Modulation of IL-17A and TL1A largely abrogates house dust mite-induced lung inflammation in murine model of allergic airway disease

Hubeau, Cédric; Kubera, John; Hammerman, Katherine; Denz, Michelle; Yt, Juang; Williams, Cara

doi:10.1186/1476-9255-10-s1-p3

Cited by 2 publications

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“…Our findings support the conclusion that both pathways of inflammation are activated in this model, parallel to the findings of other investigators. For instance, Hubeaue et al showed that mice develop robust IL‐17 responses after several weeks of HDM exposure. In the purified OVA‐induced asthma model, which only elicits Th2 responses, Th17 inflammation was activated only after additional exposure to HDM, further supporting HDM's ability to induce Th17 inflammation .…”

Section: Discussionmentioning

confidence: 99%

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

Gavino

Nahmod

Bharadwaj

et al. 2016

Allergy

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Section: Discussionmentioning

confidence: 99%

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

Gavino

Nahmod

Bharadwaj

et al. 2016

Allergy

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“…In the HDM model, effects on converging IL‐1β and IL‐17 signalling in lung pathology may thus be more important. Certainly, the latter cytokine has been reported to play a key role in the HDM model , which makes the failure of SMA 11a – an SMA known to target IL‐17 responses – somewhat surprising.…”

Section: Discussionmentioning

confidence: 99%

Testing small molecule analogues of the Acanthocheilonema viteae immunomodulator ES‐62 against clinically relevant allergens

Janicova

Rzepecka

Rodgers

et al. 2016

Parasite Immunology

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Summary ES‐62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)‐induced airway hyper‐responsiveness in mice by virtue of covalently attached anti‐inflammatory phosphorylcholine (PC) residues. We have recently generated a library of small molecule analogues (SMAs) of ES‐62 based around its active PC moiety as a starting point in novel drug development for asthma and identified two compounds – termed 11a and 12b – that mirror ES‐62's protective effects. In this study, we have moved away from OVA, a model allergen, to test the SMAs against two clinically relevant allergens – house dust mite (HDM) and cockroach allergen (CR) extract. We show that both SMAs offer some protection against development of lung allergic responses to CR, in particular reducing eosinophil infiltration, whereas only SMA 12b is effective in protecting against eosinophil‐dependent HDM‐induced allergy. These data therefore suggest that helminth molecule‐induced protection against model allergens may not necessarily translate to clinically relevant allergens. Nevertheless, in this study, we have managed to demonstrate that it is possible to produce synthetic drug‐like molecules based on a parasitic worm product that show therapeutic potential with respect to asthma resulting from known triggers in humans.

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Modulation of IL-17A and TL1A largely abrogates house dust mite-induced lung inflammation in murine model of allergic airway disease

Cited by 2 publications

References 0 publications

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

Testing small molecule analogues of the Acanthocheilonema viteae immunomodulator ES‐62 against clinically relevant allergens

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