The supernatant was collected for the cytokine assay. The concentration of cytokines was measured by the sandwich ELISA [ 32 ]. Adiponectin and high-molecular weight (HMW) adiponectin were measured using commercial kits, according to the manufacturer's instructions (USCN Life Science Inc., Wuhan, China).…”
Section: Methodsmentioning
confidence: 99%