Modified resin infiltration of non-, micro- and cavitated proximal caries lesions in vitro

Askar, Haitham; Schwendicke, Falk; Lausch, Julian; Meyer-Lueckel, Hendrik; Paris, Sebastian

doi:10.1016/j.jdent.2018.03.010

Cited by 13 publications

(27 citation statements)

References 20 publications

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“…While this was considered comparable to our previous study [32], AgNP concentrated outside the lesion, and enriched in locations of tiny surface disintegration. The latter effect was comparable to recent observations using the same infiltrant resin along with prepolymerized methacrylate-based nanofillers [109], and clearly revealed a segregation of the components during the infiltration process (see Fig 3). This targeted accumulation is considered advantageous; it should be borne in mind that a reduced biofilm mass would render the contact-killing mechanisms of nanosilver particles effective.…”

Section: Discussionsupporting

confidence: 91%

Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin

Kielbassa¹,

Leimer²,

Hartmann³

et al. 2020

PLoS ONE

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This ex vivo proof-of-concept study aimed to investigate the effect of nanosilver particles (AgNP) added to a conventional infiltrant resin (Icon) on external penetration into natural proximal enamel caries exceeding into dentin after internal tunnel preparation and internal infiltration. Carious lesions (ICDAS codes 2/3) of extracted human (pre-)molars revealing proximal caries radiographically exceeding into dentin (E2/D1 lesions) were preselected. Then, 48 of those specimens showing demineralized areas transcending the enamel-dentin border as assessed by means of near-infrared light transillumination (DIAGNOcam) were deproteinized (NaOCl, 5%). Using an internal tunnel approach, occlusal cavities central to the marginal ridge were prepared. Excavation of carious dentin, total etch procedure (H 3 PO 4 , 40%), and internal resin infiltration (FITC-labeled) followed, along with final restorations (flowable composite resin). Outer lesion surfaces were etched (HCl, 15%) prior to external infiltration (RITC-labeled). Group 1 (control; n = 24) used non-modified infiltrant, while an infiltrant/ AgNP mixture (20 nm; 5.5 wt%) was used with experimental Group 2 (n = 24). Non-infiltrated pores of cut lesions were stained (Berberine), and specimens were analyzed using confocal laser scanning microscopy. Compared to the non-filled infiltrant, incorporation of AgNP had no effect on the resin's external penetration. Between the groups, no significant differences regarding internal or external infiltration could be detected, and non-infiltrated lesion areas did not differ significantly (p>0.109; t-test). The internal tunnel preparation in combination with both an internal resin infiltration and an additional external infiltration approach using a nanosilver-modified infiltrant resin leads to increased infiltrated lesion areas, thus occluding and adhesively stabilizing the porous volume of the demineralized enamel. While exerting antimicrobial effects by the nanosilver particles, this approach should have the potential as a viable treatment alternative for proximal lesions extending into dentin, thus avoiding the sacrifice of sound enamel, postponing the frequently inevitable restoration/re-restoration cycle of conventional proximal caries treatment, and improving dental health.

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Section: Discussionsupporting

confidence: 91%

Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin

Kielbassa¹,

Leimer²,

Hartmann³

et al. 2020

PLoS ONE

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“…In this systematic review, twenty-three articles reported information about microhardness , ten evaluated surface roughness, [27,31,37,47,[49][50][51][52][53][54], sixteen assessed the penetration depth [40,46,50,[55][56][57][58][59][60][61][62][63][64][65][66][67] and eight explored shear bond strength after resin infiltration [32,52,[68][69][70][71][72][73].…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Overall, twelve studies included bovine teeth (n per group = 803) while twenty-five studies included human teeth (n per group = 865). Nine studies reported data without specimen demineralization previously to resin infiltration [47,54,55,57,59,[61][62][63][64]74] and thirty-nine articles included the demineralization process before the infiltrative resin [21,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][48][49][50][51][52][53]56,58,60,[65][66][67][69][70][71][72][73]. The demineralization process consists of emerging the teeth in a demineralization solution, with pH between 4 and 5 for a period of time that ranges from 1 min to 1200 h, to simulate the formation of WSLs (Table…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Effect of Resin Infiltration on Enamel: A Systematic Review and Meta-Analysis

