2021
DOI: 10.3390/pharmaceutics13101537
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Abstract: Gelatin nanoparticles found numerous applications in drug delivery, bioimaging, immunotherapy, and vaccine development as well as in biotechnology and food science. Synthesis of gelatin nanoparticles is usually made by a two-step desolvation method, which, despite providing stable and homogeneous nanoparticles, has many limitations, namely complex procedure, low yields, and poor reproducibility of the first desolvation step. Herein, we present a modified one-step desolvation method, which enables the quick, si… Show more

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Cited by 15 publications
(9 citation statements)
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References 77 publications
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“…Probably, the stability of gelatin-coated nanoparticles depends on their concentration. We have already observed a similar phenomenon for nanoparticles prepared from gelatin A in our previous work [79].…”
Section: Conjugation Of 'Artificial Peroxidase' Nanoparticles With Re...supporting
confidence: 79%
“…Probably, the stability of gelatin-coated nanoparticles depends on their concentration. We have already observed a similar phenomenon for nanoparticles prepared from gelatin A in our previous work [79].…”
Section: Conjugation Of 'Artificial Peroxidase' Nanoparticles With Re...supporting
confidence: 79%
“…S5a ). Also, we studied the effect of salt (10 mM NaCl) or sugar (10% sucrose) in gel sol in the formation of nanoparticles [ 5 , 59 ]. The results showed that formation of G X was unhindered by either of the molecules further reiterating no influence on the ionic interactions between ammonium ions and TPP molecules ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Bioactive gelatin has gained significant prominence in recent years due to its application in various medical fields ranging from tissue regeneration to cancer therapy [ [1] , [2] , [3] , [4] ]. It is biodegradable, biocompatible, non-immunogenic, and approved by FDA as a safe pharmaceutical excipient; additionally, it is easily sterilizable and has a low degree of antigenicity [ 5 ]. By converting gelatin into nanoparticles, gelatin gained greater utility in medicine, especially as a drug delivery agent for a vast array of diseases.…”
Section: Introductionmentioning
confidence: 99%
“…The gelatin nanoparticles dispersion was then mixed at 10,000 g for 30 min before being rinsed through water to discard free drug adherents from the nanoparticles' extraneous surface. The lyophilized powder was then kept at room temperature in impenetrable glass containers until required 17,18 .…”
Section: Methods: Formulation Of Acyclovirmentioning
confidence: 99%