Modulation of Hippocampal Activity by Vagus Nerve Stimulation in Freely Moving Rats

Larsen, Lars Emil; Wadman, Wytse J.; Mierlo, Pieter van; Delbeke, Jean; Grimonprez, Annelies; Nieuwenhuyse, Bregt Van; Portelli, Jeanelle; Boon, Paul; Vonck, Kristl; Raedt, Robrecht

doi:10.1016/j.brs.2015.09.009

Cited by 21 publications

(16 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dentate field EPs allow us to study excitability, which is an important element in epilepsy [14]. In addition, we found that VNS decreases hippocampal EEG power in various frequency bands [12], reflecting reduced magnitude and/or synchrony of both local and global hippocampal activity [15].…”

Section: Introductionmentioning

confidence: 72%

“…1). Two types of VNS duty cycles were investigated: a standard VNS duty cycle (30 s on and 300 s off) and a rapid VNS duty cycle (7 s on, 18 s off) [12,21], which is often used to treat patients not responding to the former scheme [5,22]. Two standard cycle conditions were included with VNS applied at intensities of 1000 μA (S1000) and 250 μA (S250).…”

Section: Recording Sessionsmentioning

confidence: 99%

“…On consecutive days, rapid cycle recording sessions were performed using VNS intensities ramped up in daily 25 μA increments from 0 to 250 μA (day 1-11), in daily increments of 50 μA from 300 μA to 500 μA (day [12][13][14][15][16], and up to 1000 μA in a final recording session (day 17). In this experiment, only hippocampal EEG was acquired.…”

Section: Recording Sessionsmentioning

confidence: 99%

“…The effect of VNS on different electrophysiological phenomena is now increasingly being investigated in order to understand mechanisms of VNS at a neurophysiological level [7][8][9][10][11][12]. We previously found in rats that rapid-cycle (7 s on, 18 s off) VNS at 1000 μA modulates dentate gyrus fieldevoked potentials (EPs) induced by stimulation of the perforant path, an afferent fiber bundle projecting to the hippocampus [12].…”

Section: Introductionmentioning

confidence: 99%

“…We previously found in rats that rapid-cycle (7 s on, 18 s off) VNS at 1000 μA modulates dentate gyrus fieldevoked potentials (EPs) induced by stimulation of the perforant path, an afferent fiber bundle projecting to the hippocampus [12]. Dentate field EPs consist of a field excitatory postsynaptic potential (fEPSP), reflecting depolarization of dentate granule cells in response to afferent stimulation.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle

et al. 2016

Self Cite

View full text Add to dashboard Cite

Although vagus nerve stimulation (VNS) is widely used, therapeutic mechanisms and optimal stimulation parameters remain elusive. In the present study, we investigated the effect of VNS on hippocampal field activity and compared the efficiency of different VNS paradigms. Hippocampal electroencephalography (EEG) and perforant path dentate field-evoked potentials were acquired before and during VNS in freely moving rats, using 2 VNS duty cycles: a rapid cycle (7 s on, 18 s off) and standard cycle (30 s on, 300 s off) and various output currents. VNS modulated the evoked potentials, reduced total power of the hippocampal EEG, and slowed the theta rhythm. In the hippocampal EEG, theta (4-8 Hz) and high gamma (75-150 Hz) activity displayed strong phase amplitude coupling that was reduced by VNS. Rapid-cycle VNS had a greater effect than standard-cycle VNS on all outcome measures. Using rapid cycle VNS, a maximal effect on EEG parameters was found at 300 μA, beyond which effects saturated. The findings suggest that rapid-cycle VNS produces a more robust outcome than standard cycle VNS and support already existing preclinical evidence that relatively low output currents are sufficient to produce changes in brain physiology and thus likely also therapeutic efficacy.

show abstract

Section: Introductionmentioning

confidence: 72%

Section: Recording Sessionsmentioning

confidence: 99%

Section: Recording Sessionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

Optogenetic Manipulation of the Vagus Nerve

Okonogi

Sasaki

2021

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Invasive Neuromodulation for the Treatment of Pediatric Epilepsy

2019

View full text Add to dashboard Cite

Neuromodulatory strategies are increasingly adopted for the treatment of intractable epilepsy in children. These encompass a wide range of treatments aimed at externally stimulating neural circuitry in order to decrease seizure frequency. In the current review, the authors discuss the evidence for invasive neuromodulation, namely vagus nerve and deep brain stimulation in affected children. Putative mechanisms of action and biomarkers of treatment success are explored and evidence of the efficacy of invasive neuromodulation is highlighted.

show abstract

Modulation of Hippocampal Activity by Vagus Nerve Stimulation in Freely Moving Rats

Cited by 21 publications

References 38 publications

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle

Optogenetic Manipulation of the Vagus Nerve

Invasive Neuromodulation for the Treatment of Pediatric Epilepsy

Contact Info

Product

Resources

About