Soveral

Machado

Botelho

et al. 2021

JFB

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Subsurface enamel demineralization beneath an intact surface layer or white spots lesions (WSL) can and should be treated with non-invasive procedures to impede the development of a cavitated lesion. We aim to analyze if infiltrative resin improves enamel roughness, microhardness, shear bond strength, and penetration depth. MEDLINE [via Pubmed], Cochrane Central Register of Controlled Trials, Embase, Web of Science, Scholar, and LILACS were searched until May 2021. Methodological quality was assessed using the Joanna Briggs Institute Clinical Appraisal Checklist for Experimental Studies. Pairwise ratio of means (ROM) meta-analyses were carried out to compare the enamel properties after treatment with infiltrative resin on sound enamel and WSLs. From a total of 1604 articles, 48 studies were included. Enamel surface roughness decreased 35% in sound enamel (95%CI: 0.49–0.85, I2 = 98.2%) and 54% in WSLs (95%CI: 0.29–0.74, I2 = 98.5%). Microhardness reduced 24% in sound enamel (95%CI: 0.73–0.80, I2 = 99.1%) and increased by 68% in WSLs (95%CI: 1.51; 1.86, I2 = 99.8%). Shear bond strength reduced of 25% in sound enamel (95%CI: 0.60; 0.95, I2 = 96.9%) and increased by 89% in WSLs (95%CI: 1.28–2.79, I2 = 99.8%). Penetration depth was 65.39% of the WSLs (95%CI: 56.11–74.66, I2 = 100%). Infiltrative resins effectively promote evident changes in enamel properties in sound and WSLs. Future studies with long-term follow-ups are necessary to corroborate these results from experimental studies.

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“…The confocal laser microscopy (CSLM), a microscopic observation technique that presents excellent results in different scientific fields like medicine, biology, materials, geology, and more, is a useful tool to provide information about the penetration depth of infiltrant resin in demineralized enamel (2,5,10,12,13). Its success is due to the advantages it has over the traditional optical technology (like image sharpness and contrast, better resolution, and others) (12,13).…”

Section: Infiltrant Resin In White Spot Lesionsmentioning

confidence: 99%

“…The white stains are signs of a demineralization process that could evolve into a dentin cavity lesion. These stains occur when the pathogenic bacteria penetrate the base of the enamel and produce organic acids, eliminating calcium and phosphate ions from the enamel, which may be remineralized or not (2).…”

Section: Introductionmentioning

confidence: 99%

Effect of Conditioning Protocols and Ultrasonic Application of an Infiltrant Resin in White Spot Lesions

et al. 2019

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The aim of this study was to evaluate different conditioning protocols and sonic/ ultrasonic application of an infiltrant resin (IR) in artificial white spot lesions (AWSL). the V/L surfaces of 48 molars were induced to an AWSL and divided in 6 groups, according to the conditioning protocols and application technique: 15% hydrochloric acid (HA) + manual application of the IR; HA + 37% phosphoric acid (PA) + manual application of the IR; HA + ultrasonic application (U) of the IR; HA + sonic application (S) of the IR; PA+HA+S; and PA+HA+U. For the Penetration Depth (PD), the crowns were etched with HA for 120s. The IR Icon® (DMG) was applied according to the manufacturer`s instructions. The crowns were dye penetrated (0.1% red fluorophore rhodamine B isothiocyanate for 12h) and bleached with 30% hydrogen peroxide for 12 h. The discs were immersed in a 50% ethanol solution, containing 100 µM of sodium fluorescein. The PD (in µm) was measured using confocal laser scanning microscopy (20x). The bond strength (BS) was performed by michoshear test (0.5 mm/min). Data were submitted to 2-way ANOVA and Tukey (α=0.05). For BS, the interaction was not significant (p>0.05). For PD, the main factors were significant (application -p<0.001; conditioning technique -p=0.003). The ultrasonic application showed the highest PD values. PA+HA presented higher results than HA. The sonic/ultrasonic applications and the use of phosphoric acid prior to hydrochloric acid improved PD of the infiltrant resin. Conditioning protocols or application techniques did not influence BS values.

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Modified resin infiltration of non-, micro- and cavitated proximal caries lesions in vitro

Cited by 13 publications

References 20 publications

Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin

Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin

Effect of Resin Infiltration on Enamel: A Systematic Review and Meta-Analysis

Effect of Conditioning Protocols and Ultrasonic Application of an Infiltrant Resin in White Spot Lesions

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