Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing

Abstract

More and more studies have recognized that the nanosized pores of hydrogels are too small for cells to normally grow and newly formed tissue to infiltrate, which impedes tissue regeneration. Recently, hydrogels with macropores and/or controlled degradation attract more and more attention for solving this problem. Sodium alginate/Bioglass (SA/BG) hydrogel, which has been reported to be an injectable and bioactive hydrogel, is also limited to be used as tissue engineering scaffolds due to its nanosized pores. Therefore, in this study, degradation of SA/BG hydrogel was modulated by grafting deferoxamine (DFO) to SA. The functionalized grafted DFO-SA (G-DFO-SA) was used to form G-DFO-SA/BG injectable hydrogel. In vitro degradation experiments proved that, compared to SA/BG hydrogel, G-DFO-SA/BG hydrogel had a faster mass loss and structural disintegration. When the hydrogels were implanted subcutaneously, G-DFO-SA/BG hydrogel possessed a faster degradation and better tissue infiltration as compared to SA/BG hydrogel. In addition, in a rat full-thickness skin defect model, wound healing studies showed that, G-DFO-SA/BG hydrogel significantly accelerated wound healing process by inducing more blood vessels formation. Therefore, G-DFO-SA/BG hydrogel can promote tissue infiltration and stimulate angiogenesis formation, which suggesting a promising application potential in tissue regeneration.

Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel

“…Wet hydrogels have the advantage of easy spreadability, unlike dried hydrogels, films or aerogels. Although the materials mentioned may possess a longer degradation time, as reported in [ 28 ], wet hydrogels are known for their better dressing activity and stronger antibacterial activity [ 29 ].…”

An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

“…How to achieve the programmed release of different drugs through different scaffolds is an important issue. Fibers and hydrogel materials have their own unique advantages [ [34] , [35] , [36] , [37] ]. The release performance of fibrous materials as drug carriers is often affected by swelling of the fiber interface.…”

Assembly encapsulation of BSA and CCCH-ZAP in the sodium alginate/atractylodis macrocephalae system

“…The mechanism of SA/AM-ZAP formation is predicted that ZAP can integrate into SA/AM system in an assembly manner through chemical binding and intermolecular hydrogen bonds, and so that SA/AM-ZAP nanocomposites forms under the cross-linking of Ca 2+ . 39 …”