Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rat

Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice

“…In response to GdCl 3 treatment, elevations in MT induction have been observed by others (Andrés et al, 2003;Harstad and Klaassen, 2002;Sauer and Sipes, 1995) and these changes were virtually independent of the noxious stimulus in our study. It is conceivable that the mechanisms of MT induction in endotoxemia and after GdCl 3 are different.…”

“…The present study reveals some toxic aspects of GdCl 3 , such as enhanced LPO and DNA damage, independently of the various challenges, but no microcirculatory deterioration. On the other hand, most reports attribute protective features to GdCl 3 such as an alleviation of cadmium chloride (Harstad and Klaassen, 2002) or retinol (Sauer and Sipes, 1995) toxicity. We earlier reported that GdCl 3 ameliorates the microcirculatory and structural consequences of endotoxemia and obstructive jaundice, also reducing inflammatory cytokine release (TNF and IL-6) (Lázár et al, 2002;Abrahám et al, 2008).…”

Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice

“…In response to GdCl 3 treatment, elevations in MT induction have been observed by others (Andrés et al, 2003;Harstad and Klaassen, 2002;Sauer and Sipes, 1995) and these changes were virtually independent of the noxious stimulus in our study. It is conceivable that the mechanisms of MT induction in endotoxemia and after GdCl 3 are different.…”

“…The present study reveals some toxic aspects of GdCl 3 , such as enhanced LPO and DNA damage, independently of the various challenges, but no microcirculatory deterioration. On the other hand, most reports attribute protective features to GdCl 3 such as an alleviation of cadmium chloride (Harstad and Klaassen, 2002) or retinol (Sauer and Sipes, 1995) toxicity. We earlier reported that GdCl 3 ameliorates the microcirculatory and structural consequences of endotoxemia and obstructive jaundice, also reducing inflammatory cytokine release (TNF and IL-6) (Lázár et al, 2002;Abrahám et al, 2008).…”

Suppression of Arylamine Toxicity in the Fischer-344 Rat Following Ingestion of a Complex Mixture

“…The major source of human exposure to environmental PAH contaminants on a daily weight basis is from the diet (64). This exposure pathway is consistent with a large pool of epidemiological data linking the incidence of human cancer (20-50%) and disease with dietary factors (4,10,37,38,56,63,65). Other general and speci c studies have supported this view (38,47,70).…”

“…More often, they are exposed to combinations of compounds, either concurrently or sequentially, which can have differing effects on individual cells and organ systems (56). The interactions of differing compounds can in uence toxicity of individual compounds.…”

Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation

“…Because PIMs are difficult to isolate (34), we depleted them with GC to investigate ALI in their absence and to compare with hosts with intact PIMs. Many investigators have used GC to selectively remove alveolar and liver macrophages to investigate their functions (7,32,34,43). Because phagocytosis of GC is a prerequisite for its efficacy, macrophages become its prime targets (19,20,43).…”

Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice

“…In response to GdCl 3 treatment, elevations in MT induction have been observed by others (Andrés et al, 2003;Harstad and Klaassen, 2002;Sauer and Sipes, 1995) and these changes were virtually independent of the noxious stimulus in our study. It is conceivable that the mechanisms of MT induction in endotoxemia and after GdCl 3 are different.…”

“…The present study reveals some toxic aspects of GdCl 3 , such as enhanced LPO and DNA damage, independently of the various challenges, but no microcirculatory deterioration. On the other hand, most reports attribute protective features to GdCl 3 such as an alleviation of cadmium chloride (Harstad and Klaassen, 2002) or retinol (Sauer and Sipes, 1995) toxicity. We earlier reported that GdCl 3 ameliorates the microcirculatory and structural consequences of endotoxemia and obstructive jaundice, also reducing inflammatory cytokine release (TNF and IL-6) (Lázár et al, 2002;Abrahám et al, 2008).…”

Suppression of Arylamine Toxicity in the Fischer-344 Rat Following Ingestion of a Complex Mixture

“…The major source of human exposure to environmental PAH contaminants on a daily weight basis is from the diet (64). This exposure pathway is consistent with a large pool of epidemiological data linking the incidence of human cancer (20-50%) and disease with dietary factors (4,10,37,38,56,63,65). Other general and speci c studies have supported this view (38,47,70).…”

“…More often, they are exposed to combinations of compounds, either concurrently or sequentially, which can have differing effects on individual cells and organ systems (56). The interactions of differing compounds can in uence toxicity of individual compounds.…”

Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation

“…Because PIMs are difficult to isolate (34), we depleted them with GC to investigate ALI in their absence and to compare with hosts with intact PIMs. Many investigators have used GC to selectively remove alveolar and liver macrophages to investigate their functions (7,32,34,43). Because phagocytosis of GC is a prerequisite for its efficacy, macrophages become its prime targets (19,20,43).…”

Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice

“…In response to GdCl 3 treatment, elevations in MT induction have been observed by others (Andrés et al, 2003;Harstad and Klaassen, 2002;Sauer and Sipes, 1995) and these changes were virtually independent of the noxious stimulus in our study. It is conceivable that the mechanisms of MT induction in endotoxemia and after GdCl 3 are different.…”

“…The present study reveals some toxic aspects of GdCl 3 , such as enhanced LPO and DNA damage, independently of the various challenges, but no microcirculatory deterioration. On the other hand, most reports attribute protective features to GdCl 3 such as an alleviation of cadmium chloride (Harstad and Klaassen, 2002) or retinol (Sauer and Sipes, 1995) toxicity. We earlier reported that GdCl 3 ameliorates the microcirculatory and structural consequences of endotoxemia and obstructive jaundice, also reducing inflammatory cytokine release (TNF and IL-6) (Lázár et al, 2002;Abrahám et al, 2008).…”

Suppression of Arylamine Toxicity in the Fischer-344 Rat Following Ingestion of a Complex Mixture

“…The major source of human exposure to environmental PAH contaminants on a daily weight basis is from the diet (64). This exposure pathway is consistent with a large pool of epidemiological data linking the incidence of human cancer (20-50%) and disease with dietary factors (4,10,37,38,56,63,65). Other general and speci c studies have supported this view (38,47,70).…”

“…More often, they are exposed to combinations of compounds, either concurrently or sequentially, which can have differing effects on individual cells and organ systems (56). The interactions of differing compounds can in uence toxicity of individual compounds.…”

Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation

“…Because PIMs are difficult to isolate (34), we depleted them with GC to investigate ALI in their absence and to compare with hosts with intact PIMs. Many investigators have used GC to selectively remove alveolar and liver macrophages to investigate their functions (7,32,34,43). Because phagocytosis of GC is a prerequisite for its efficacy, macrophages become its prime targets (19,20,43).…”