Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration

Chen, Jiaqing; Yang, Jun; Wang, Li; Zhang, Xuewei; Heng, Boon Chin; Wang, Dong‐An; Ge, Zigang

doi:10.1016/j.bioactmat.2020.11.020

Cited by 136 publications

(125 citation statements)

References 59 publications

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“…In our previous study, we used a HAMA hydrogel to induce chondrogenic differentiation of stem cells in vitro and significantly improved the cartilage regeneration ability in a rat osteochondral defect model. The cartilage defect was almost completely resolved in 4 weeks [ 19 ]. These findings indicate that we replicated the physiological structure of natural cartilage.…”

Section: Discussionmentioning

confidence: 99%

Dual Delivery of TGF-β3 and Ghrelin in Microsphere/Hydrogel Systems for Cartilage Regeneration

2021

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Articular cartilage (AC) damage is quite common, but due to AC’s poor self-healing ability, the damage can easily develop into osteoarthritis (OA). To solve this problem, we developed a microsphere/hydrogel system that provides two growth factors that promote cartilage repair: transforming growth factor-β3 (TGF-β3) to enhance cartilage tissue formation and ghrelin synergy TGF-β to significantly enhance the chondrogenic differentiation. The hydrogel and microspheres were characterized in vitro, and the biocompatibility of the system was verified. Double emulsion solvent extraction technology (w/o/w) is used to encapsulate TGF-β3 and ghrelin into microspheres, and these microspheres are encapsulated in a hydrogel to continuously release TGF-β3 and ghrelin. According to the chondrogenic differentiation ability of mesenchymal stem cells (MSCs) in vitro, the concentrations of the two growth factors were optimized to promote cartilage regeneration.

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Section: Discussionmentioning

confidence: 99%

Dual Delivery of TGF-β3 and Ghrelin in Microsphere/Hydrogel Systems for Cartilage Regeneration

2021

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“… Polymer Type Polymer Name Chemical Structure Existence in Osteochondral Tissue and/or Origin Advantages Limitations References Natural polymers: Polysaccharide Hyaluronic acid (HA) Yes. The most abundant GAG in native cartilage ECM component (vital in the structural and functional maintenance of cartilage: the morphogenesis and proliferation of chondrocytes, formation of proteoglycans and collagen II, water adsorption and retention, lubrication and compression bearing, immune system modulation), easy to be functionalized Poor mechanical properties, rapid degradation, week cell adhesion [ [84] , [85] , [86] , [87] ] Chondroitin sulfate Yes. A sulfated GAG ubiquitous in native cartilage ECM ECM component (beneficial in reducing pain and functional limitation associated with knee osteoarthritis, anti-inflammatory activity, role in cell recognition and signaling), easy to be functionalized Poor mechanical properties, rapid degradation [ [88] , [89] , [90] , [91] , [92] ] Alginate No.…”

Section: Strategies Of the Scaffolds For Cartilage And Osteochondral Tissue Engineeringmentioning

confidence: 99%

“…As the most abundant GAG in native cartilage, HA plays a pivotal role in the structural and functional maintenance of cartilage. To overcome its disadvantages for cartilage and osteochondral regeneration like inadequate mechanical properties and degradability, much effort has been taken through the incorporation of additional polymer networks [ 149 ] or by chemical modifications at the hydroxyl and carboxyl functional groups using methacrylate [ 86 ], thiol [ 150 ], enzyme [ 151 ] and amino acid [ 152 ]. Chondroitin sulfate is similar with hyaluronan in fundamental structural and biological processes.…”

Section: Strategies Of the Scaffolds For Cartilage And Osteochondral Tissue Engineeringmentioning

confidence: 99%

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Wei

Dai

2021

Bioactive Materials

182

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In spite of the considerable achievements in the field of regenerative medicine in the past several decades, osteochondral defect regeneration remains a challenging issue among diseases in the musculoskeletal system because of the spatial complexity of osteochondral units in composition, structure and functions. In order to repair the hierarchical tissue involving different layers of articular cartilage, cartilage-bone interface and subchondral bone, traditional clinical treatments including palliative and reparative methods have showed certain improvement in pain relief and defect filling. It is the development of tissue engineering that has provided more promising results in regenerating neo-tissues with comparable compositional, structural and functional characteristics to the native osteochondral tissues. Here in this review, some basic knowledge of the osteochondral units including the anatomical structure and composition, the defect classification and clinical treatments will be first introduced. Then we will highlight the recent progress in osteochondral tissue engineering from perspectives of scaffold design, cell encapsulation and signaling factor incorporation including bioreactor application. Clinical products for osteochondral defect repair will be analyzed and summarized later. Moreover, we will discuss the current obstacles and future directions to regenerate the damaged osteochondral tissues.

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“…One of the most extensive modifications of HA is the formation of hyaluronic acid methacryloyl (HAMA) by HA and methacrylic anhydride under alkaline conditions [49]. Chen et al [50] modified HA with aldehyde and methacrylic acid to create an injectable adhesive hyaluronic acid hydrogel (AHAMA). The aldehyde group of the hydrogel and the amino group of the cartilage tissue were closely bonded to one body through the Schiff base reaction, promoting the combination of new cartilage and natural cartilage and significantly promoting cartilage regeneration.…”

Section: Types Of Hydrogelsmentioning

confidence: 99%

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

Yan

Wang

Xiang

et al. 2021

BioMed Research International

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Intervertebral disc degeneration (IDD) is caused by genetics, aging, and environmental factors and is one of the leading causes of low back pain. The treatment of IDD presents many challenges. Hydrogels are biomaterials that possess properties similar to those of the natural extracellular matrix and have significant potential in the field of regenerative medicine. Hydrogels with various functional qualities have recently been used to repair and regenerate diseased intervertebral discs. Here, we review the mechanisms of intervertebral disc homeostasis and degeneration and then discuss the applications of hydrogel-mediated repair and intervertebral disc regeneration. The classification of artificial hydrogels and natural hydrogels is then briefly introduced, followed by an update on the development of functional hydrogels, which include noncellular therapeutic hydrogels, cellular therapeutic hydrogel scaffolds, responsive hydrogels, and multifunctional hydrogels. The challenges faced and future developments of the hydrogels used in IDD are discussed as they further promote their clinical translation.

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Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration

Cited by 136 publications

References 59 publications

Dual Delivery of TGF-β3 and Ghrelin in Microsphere/Hydrogel Systems for Cartilage Regeneration

Dual Delivery of TGF-β3 and Ghrelin in Microsphere/Hydrogel Systems for Cartilage Regeneration

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

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