Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: A resting-state EEG and TMS-EEG study

Gordon, Pedro Caldana; Zrenner, Christoph; Desideri, Debora; Belardinelli, Paolo; Zrenner, Brigitte; Brunoni, André R.; Ziemann, Ulf

doi:10.1016/j.brs.2018.06.004

Cited by 56 publications

(44 citation statements)

References 59 publications

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“…Alternatively, reaction times (RTs) could be used as a behavioural index of alertness in active TMS experiments, as RTs typically lengthen with decreases in vigilance (Schmidt et al, 2009), increases in drowsiness (Ogilvie & Wilkinson, 1984), and following sleep deprivation (Ratcliff & Van Dongen, 2011). However, such a strategy would not be possible in passive paradigms in which participants are not required to respond (Gordon et al, 2018;Massimini et al, 2005). Furthermore, as both trial counts and reaction times are relative measures, participants who maintain high alertness throughout a session could be falsely labelled as drowsy in a proportion of trials.…”

Section: Discussionmentioning

confidence: 99%

Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation

Noreika

Kamke

Canales‐Johnson

et al. 2017

Preprint

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Transcranial magnetic stimulation (TMS) has been widely used in human cognitive neuroscience to examine the causal role of distinct cortical areas in perceptual, cognitive and motor functions. However, it is widely acknowledged that the effects of focal cortical stimulation on behaviour can vary substantially between participants and even from trial to trial within individuals. Here we asked whether spontaneous fluctuations in alertness can account for the variability in behavioural and neurophysiological responses to TMS. We combined single-pulse TMS with neural recording via electroencephalography (EEG) to quantify changes in motor and cortical reactivity with fluctuating levels of alertness defined objectively on the basis of ongoing brain activity. We observed rapid, non-linear changes in TMS-evoked neural responses – specifically, motor evoked potentials and TMS-evoked cortical potentials – as EEG activity indicated decreasing levels of alertness, even while participants remained awake and responsive in the behavioural task.IMPACT STATEMENTA substantial proportion of inter-trial variability in neurophysiological responses to TMS is due to spontaneous fluctuations in alertness, which should be controlled for during experimental and clinical applications of TMS.

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Section: Discussionmentioning

confidence: 99%

Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation

Noreika

Kamke

Canales‐Johnson

et al. 2017

Preprint

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“…Background noise can have differential effects on task performance between experimental groups, such as children diagnosed with ADHD vs healthy controls [32], introverts vs extroverts [33], and can affect performance on cognitive vs. perceptual tasks differently [34]. For studies that do not use active sound masking methods [4,35], our results indicate that early-latency (<80 ms) TEPs are reliably location specific.…”

Section: Discussionmentioning

confidence: 87%

Identifying site- and stimulation-specific TMS-evoked EEG potentials using a quantitative cosine similarity metric

