Modified Natural Zeolites—Functional Characterization and Biomedical Application

Milić, Jela; Daković, Aleksandra; Krajišnik, Danina; Rottinghaus, George E.

doi:10.1002/9781118774205.ch10

Cited by 6 publications

(5 citation statements)

References 79 publications

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“…Over the past decades, there has been increased interest in applying natural zeolites as active ingredients in human and veterinary supplements. They are used either in oral supplements for endogenous well-being or in topical application for skin discomfort (Rodríguez-Fuentes et al 1997, 2006; Andronikashvili et al 2009; Colella 2011; Milić et al 2014; Cerri et al 2016; Dathe 2016), due to their excellent binding capacities for toxins and other harmful substances.…”

Section: Introductionmentioning

confidence: 99%

Histamine-binding capacities of different natural zeolites: a comparative study

Selvam

Schwieger

Dathe³

2018

Environ Geochem Health

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Two different natural zeolites from Cuba and Mexico, which are already being used as contemporaneous drugs or dietary supplements in Germany and Mexico, respectively, are applied in a comparative study of their histamine-binding capacities as a function of their particle sizes. The zeolites are characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM) and N-sorption measurements (BET surface areas). The Cuban zeolite contains clinoptilolite and mordenite as major phases (78% zeolite), whereas the Mexican one contains only clinoptilolite (65% zeolite). Both zeolites are apparently free from fibrous materials according to SEM. Both zeolites adsorb significant amount of histamine under the experimental conditions. Nevertheless, the results showed that the histamine-binding capacity of the Cuban zeolite is higher than the Mexican one and the smaller the particle size of zeolite, the higher the histamine-binding capacity. This difference could be due to the variation in their mineralogical compositions resulting in varied BET surface areas. Thus, the high histamine-binding capacities of Cuban zeolites seem to be due at least partly to the presence of the large-pore zeolite mordenite, providing high total pore volumes, which will be discussed in detail. For the first time, we have shown that the mineralogical compositions of natural zeolites and their particle sizes play a key role in binding histamine, which is one of the most important regulators in human physiology.

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Section: Introductionmentioning

confidence: 99%

Histamine-binding capacities of different natural zeolites: a comparative study

Selvam

Schwieger

Dathe³

2018

Environ Geochem Health

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“…Sedangkan klinoptilolit berbentuk kubus atau balok (Ashutosh 2014), apabila zeolit terlihat berserat maka dapat dimungkinkan adanya fase mineral non zeolit yang tergabung dalam sampel. Pada Gambar 1, hasil analisis SEM zeolit alam asal Lampung, dari hasil perbesaraan 5000x dan 20000x terlihat bahwa zeolit alam asal Lampung tidak berbentuk jarum, sebagaimana yang ditunjukkan dalam literatur (Milić et al 2014), sampel tersebut berjenis Cli-Heu (Clinoptilolite-Heulandite), jenis zeolite tersebut tidak bisa dibedakan hanya dari foto SEM tetapi perlu dilakukan perhitungan rasio Si/Al (Milić et al 2014). Hal tersebut dapat dikonfirmasi juga dengan dilengkapi dari data difraktogram pada analisis XRD.…”

Section: Hasil Dan Pembahasanunclassified

Karakterisasi Dan Pemurnian Zeolit Alam Lampung Sebagai Kandidat Antidotum Keracunan Timbal

