Modulation of octopaminergic and cholinergic pathways induced by Caatinga tree Manilkara rufula chemical compounds in Nauphoeta cinerea cockroaches

Borges, Bruna Trindade; Vieira, Patrícia de Brum; Leal, Allan Pinto; Karnopp, Etiely; Ogata, Bárbara A.B.; Rosa, Maria Eduarda; Barreto, Yuri Correia; Oliveira, Raquel Soares; Belo, Cháriston André Dal; Vinadé, Lúcia

doi:10.1016/j.pestbp.2020.104651

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…A selective antagonist of octopaminergic receptors phentolamine decreased the HR within approximately 2 min to 72 beats · min −1 (Borges et al, 2020). These opposite effects of agonist and antagonist hardly explain the involvement of the same underlying mechanism, even when both were applied concurrently.…”

Section: Modulation Of Hrmentioning

confidence: 99%

“…Also neurotransmitters and related peptides may influence the heart performance and their repertoire is evolutionary conserved (Springer et al, 2004). In cockroach Nauphoeta cinerea the OA − octopamine at 15 μg/ 100 μl was concluded to increase the HR (Borges et al, 2020), but the difference between 103 versus 98 beats • min −1 of control is marginal. Especially, since the latter frequency is a baseline value for all three groups.…”

Section: Modulation Of Hrmentioning

confidence: 99%

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Probability that there is a mammalian counterpart of cardiac clock in insects

Kodirov

2022

Arch Insect Biochem Physiol

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Whether or not the hyperpolarization‐activated cyclic nucleotide‐gated nonselective cation channel (HCN or funny current If) is involved in pacemaking − recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. In latter group of animals prevailingly the electrical signals and function of heart in terms of chrono‐ and inotropy are elucidated. Although in simpler models including insects experimental outcomes are reproducible and robust, involvement of “cardiac clock” mechanism in pacemaking is not conclusive. In this assay, the mechanisms of heartbeat are synthesized by focused comparisons between insect and mammalian hearts.

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Section: Modulation Of Hrmentioning

confidence: 99%

Section: Modulation Of Hrmentioning

confidence: 99%

Probability that there is a mammalian counterpart of cardiac clock in insects

Kodirov

2022

Arch Insect Biochem Physiol

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Persistent oxidative injury and neurobehavioral impairment in adult male and female Nauphoeta cinerea exposed to perfluorooctanoic acid

Babalola

Mohammed

Olaseni

et al. 2023

Environmental Toxicology and Pharmacology

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Fipronil affects cockroach behavior and olfactory memory

Rosa

Campos

Borges

et al. 2023

Journal of Experimental Biology

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Fipronil (FPL), an insecticide belonging to the class of phenylpyrazoles, is associated with the widespread mortality of pollinator insects worldwide. Based on studies carried out on residual concentrations of FPL commonly found in the environment, in this work, we evaluated the sublethal effects of FPL on behavior and other neurophysiological parameters using the cockroach Nauphoeta cinerea as a biological model. Sublethal doses of FPL (0.1-0.001 µg/g) increased the time spent grooming and caused dose-dependent inhibition of exploratory activity, partial neuromuscular blockade in vivo, and irreversible negative cardiac chronotropism. FPL also disrupted learning and olfactory memory formation at all doses tested. These results provide the first evidence that short-term exposure to sublethal concentrations of FPL can significantly disrupt insect behavior and physiology, including olfactory memory. These findings have implications for current pesticide risk assessment and could be potentially useful in establishing a correlation with pesticide effects in other insects, such as honey bees.

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Modulation of octopaminergic and cholinergic pathways induced by Caatinga tree Manilkara rufula chemical compounds in Nauphoeta cinerea cockroaches

Cited by 3 publications

References 39 publications

Probability that there is a mammalian counterpart of cardiac clock in insects

Probability that there is a mammalian counterpart of cardiac clock in insects

Persistent oxidative injury and neurobehavioral impairment in adult male and female Nauphoeta cinerea exposed to perfluorooctanoic acid

Fipronil affects cockroach behavior and olfactory memory

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