Modulation of copper accumulation and copper-induced toxicity by antioxidants and copper chelators in cultured primary brain astrocytes

Stabilization of Aliphatic Phosphines by Auxiliary Phosphine Sulfides Offers Zeptomolar Affinity and Unprecedented Selectivity for Probing Biological CuI

“…By comparison, the membrane-permeant Zn(II)-selective chelator TPEN [15] resulted in a dramatically reduced viability at concentrations as low as 5–10 μM under otherwise identical conditions. Consistent with previous observations that selective removal of copper from the growth medium had little effect on the viability of cultured cells, [16] the low cytotoxicity of PSP-2 suggests that the ligand cannot sequester copper from metalloproteins whose function is essential for cellular survival.…”

Safe-by-Design CuO NanoparticlesviaFe-Doping, Cu–O Bond Length Variation, and Biological Assessment in Cells and Zebrafish Embryos

“…They suggested the attempts of rescuing brain cells against copper-induced ROS exploiting Cu-chelators are highly risky. 37 In very recent reports, Hedberg et al showed cellular membrane damage due to NP corrosion which helped accelerate dissolution. 76 In addition, the dissolution of CuO NPs caused specific developmental effects in sea urchin embryos due to disruption in the aboral-oral axis related to altered gene expression induced by changes in the redox environment.…”

“…The Cu-chelators used in the treatment reduce Cu 2+ to Cu + and enhance copper accumulation inducing toxicity in the brain. 37 Human exposure to CuO NPs is capable of inducing oxidative stress and acute inflammatory effects in the lungs of exposed welders, giving rise to a condition known as metal fumed fever. 38–41 Studies on zebrafish embryos also demonstrated that CuO NPs are capable of interfering in embryo hatching as a result of the inhibitory effects of released copper ions on the metalloprotease enzyme, ZHE1, secreted by the hatching gland.…”

Bee glue (propolis) improves reproductive organs, sperm quality and histological changes and antioxidant parameters of testis tissues in rats exposed to excess copper

“…Copper (Cu) is an important trace element playing role like cofactor in various enzymes and metabolic pathways such as antioxidant defence and mitochondrial respiration (Bulcke, Santofimia‐Castaño, Gonzalez‐Mateos, & Dringen, ). On the other hand, the accumulation of Cu more than the metabolic requirements or disorders in Cu homeostasis can cause appearing its toxic effects (Fuentealba & Aburto, ).…”

“…Excessive Cu is able to induce oxidative stress by increasing the formation of reactive oxygen species (ROS) that leads to peroxidative degradation of polyunsaturated fatty acids (PUFAs) (Halliwell & Gutteridge, ; Mladenović et al, ). In the recent researches have been shown to be useful effects of antioxidants on ROS‐mediated toxicity (Bulcke et al, ; Lushchak, ; Poljsak & Fink, ). However, it has been reported that antioxidants might also behaviour like a pro‐oxidant in the existence of a transition metal like Cu (Bulcke et al, ).…”