et al. 2017

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Indonesia memiliki kelimpahan zeolit yang berpotensi dapat dikembangkan sebagai zeolit yang berderajat farmasi. Penelitian ini bertujuan untuk mendapatkan zeolit olahan dengan karakteristik yang cocok sebagai bahan baku farmasi. Zeolit alam diproses dengan cara pencucian menggunakan masing-masing larutan HCl, aquabidest, dan EDTA lalu diikuti dengan pemanasan pada 350 °C. Sebelum dan sesudah pengolahan sampel zeolit dikarakterisasi menggunakan berbagai metode instrumental. Selanjutnya, zeolit olahan diuji kemampuannya untuk menjerap parasetamol dan timbal. Hasil analisis menunjukkan bahwa komposisi sampel zeolit > 91% berjenis klinoptilolit dengan kandungan utama unsur Si, Al dan K. Setelah pencucian dengan larutan HCl 1 M, EDTA 0,1 M dan aquabidest, kadar As dalam masing-masing sampel zeolit 4,12 ± 0,75 ppm, < 0,1 ppm dan 11,8 ± 0,56 ppm dan kadar Pb untuk seluruh sampel < 1 ppm, sedangkan Cd dari semua sampel < 1 ppm. Tidak ada perubahan struktur dalam sampel zeolit yang teramati setelah proses pencucian dan pemanasan. Zeolit yang dicuci dengan larutan EDTA mampu menjerap Pb dalam cairan lambung buatan tanpa pepsin secara efektif dengan penurunan kadar hingga 89% namun tidak mampu menjerap parasetamol secara efektif. Disimpulkan bahwa hasil proses zeolit menunjukkan karakteristik yang cocok sebagai kandidat bahan baku farmasi. Zeolit yang diberi perlakuan dengan EDTA mampu menjerap Pb secara efektif sehingga berpeluang digunakan sebagai antidot lokal dalam kasus keracunan Pb akut.Kata kunci: zeolit, klinoptilolit, logam berat. CHARACTERIZATION AND PURIFICATION OF NATURAL LAMPUNG ZEOLITE AS A CANDIDATE OF ANTIDOTE OF LEAD INTOXICATIONABSTRACTIndonesia has the abundance potential of zeolites having possibility to be developed as pharmaceutical grade zeolites. This research aimed to obtain processed zeolite showing suitable characteristics as pharmaceutical ingredient. Natural zeolite was processed by means of washing using dilute HCl, aquabidest and EDTA solutions, respectively and subsequently followed by heating at 350 oC. Prior and after processing, the zeolite samples were characterized using various instrumental methods. Furthermore, the processed zeolite was tested for its ability to adsorb paracetamol and lead. The analysis results confirmed that the composition of zeolite samples were > 91% of clinoptilolite mainly composed of Si, Al and K. After washing with 1 M HCl, 0.1 M EDTA and aquabidest, the level of As in each of zeolite samples were 4.12 ± 0.75 ppm, < 0.1 ppm and 11.8 ± 0.56 ppm and those of Pb were all < 1 ppm, while those of Cd from all samples were < 1 ppm, respectively. No structural changes in zeolite samples were observed after washing and heating treatment. EDTA treated zeolite was able to adsorb Pb in artificial gastric fluid without pepsin effectively up to 89% reduction but failed to adsorb paracetamol effectively. It was concluded that processed natural zeolite was suitable as a pharmaceutical ingredient. EDTA-treated zeolite was able to adsorb Pb effectively and hence could be possibly applied as local antidote in the case of acute Pb intoxication.Keywords: zeolite, clinoptilolite, heavy metals.

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“…Njihova primena zasnovana je na poroznoj strukturi, velikoj specifičnoj površini, visokom adsorpcionom kapacitetu, sposobnosti bubrenja u vodi i tiksotropnim osobinama njihovih vodenih disperzija, mogućnosti jonske izmene kao i specifičnim površinskim karakteristikama koje ih čine pogodnim za naknadnu modifikaciju (funkcionalizaciju) u cilju povećanja kapaciteta vezivanja i/ili postizanja modifikovanog oslobađanja lekovite supstance (43)(44)(45)(46)(47). Pored glina, kao tradicionalnih farmaceutskih ekscipijenasa, aktuelna su ispitivanja mogućnosti primene i drugih predstavnika poroznih neorganskih materijala prirodnog porekla, poput zeolita (48,49) i dijatomita (50,51) kao potencijalnih farmaceutskih ekscipijenasa/funkcionalizovanih nosača za modifikovano oslobađanje lekovitih supstanci.…”

Section: Funkcionalnost Ekscipijenasa U Mikro-i Nanonosačima Lekovitiunclassified

Excipients functionality: Importance and compendial status

Milić¹,

Čalija²,

Krajišnik³

2016

Arh farmaciju

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Saznanje da pomoćne supstance/ekscipijensi mogu značajno uticati na kvalitet, bezbednost i efikasnost lekova u potpunosti je izmenilo tradicionalno shvatanje ekscipijenasa kao jednostavnih, inertnih i neaktivnih sastojaka farmaceutskog oblika leka. Da bi se izradio/proizveo lek prihvatljivog kvaliteta neophodno je, pored ostalog, identifikovati one karakteristike ekscipijenasa koje su od značaja za njihovu ulogu u farmaceutskom preparatu/proizvodu, ispitati na koji način i u kojoj meri te karakteristike utiču na konkretnu ulogu, a potom definisati opsege prihvatljivih vrednosti tih karakteristika. Ove karakteristike ekscipijenasa nazivaju se funkcionalnim karakteristikama, a način na koji, i stepen u kome ekscipijensi ostvaruju namenjenu ulogu u konačnoj formulaciji, definišu se kao njihova funkcionalnost. Funkcionalnost ekscipijenasa zavisi i od konačne formulacije leka i postupka njegove izrade/proizvodnje, te se zbog toga ne može generalizovati, nego se može posmatrati samo u odnosu na konkretan lek, određenog sastava, koji se dobija određenim proizvodnim procesom/postupkom izrade.U ovom radu biće reči o definiciji, značaju i farmakopejskom statusu funkcionalnosti i funkcionalnih karakteristika ekscipijenasa, te o funkcionalnim karakteristikama kao kritičnim svojstvima kvaliteta leka, sa stanovišta QbD pristupa razvoju leka.

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Modified Natural Zeolites—Functional Characterization and Biomedical Application

Cited by 6 publications

References 79 publications

Histamine-binding capacities of different natural zeolites: a comparative study

Histamine-binding capacities of different natural zeolites: a comparative study

Karakterisasi Dan Pemurnian Zeolit Alam Lampung Sebagai Kandidat Antidotum Keracunan Timbal

Excipients functionality: Importance and compendial status

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