Modulation of 5-HT and proctolin receptors by FMRFamide in the foregut of the locust Schistocerca gregaria

Banner, S.E.; Osborne, Richard H.

doi:10.1016/0022-1910(89)90105-4

Cited by 28 publications

(13 citation statements)

References 15 publications

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“…The tetrapeptide FMRFamide causes contraction of the locust foregut in vitro. FMRFamide also inhibited proctolin-induced contraction and potentiates 5-HT induced relaxation of the foregut (Banner and Osborne 1989). In D. melanogaster, the FMRFamide tetrapeptide affected crop contractions, although the endogenous, N-terminally extended, FMRFamides had no effect (Duttlinger et al 2002).…”

Section: Fmrfamide-like Peptidesmentioning

confidence: 99%

“…Evidence exists that proctolin stimulates muscle contractions in foregut, midgut and (or) hindgut of some locust and cockroach species (Banner and Osborne 1989;Lange et al 1993;Fusé and Orchard 1998;Lange and Orchard 1998;Gray et al 2000). The release of the D. melanogaster genome sequence allowed for the identification of both a proctolin precursor (Taylor et al 2004) and a receptor (Egerod et al 2003;Johnson et al 2003) from this organism.…”

Section: Proctolinmentioning

confidence: 99%

“…Different members of these peptide families display strong modulating effects on the activity of visceral muscles in insects. They are able to inhibit contractions of heart and skeletal muscles (Robb and Evans 1994), oviduct (Peeff et al 1994), foregut (Banner and Osborne 1989), midgut (Lange and Orchard 1998), and salivary glands (Orchard and Te Brugge 2002). They also modulate the release of digestive enzymes (Harshini et al 2002;Schoofs and Nachman 2006) and influence feeding behavior (Wei et al 2000;Nagata et al 2011).…”

Section: Fmrfamide-like Peptidesmentioning

confidence: 99%

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Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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Like all heterotrophic organisms, insects require a strict control of food intake and efficient digestion of food into nutrients to maintain homeostasis and to fulfill physiological tasks. Feeding and digestion are steered by both external and internal signals that are transduced by a multitude of regulatory factors, delivered either by neurons innervating the gut or mouthparts, or by midgut endocrine cells. The present review gives an overview of peptide regulators known to control feeding and digestion in insects. We describe the discovery and functional role in these processes for insect allatoregulatory peptides, diuretic hormones, FMRFamide-related peptides, (short) neuropeptide F, proctolin, saliva production stimulating peptides, kinins, and tachykinins. These peptides control either gut myoactivity, food intake, and (or) release of digestive enzymes. Some peptides exert their action at multiple levels, possibly having a biological function that depends on their site of delivery. Many regulatory peptides have been physically extracted from different insect species. However, multiple peptidomics, proteomics, transcriptomics, and genome sequencing projects have led to increased discovery and prediction of peptide (precursor) and receptor sequences. In combination with physiological experiments, these large-scale projects have already led to important steps forward in unraveling the physiology of feeding and digestion in insects.Key words: insect, midgut, digestion, neuropeptides, stomatogastric nervous system. Résumé : Comme tous les organismes hétérotrophes, les insectes requièrent un contrôle strict de leur ingestion de nourriture et la digestion de leur nourriture en nutriments afin de maintenir leur homéostasie et de compléter leurs tâches physiologiques. L'alimentation et la digestion sont gouvernées par des signaux tant externes qu'internes qui sont transmis par un multitude de facteurs régulateurs, livrés ou bien par les neurones qui innervent le tube digestif ou les pièces buccales ou alors par les cellules endocrines du tube digestif moyen. Notre revue fournit une synthèse des régulateurs peptidiques connus pour contrôler l'alimentation et la digestion chez les insectes. Nous décrivons la découverte et le rôle fonctionnel de ces processus dans le cas des peptides allatorégulateurs, des hormones diurétiques, des peptides apparentés aux amides FMRF, du neuropeptide F (court), de la proctoline, des peptides stimulateurs de la production de salive, des kinines et des tachykinines des insectes. Ces peptides contrôlent la myoactivité du tube digestif, l'ingestion de nourriture et(ou) la libération des enzymes digestives. Certains peptides agissent à de multiples niveaux, possédant une fonction biologique qui dépend de leur site d'action. Plusieurs peptides régulateurs ont été extraits physiquement de différentes espèces d'insectes. Cependant, plusieurs projets de peptidomique, de protéomique, de transcriptomique et de génomique ont mené à de nombreuses découvertes supplémentaires et des prédict...

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Section: Fmrfamide-like Peptidesmentioning

confidence: 99%

Section: Proctolinmentioning

confidence: 99%

Section: Fmrfamide-like Peptidesmentioning

confidence: 99%

See 1 more Smart Citation

Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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“…Since its discovery, proctolin has been found to have a stimulatory effect on the gut of several insect species including the locust midgut and foregut (Lange et al, 1988;Banner et al, 1987). Lastly, the FMRFamide-related peptides referred to as myosuppressins have an inhibitory effect on contraction of the gut regions, including the foregut and midgut of the locust (Banner and Osborne, 1989;Lange and Orchard, 1998).…”

Section: Introductionmentioning

confidence: 99%

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Robertson

Rodriguez

Lange

2012

Journal of Experimental Biology

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“…From these studies, and with the application of available bioassays, the physiological relevance of FaRPs is becoming clearer. It is known for instance, that FaRPs potentiate neurally-evoked contractions of the locust extensor tibiae (Walther et al 1984;Evans and Myers 1986), inhibit myogenic contractions of locust oviducts (Lange et al 1991;Peeff et al 1993) and may modulate the actions of biogenic amines on visceral tissues (Banner and Osborne 1989).…”

Section: Introductionmentioning

confidence: 99%

The distribution and partial characterization of FMRFamide-related peptides in the salivary glands of the locust, Locusta migratoria

Fusé

Ali

Orchard

1996

Cell and Tissue Research

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The distribution and partial characterization of FMRFamide-related peptides in the salivary glands of the locust, Locusta migratoria, were investigated by means of immunohistochemistry, radioimmunoassay and reversed-phase high performance liquid chromatography. Whole-mount preparations of glands stained positively against anti-FMRFamide antisera, and contained the equivalent of 837 +/- 80 fmol FMRFamide/gland pair, as determined by radioimmunoassay. FMRFamide-like immunoreactivity occurred in the processes of the transverse nerves of both the prothoracic and mesothoracic ganglia, but was not found in the salivary motoneurons 1 or 2 of the suboesophageal ganglion, both of which directly innervate the salivary glands via the salivary nerve 7b; nor was it found within the salivary nerve 7b itself, leading to the salivary glands. It was, however, found as a superficial nerve plexus on the surface of nerve 7 at the suboesophageal ganglion, but did not appear to extend to the salivary glands. The origin of this staining is unclear. High performance liquid chromatography of salivary gland tissue extracts, monitored by radioimmunoassay, revealed 4 peaks of immunoreactive material, 2 of which co-migrated with AFIRFamide and GQERNFLRFamide, previously isolated from the locust ventral nerve cord. These 2 synthetic peptides did not elevate basal levels of the second messengers cyclic AMP or cyclic GMP in the salivary glands.

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Modulation of 5-HT and proctolin receptors by FMRFamide in the foregut of the locust Schistocerca gregaria

Cited by 28 publications

References 15 publications

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

The distribution and partial characterization of FMRFamide-related peptides in the salivary glands of the locust, Locusta migratoria

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