2013
DOI: 10.1111/imm.12049
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Abstract: SummaryModulation and suppression of the immune response of the host by nematode parasites have been reported extensively and the cysteine protease inhibitor (CPI or cystatin) is identified as one of the major immunomodulators. In the present study, we cloned and produced recombinant CPI protein from the murine nematode parasite Heligmosomoides polygyrus (rHp-CPI) and investigated its immunomodulatory effects on dendritic cell (DC) function and immune responses in mice. Bone-marrow-derived CD11c + DC (BMDC) th… Show more

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Cited by 58 publications
(51 citation statements)
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“…4B). In contrast to most studied protease inhibitors that were found to be immunoregulatory and anti-inflammatory (43)(44)(45), U-Omp19 has inflammatory properties, as it induces the activation of DCs and recruitment of APCs at inductive sites. Analysis of NF-kB activation in HEK293 reporter cells expressing a given TLR/Nod-like receptor (InvivoGen pattern recognition receptor ligand screening service) demonstrated that U-Omp19 does not signal through The Journal of Immunology 4027…”
Section: Discussionmentioning
confidence: 94%
See 1 more Smart Citation
“…4B). In contrast to most studied protease inhibitors that were found to be immunoregulatory and anti-inflammatory (43)(44)(45), U-Omp19 has inflammatory properties, as it induces the activation of DCs and recruitment of APCs at inductive sites. Analysis of NF-kB activation in HEK293 reporter cells expressing a given TLR/Nod-like receptor (InvivoGen pattern recognition receptor ligand screening service) demonstrated that U-Omp19 does not signal through The Journal of Immunology 4027…”
Section: Discussionmentioning
confidence: 94%
“…Thus, we demonstrated that potent cysteine protease inhibitors such as leupeptin or human cystatin C are able to reduce degradation of Ags but are not inductors of CD8 + T cell immune responses. Furthermore, it has been suggested that cystatin-type molecules secreted from parasites downmodulate the host immune response (43)(44)(45). Thus, every protease inhibitor, depending on its particular structure, mechanism of action, and potency, may have different immunomodulatory properties that should be studied in detail.…”
Section: Discussionmentioning
confidence: 99%
“…Subsequently, inflammatory cytokines are released (9), and innate immune cells, including dendritic cells (10), are activated and play an important role in shaping humoral immunity (11). The double-stranded and single-stranded viral RNAs resulting from a WNV infection are recognized by TLR3 and TLR7/8, respectively.…”
mentioning
confidence: 99%
“…Increased expression of costimulatory molecules supports the idea that inhibitory signals are also delivered by CD80 and CD86 to T cells to prevent their differentiation and also for induction of regulatory T cells (38). While increased TNF-␣ secretion has been linked to DC maturation (35), the fact that not all DC subsets showed similar expression patterns of maturation and costimulatory markers or had similarly modulated antigen uptake and presentation capacities suggests that some other factors, possibly excretory-secretory products released by the infective larvae, might have been responsible for the phenomenon (5,39,40). Importantly, support for this notion is evident from the work carried out by Everts et al, who showed that human mDCs infected with Schistosoma haematobium had lower levels of HLA-DR expression than those of uninfected individuals (8).…”
Section: Discussionmentioning
confidence: 99%