Freedberg

Reeves

Hussain

et al. 2019

Preprint

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25 The ability to interpret transcanial magnetic stimulation (TMS) evoked EEG potentials (TEPs) is limited 26 by artifacts, such as auditory evoked responses produced by the TMS coil. TEPs generated from direct 27 cortical stimulation should vary in spatial distribution with stimulation site and from responses to sham 28 stimulation. Responses that do not show these effects are likely to be artifactual. In 20 healthy volunteers, 29 we delivered active and sham TMS to right prefrontal, left primary motor, and left posterior parietal 30 cortex and compared the waveform similarity of TEPs between stimulation sites and active and sham 31 TMS with a cosine similarity-based analysis method. We looked for epochs after the stimulus when the 32 spatial pattern of TMS-evoked activation had greater than random similarity between stimulation sites 33 and sham vs. active TMS, indicating presence of a dominant artifact, such as the auditory brain response. 34 We calculated and binarized the derivatives of the TEPs recorded from 30 EEG channels and calculated 35 cosine similarity between conditions at each time point with millisecond resolution. Only TEP 36 components occurring before approximately 80 ms differed across stimulation sites and between active 37 and sham, indicating site and condition-specific responses. TEP components before about 80 ms can be 38 safely interpreted as stimulation location-specific responses to TMS, but components beyond this latency 39 should be interpreted with caution due to high similarity in their spatial distribution. 3 40 Introduction 41 Transcranial magnetic stimulation (TMS)-evoked EEG potentials (TEPs) are a rich source of 42 neurophysiological data, and can be used to study cortical excitability and effective connectivity [1]. 43 TEPs are obtained by activating the cortex with TMS and measuring the response with 44 electroencephalography (EEG) across the scalp. TEPs have been used to study a variety of phenomena, 45 including consciousness [2,3], memory [4], and the pathophysiology of neurological disorders [5-7]. 46 A major factor limiting the interpretation of the EEG response to TMS is the presence of time-47 locked artifacts. Artifacts from sources outside of the brain, such as electrode noise and recharge artifacts 130 we removed one channel per participant for each stimulation condition (minimum = 0; maximum = 3). 131 We baseline-corrected each epoch by whole-epoch de-meaning and then performed two rounds of ICA to 132 detect and remove artifacts. Both rounds used the FastICA algorithm [23] with a symmetric 133 decomposition approach and hyperbolic tangent contrast function. The first round of ICA included an 134 automated artifact detection algorithm (tesa_compselect) [8] to remove large pulse-related artifacts. The 135 second round was performed to eliminate small artifacts not rejected during the first round. To obtain a 136 consensus about which components should be rejected, authors JR, SH, and MF performed agreement 137 training on a test data set. Each author individually p...

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“…Entretanto, mudanças na densidade da corrente utilizada tem efeito sobre a mudança de excitabilidade cortical, com maiores densidades levando a efeito mais robusto Nitsche et al, 2007). Tal efeito também foi observado em ETCC dirigida ao córtex pré-frontal (Gordon et al, 2018;Hill, Rogasch, Fitzgerald, & Hoy, 2017), sugerindo que maiores densidades de corrente aplicadas sobre o córtex pré-frontal apresentam maior eficácia no que diz respeito a efeitos neuromodulatórios.…”

Section: Excitabilidade Cortical Motora Em Sujeitos Com Esquizofreniaunclassified

“…inibição intracortical, por exemplo, com diminuição da magnitude de oscilações corticais de banda gama(Gordon et al, 2018;Hill et al, 2017). Ambos SICI e oscilações corticais de banda gama tem o mesmo mecanismo em comum, mais especificamente a atividade sincrônica de interneurônios GABA A(Lisman & Jensen, 2013).…”

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“…As dinâmicas da ECM, ao contrário, têm sido estudadas há mais tempo, de forma que os resultados encontrados em estudo com a técnica são de mais fácil interpretação e correspondência com mecanismos neurofisiológicos.Ademais, apesar do principal alvo da ETCC no presente estudo não ter sido o córtex motor primário, como demonstrado em sessão anterior, tal região apresentou pico de intensidade do campo elétrico induzido pela estimulação, o que permitiu modulação da excitabilidade cortical observada por meio de ECM(Rawji et al, 2018). Por fim, os resultados encontrados no presente estudo, especificamente estimulação anódica em CPFDL levando ao aumento da inibição intracortical devido a aumento do SICI, corresponde a achados prévios em sujeitos saudáveis, analisados por meio de EMT EEG(Gordon et al, 2018;Hill et al, 2017).Finalmente, não foi possível no presente momento responder à questão relativa à correlação do aumento da inibição intracortical com evolução do quadro clínico em resposta a terapia com ETCC, dada a indisponibilidade dos dados quando da formulação desse documento.…”

Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: A resting-state EEG and TMS-EEG study

Cited by 56 publications

References 59 publications

Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation

Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation

Identifying site- and stimulation-specific TMS-evoked EEG potentials using a quantitative cosine similarity metric

Excitabilidade cortical motora como preditora de resposta na esquizofrenia

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