Modified glassy carbon electrodes based on carbon nanostructures for ultrasensitive electrochemical determination of furazolidone

Shahrokhian, Saeed; Naderi, Leila; Ghalkhani, Masoumeh

doi:10.1016/j.msec.2016.01.025

Cited by 76 publications

(29 citation statements)

References 46 publications

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“…Additionally, our analytical parameters are comparable to or even lower than those of the previously reported electrochemical platforms for the FZD detection (Table ). − The improved electrocatalytic activity of the VC/g-CN NSs-modified electrode is associated with several reasons. The nanocomposite with large surface area, synergistic interface, strong electronic interaction, and more active sites can allow an adequate electrode/electrolyte interaction to provide the enhanced electrocatalytic performance toward the detection of FZD.…”

Section: Resultsmentioning

confidence: 99%

Vanadium Carbide-Entrapped Graphitic Carbon Nitride Nanocomposites: Synthesis and Electrochemical Platforms for Accurate Detection of Furazolidone

Kokulnathan

Wang

2020

ACS Appl. Nano Mater.

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Recently, two-dimensional nanomaterials have received great attention in the field of electrochemical applications because of their outstanding physicochemical properties. In this research, we developed vanadium carbide entrapped on graphitic carbon nitride nanosheets (VC/g-CN NSs) as a highly efficient electrocatalyst for the determination of furazolidone (FZD) in biological samples. The VC/g-CN NSs nanocomposite was systematically characterized by various analytical and spectroscopic techniques. The electrochemical performance of the VC/g-CN NSs-modified glassy carbon electrode (GCE) for the FZD detection was studied by the cyclic voltammetry and amperometric methods. On the one hand, the fabricated electrode offers numerous active sites with the large electron-transfer rate and the rapid mass transport ability to enhance the electrochemical activity toward the FZD detection. Under the optimization conditions, the VC/g-CN NSs modified electrode showed a wide detection range (0.004−141 μM), very low detection limit (0.5 nM), excellent selectivity, and reproducibility. Compared to the previous studies, the fabricated VC/g-CN NSs/GCE achieves the lowest limit of detection and the widest linear rangetoward the FZD detection. Furthermore, the fabricated sensor was successfully applied to determine FZD in the biological samples with satisfactory results.

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Section: Resultsmentioning

confidence: 99%

Vanadium Carbide-Entrapped Graphitic Carbon Nitride Nanocomposites: Synthesis and Electrochemical Platforms for Accurate Detection of Furazolidone

Kokulnathan

Wang

2020

ACS Appl. Nano Mater.

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“…Further, the slope value of log I p versus log ν, designates the electrode process found here is the mixed adsorption-diffusion controlled process ( Figure 7B). 48,49 This type of process may be associated to the adsorption of the analyte moiety i.e. FFA at the electrode base and then their diffusion through the bibulous sensing surface.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Shetti

Nayak

Malode

et al. 2016

J. Electrochem. Soc.

100

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In the current research, ruthenium stood a conspicuous dopant for TiO 2 nanoparticles, to enhance its catalytic activity. The characterization of synthesized nanoparticles was accomplished by utilizing XRD, SEM, EDX and TEM analysis. The sensing surface morphology was studied by AFM analysis. Further, we established the electrochemical behavior and detection of flufenamic acid (FFA) by utilizing ruthenium doped TiO 2 nanoparticles modified carbon paste electrode (Ru-TiO 2 /CPE) at pH 6.0 by employing different voltammetric techniques. Modification enhances the electro-oxidation of flufenamic acid with increased current intensity. The influence of parameters like scan rate, pH, accumulation time, amount of the modifier and concentration on the peak current of the drug were studied. The effect of FFA concentration variation was studied using square wave voltammetric (SWV) technique and got lowest detection limit compared to reported techniques. The fabricated sensor was employed for the determination of flufenamic acid in biological samples. Flufenamic acid (FFA), N-(α,α,α-trifluoro-m-tolyl) an anthranilic acid derivative (Scheme 1), is an effective analgesic, an antiinflammatory and antipyretic agent used for the relief of pain and inflammation associated with musculoskeletal and joint disorders, peri-articular and soft tissue disorders, antirheumatic therapy.1,2 Monitoring of therapeutic drug habitually necessitates its detection in biological fluids.Many analytical methods based on different principles, such as spectrophotometry, 3-6 spectrofluorimetry, 5,11 fluorescence spectrometry, 7-10 flow injection analysis, 11,12 chromatography [13][14][15] have been developed for the analysis of flufenamic acid along with its derivatives. Capillary electrophoresis [16][17][18] is an alternative methodology for the separation and detection of FFA. However, these methods are well-demonstrated and broadly accepted, but they require moderately costly equipment, laborious sample pretreatment, specialized expertise, high cost and are time-consuming which make them unsuitable for routine analysis. Few voltammetric studies 5,19 were also carried out by utilizing cyclic voltammetry and adsorptive voltammetry. Though, these sensors suffer from the less sensitive, poor long-term stability, lack of surface renewability, etc.As of late, research developed, aiming at the construction and the characterization of the electrodes composed of carbonaceous materials because of their rich surface chemistry, lower background current, wider potential window, uncomplicated surface renewal and low detection limit properties. [20][21][22][23][24] The fabrication of the working electrode with nanoparticles enhances peak current, sensitivity, reproducibility. 25,26 In current science and technology, one of the crucial uniqueness is to survey and to discover the new efficient materials as electrode surface modifiers.In general, new types of sensor devices are the outcome of the synthesis and preparation of innovative modifiers. In this regard, as e...

