Modulation of mGlu5 reduces rewarding associative properties of nicotine via changes in mesolimbic plasticity: Relevance to comorbid cigarette smoking in psychosis

Peeters, Loren D.; Wills, Liza J.; Cuozzo, Anthony M.; Ivanich, Kira L.; Turney, Seth E.; Bullock, Luke P.; Price, Robert M.; Gass, Justin T.; Brown, Russell W.

doi:10.1016/j.pbb.2024.173752

Pharmacology Biochemistry and Behavior

2024

DOI: 10.1016/j.pbb.2024.173752

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Modulation of mGlu5 reduces rewarding associative properties of nicotine via changes in mesolimbic plasticity: Relevance to comorbid cigarette smoking in psychosis

Loren D. Peeters,

Liza J. Wills,

Anthony M. Cuozzo

et al.

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Nicotine’s Effects on Schizophrenia-like Symptoms in a Mice Model: Time Matters

Dutra-Tavares,

Couto,

Souza

et al. 2024

Brain Sciences

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Tobacco consumption in schizophrenia (SCHZ) patients is highly prevalent. Data support the occurrence of sequential events during comorbidity establishment, and both smoking first, SCHZ second and SCHZ first, smoking second sequences have been proposed. To investigate whether these two possibilities lead to distinct outcomes of comorbidity, we used a phencyclidine-induced SCHZ model and nicotine exposure as a surrogate of smoking. C57Bl/6 mice were submitted to a protocol that either began with 4 days of phencyclidine exposure or 4 days of nicotine exposure. This period was followed by 5 days of combined phencyclidine + nicotine exposure. Locomotor sensitization and pre-pulse inhibition (PPI) were assessed due to their well-known associations with SCHZ as opposed to rearing, an unrelated behavior. Nicotine priming potentiated phencyclidine-evoked sensitization. However, nicotine exposure after SCHZ modeling did not interfere with phencyclidine’s effects. In the PPI test, nicotine after SCHZ modeling worsened the phencyclidine-evoked deficiency in males. In contrast, nicotine priming had no effects. Regarding rearing, nicotine priming failed to interfere with phencyclidine-mediated inhibition. Similarly, phencyclidine priming did not modify nicotine-mediated inhibition. The present results indicate that the sequence, either SCHZ-first or nicotine-first, differentially impacts comorbidity outcomes, a finding that is relevant for the identification of mechanisms of nicotine interference in the neurobiology of SCHZ.

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Nicotine’s Effects on Schizophrenia-like Symptoms in a Mice Model: Time Matters

Dutra-Tavares,

Couto,

Souza

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

show abstract

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Modulation of mGlu5 reduces rewarding associative properties of nicotine via changes in mesolimbic plasticity: Relevance to comorbid cigarette smoking in psychosis

Cited by 1 publication

References 91 publications

Nicotine’s Effects on Schizophrenia-like Symptoms in a Mice Model: Time Matters

Nicotine’s Effects on Schizophrenia-like Symptoms in a Mice Model: Time Matters

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