Modifying the crystallization of amorphous magnesium-calcium phosphate nanoparticles with proteins from Moringa oleifera seeds

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

“…Recently, the plant extracts were used to modify the amorphous/crystallization status of Ca and P the matter which opens the way for its use in drug delivery and nutraceutical applications [238]. Additionally, MO regulates the Ca levels in mitochondria enabling its ability to prevent mitochondrial dysfunction increasing the potentiality of mitochondrial membranes [105].…”

Biodegradable magnesium phosphates in biomedical applications

“…56 Beside, proteins that extracted from Moringa oleifera seeds not only enhanced the lifetime of the amorphous phase, which markedly delayed the transition of AMCP from amorphous to crystalline phosphate in a concentration-dependent fashion, but also influenced the type and amount of crystalline material formed. 57 In another case, Li et al reported the preparation of inorganic-organic AMCP/polyacrylic acid (PAA) hybrid NPs (B24.0 AE 4.8 nm) using a biomineralization strategy through the chelation of PAA molecules with cations in AMCP clusters (B2.1 AE 0.5 nm). The AMCP/PAA hybrid NPs exhibited good stability and pH-responsive dissolution characteristics, which could be efficiently digested under weak acidic conditions (pH 5.0-5.5).…”