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“…Among antibiotics, the widely used ones are those from the nitro-containing aromatic molecules. In particular, furazolidone (FZD) belongs to the family of nitrofuran derivatives, most of which are used to prevent and treat microbial infections in animal husbandry and aquaculture caused by Salmonella, Shigella, Staphylococci, and Escherichia coli . − Consumption of FZD residues through the food chain can cause several health problems such as potential mutagenic effects, decreased white blood cells, carcinogenic effects, DNA damage, inflammation of the skin, stomach cramps, teratogenic effects, and cytotoxic, mutagenic, and carcinogenic behavior. − It could increase growth of mammary tumor incidence of Rattus gradually when it was fed continuously to the female Sprague–Dawley Rattus for 2 years …”

Section: Introductionmentioning

confidence: 99%

Construction of Lanthanum Vanadate/Functionalized Boron Nitride Nanocomposite: The Electrochemical Sensor for Monitoring of Furazolidone

Kokulnathan

Almutairi

Chen

et al. 2021

ACS Sustainable Chem. Eng.

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The electrochemical sensor has received considerable attention because of the future on-time monitoring technologies. To meet the requirements of on-time monitoring applications, it is of prodigious importance to discover new catalysts for the electrochemical sensor that have good conductivity and physicochemical properties. The novelty of this work is the successful synthesis of lanthanum vanadate/functionalized boron nitride (LaV/F-BN) nanocomposites and their application toward the electrochemical detection of furazolidone (FZD). The fabricated sensors containing nanocomposites of LaV/F-BN modified electrode displayed improved electrochemical sensing behavior for the detection of FZD compared to other electrodes. This electrocatalyst showed reduction potential at −0.42 V (vs Ag/AgCl2), a low detection limit (0.003 μM), acceptable selectivity, and wide linear range (0.015–300 μM) with a correlation coefficient of 0.995, which is better than the previous literature. The enhanced catalytic activity of the proposed sensor is mainly attributed to the abundant exposed active sites, high surface area, better conductivity, rapid electron transfer, synergistic effect, and functional groups. The practical utility of the LaV/F-BN based sensor was evaluated via the determination of FZD in human blood serum and urine samples.

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Modified glassy carbon electrodes based on carbon nanostructures for ultrasensitive electrochemical determination of furazolidone

Cited by 76 publications

References 46 publications

Vanadium Carbide-Entrapped Graphitic Carbon Nitride Nanocomposites: Synthesis and Electrochemical Platforms for Accurate Detection of Furazolidone

Vanadium Carbide-Entrapped Graphitic Carbon Nitride Nanocomposites: Synthesis and Electrochemical Platforms for Accurate Detection of Furazolidone

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Construction of Lanthanum Vanadate/Functionalized Boron Nitride Nanocomposite: The Electrochemical Sensor for Monitoring of Furazolidone

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Modified glassy carbon electrodes based on carbon nanostructures for ultrasensitive electrochemical determination of furazolidone

Cited by 76 publications

References 46 publications

Vanadium Carbide-Entrapped Graphitic Carbon Nitride Nanocomposites: Synthesis and Electrochemical Platforms for Accurate Detection of Furazolidone

Vanadium Carbide-Entrapped Graphitic Carbon Nitride Nanocomposites: Synthesis and Electrochemical Platforms for Accurate Detection of Furazolidone

Electrochemical Sensor Based upon Ruthenium Doped TiO2Nanoparticles for the Determination of Flufenamic Acid

Construction of Lanthanum Vanadate/Functionalized Boron Nitride Nanocomposite: The Electrochemical Sensor for Monitoring of Furazolidone

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Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid