Modl-25. Analysis of Tumor Cell Heterogeneity in a Human Neural Progenitor-Based Model of Glioblastoma Reveals Neurodevelopmental Programs and Cytoskeletal Dynamics
Abstract:Glioblastoma (GBM) is the most common primary malignant neoplasm with poor survival despite treatment. Developing effective therapies remains challenging due to intratumoral heterogeneity, which drives therapeutic resistance and recurrence. To understand how genetic events alter the epigenome to enhance clonal fitness, we developed an isogenic human neural progenitor cell (NPC)-based model of the proneural (PRO) GBM subtype. We introduced TERT promoter (TERTp) C228T and gain-of-function TP53 R248Q mutations in… Show more
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