2018
DOI: 10.1038/s41598-018-22148-5
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Abstract: The increasing incidence of age-induced cognitive decline justifies the search for complementary ways of prevention or delay. We studied the effects of concentrates of phospholipids, sphingolipids, and/or 3-n fatty acids on the expression of genes or miRNAs related to synaptic activity and/or neurodegeneration, in the hippocampus of aged Wistar rats following a 3-month supplementation. The combination of two phospholipidic concentrates of krill oil (KOC) and buttermilk (BMFC) origin modulated the hippocampal e… Show more

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Cited by 19 publications
(10 citation statements)
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“…Diet supplementation with phospholipids and SM concentrates obtained from krill oil (KOC) and buttermilk (BMFC) and/or 3‐n fatty acids for 3 months altered the expression of genes or miRNAs related to synaptic activity and/or neuro degeneration in the hippocampus of aged Wistar rats (Crespo et al . 2018). This was attributed to the differential expression of genes (DEG), mainly involved in neuroactive processes, in groups receiving the KOC and BMFC supplements.…”
Section: Nutritional and Health Benefits Of Mfgmmentioning
confidence: 99%
“…Diet supplementation with phospholipids and SM concentrates obtained from krill oil (KOC) and buttermilk (BMFC) and/or 3‐n fatty acids for 3 months altered the expression of genes or miRNAs related to synaptic activity and/or neuro degeneration in the hippocampus of aged Wistar rats (Crespo et al . 2018). This was attributed to the differential expression of genes (DEG), mainly involved in neuroactive processes, in groups receiving the KOC and BMFC supplements.…”
Section: Nutritional and Health Benefits Of Mfgmmentioning
confidence: 99%
“…In mice, loss of Satb2 dysregulates the expression of multiple miRNAs involved in memory and synaptic plasticity (Jaitner et al, ). The effects of dietary supplementation with phospholipidic concentrates of krill oil and buttermilk on the expression of miRNAs in hippocampal neurons have been studied in murine models (Crespo et al, ). Finally, neurological defects in patients with SAS have been reported to share molecular and cellular mechanisms with other neurodevelopmental or neurodegenerative diseases, such as schizophrenia and Alzheimer's disease (Whitton et al, ).…”
Section: Future Prospectsmentioning
confidence: 99%
“…The second area where MFGM is being positioned is the prevention of several diseases including cardiovascular disease [ 12 ], impaired bone turnover and inflammation [ 13 ], skin conditions [ 14 ], and infection by E. coli [ 15 ], as well as age-associated diseases such as cognitive decline and muscle loss. Stemming from the observation that the phospholipid composition of MFGM is quite similar to that of neuronal cell membranes, some investigators are proposing the use of MFGM to counteract the loss of some neuronal components such as polyunsaturated fatty acids (PUFAs), namely those of the omega-3 series [ 16 , 17 , 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%