Modified vaginal dilation rat model for postpartum stress urinary incontinence

Huang, Jian; Cheng, Mingjun; Ding, Yan; Li-mei, Chen; Hua, Keqin

doi:10.1111/j.1447-0756.2012.01959.x

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…Nevertheless, as vaginal balloon tamponade methods are increasingly used to control haemorrhage from severe vaginal lacerations or to prevent haematoma formation, we need to be aware of stress incontinence as a possible complication. Fortunately, as in the rat model study [16], the stress incontinence symptoms in our patient also gradually improved with time.…”

Section: Discussionsupporting

confidence: 57%

“…As far as we are aware, there are no other case reports of stress incontinence as a complication after the use of vaginal balloon tamponade as in our patient. Prolonged vaginal balloon dilation was shown to cause stress incontinence, urodynamic changes and histological abnormalities in the urethra including reduced collagen content, fragmented elastic fibers, as well as sparsely arranged and shortened striated muscle fibers in the rat model [16,17]. However, the degree of pelvic floor distension that would lead to such anatomical damage remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

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Use of balloon tamponade in management of vaginal laceration and its possible complication of urinary stress incontinence: a case report

Kong

2020

BMC Pregnancy Childbirth

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Background: Postpartum haemorrhage from vaginal lacerations can occasionally be refractory to suturing and vaginal packing. Bakri uterine balloon has been widely adopted to stop uterine bleeding, but its use to stop bleeding in vaginal lacerations and its possible complications have seldom been reported. Case presentation: We report a patient who had vacuum delivery for fetal distress and subsequently had postpartum hemorrhage due to previous caesarean uterine scar rupture and multiple vaginal lacerations. The severe bleeding persisted despite total abdominal hysterectomy, pelvic embolization and vaginal gauze packing, but was finally controlled by a Bakri balloon tamponade inserted into the vagina. The patient suffered from severe stress incontinence after delivery. The possible use of balloon tamponade in vaginal lacerations and the different types of vaginal balloons that are available in the market for this purpose are reviewed. The possible causes leading to stress incontinence is reported to alert the obstetrician that such management is not free of complications. Conclusion: The use of Bakri balloon can help to control bleeding in severe vaginal lacerations that are unresponsive to traditional vaginal gauze packing. Further studies are needed to evaluate the risks of stress incontinence as a possible complication of vaginal balloon tamponade.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Use of balloon tamponade in management of vaginal laceration and its possible complication of urinary stress incontinence: a case report

Kong

2020

BMC Pregnancy Childbirth

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“…In prior studies in control rats, mean LPP using transurethral catheterization was 35-50 cmH 2 O 10,12,23 . In a study that tested LPP with a suprapubic catheter in normal rats, mean LPP was within that range at 44.3 cmH 2 O 24 .…”

Section: Discussionmentioning

confidence: 93%

“…These two outcomes together best represent the most direct method of determining urethral function in animal models.Placement of a bladder catheter is necessary to measure bladder pressure during filling, voiding and LPP testing. Both suprapubic and transurethral catheters have been utilized in rats for LPP and EUS EMG testing [8][9][10] ; however, no head-to-head comparison has been done. Clinically, larger caliber transurethral cystometry catheters can increase LPP and prevent leakage of urine during urodynamic testing 11 , likely due to a partial urethral obstruction and/or irritation or disturbance of the integrity of the mucosal seal 12 .…”

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confidence: 99%

Transurethral versus suprapubic catheterization to test urethral function in rats

Janssen

Deng

Majerus

et al. 2021

Sci Rep

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Transurethral and suprapubic catheterization have both been used to test urethral function in rats; however, it is unknown whether these methods affect urethral function or if the order of catheterization affects the results. The aim of this cross-over designed experiment was to compare the effects of catheterization methods and order on leak point pressure (LPP) testing. LPP and simultaneous external urethral sphincter electromyography (EUS EMG) were recorded in anesthetized female virgin Sprague-Dawley rats in a cross-over design to test the effects of transurethral and suprapubic catheterization. There was no significant difference in peak bladder pressure during LPP testing whether measured with a transurethral or suprapubic catheter. There was no significant difference in peak bladder pressure between the first and second catheter insertions. However, peak EMG firing rate, as well as peak EMG amplitude and EMG amplitude difference between peak and baseline were significantly higher after the first catheter insertion compared to the second insertion, regardless of the catheter method. Our results suggest that route of catheterization does not alter urethral function, e.g. create a functional partial outlet obstruction. Either catheterization method could be used for LPP and/or EUS EMG testing in rats.

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“…After 4 weeks, the rate of stress incontinence was 20.8% (19/48 mouse). Huang et al elongated the dilatation interval to 8 h and achieved to 72.5% (29/40 mouse) [ 76 ].…”

Section: Study Animalsmentioning

confidence: 99%

Review of Animal Models to Study Urinary Bladder Function

Shen

Chen

et al. 2021

Biology

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The urinary bladder (UB) serves as a storage and elimination organ for urine. UB dysfunction can cause multiple symptoms of failure to store urine or empty the bladder, e.g., incontinence, frequent urination, and urinary retention. Treatment of these symptoms requires knowledge on bladder function, which involves physiology, pathology, and even psychology. There is no ideal animal model for the study of UB function to understand and treat associated disorders, as the complexity in humans differs from that of other species. However, several animal models are available to study a variety of other bladder disorders. Such models include animals from rodents to nonhuman primates, such as mice, rats, rabbits, felines, canines, pigs, and mini pigs. For incontinence, vaginal distention might mimic birth trauma and can be measured based on leak point pressure. Using peripheral and central models, inflammation, bladder outlet obstruction, and genetic models facilitated the study of overactive bladder. However, the larger the animal model, the more difficult the study is, due to the associated animal ethics issues, laboratory facility, and budget. This review aims at facilitating adapted animal models to study bladder function according to facility, priority, and disease.

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Modified vaginal dilation rat model for postpartum stress urinary incontinence

Cited by 10 publications

References 24 publications

Use of balloon tamponade in management of vaginal laceration and its possible complication of urinary stress incontinence: a case report

Use of balloon tamponade in management of vaginal laceration and its possible complication of urinary stress incontinence: a case report

Transurethral versus suprapubic catheterization to test urethral function in rats

Review of Animal Models to Study Urinary Bladder Function

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