Modularity in Jasmonate Signaling for Multistress Resilience

Abstract

The plant hormone jasmonate coordinates immune and growth responses to increase plant survival in unpredictable environments. The core jasmonate signaling pathway comprises several functional modules, including a repertoire of COI1-JAZ (CORONATINE INSENSITIVE1-JASMONATE-ZIM DOMAIN) coreceptors that couple jasmonoyl-l-isoleucine perception to the degradation of JAZ repressors, JAZ-interacting transcription factors that execute physiological responses, and multiple negative feedback loops to ensure timely termination of these responses. Here, we review the jasmonate signaling pathway with an emphasis on understanding how transcriptional responses are specific, tunable, and evolvable. We explore emerging evidence that JAZ proteins integrate multiple informational cues and mediate crosstalk by propagating changes in protein-protein interaction networks. We also discuss recent insights into the evolution of jasmonate signaling and highlight how plant-associated organisms manipulate the pathway to subvert host immunity. Finally, we consider how this mechanistic foundation can accelerate the rational design of jasmonate signaling for improving crop resilience and harnessing the wellspring of specialized plant metabolites.

Mechanisms of a locally adaptive shift in allocation among growth, reproduction, and herbivore resistance in Mimulus guttatus *

“…; Howe et al. ) suggests a direct mechanism by which trade‐offs between growth, reproduction, and resistance could easily evolve. Future functional genetic studies will be needed to determine whether these genes in fact are involved in adaptive shifts between growth, reproduction, and defense underlying local adaptation in this system.…”

“…Thus, it would not be surprising if the genetic changes that underlie both QTL are in the same molecular pathway. Further, the negative antagonism between the GA and JA hormone pathways via the DELLA-JAZ signaling node (Havko et al 2016;Guo et al 2018;Howe et al 2018) suggests a direct mechanism by which trade-offs between growth, reproduction, and resistance could easily evolve. Future functional genetic studies will be needed to determine whether these genes in fact are involved in adaptive shifts between growth, reproduction, and defense underlying local adaptation in this system.…”

“…; Howe et al. ; Rasmann et al. ), but have yet to be evaluated in the evolutionary context of local adaptation.…”

“…Despite the development of multiple ecological and evolutionary hypotheses that postulate a relationship between growth, reproduction, and resistance to herbivores (Feeny 1976;Coley et al 1985;Rhoades 1979;Herms and Mattson 1992;Strauss et al 2002;Stamp 2003, Fine et al 2006Agrawal et al 2010;Cipollini et al 2014;Hahn and Maron 2016), these hypotheses do not make any predictions about the underlying molecular mechanisms that mediate these relationships. The genetic mechanisms responsible for trade-offs among growth, reproduction, and resistance are just beginning to be elucidated in model systems (Lorenzo et al 2004;Yang et al 2012;Kerwin et al 2015;Campos et al 2016;Havko et al 2016;Major et al 2017;Howe et al 2018;Rasmann et al 2018), but have yet to be evaluated in the evolutionary context of local adaptation.…”

Plants make galls to accommodate foreigners: some are friends, most are foes

“…Auxin, cytokinin and gibberellin have received the most attention (Yamaguchi et al, 2012;Mitchum et al, 2013;Davi ere & Achard, 2017;Tooker & Helms, 2014;Gohlke & Deeken, 2014), but brassinosteroids and strigolactones may also be important. Canonical stress hormonessalicylic acid, jasmonate, ethylene, and abscisic acidare pivotal in antagonistic plant interactions (Howe et al, 2018) but are not talked about as much when it comes to plant galls. It seems possible that this binary view of hormone functioneither for growth or immunitymay prove overly simplistic (Robert-Seilaniantz et al, 2011;Vanstraelen & Benkov a, 2012;Pieterse et al, 2012).…”