Modification of the central hypotensive effect of α-methyldopa by reserpine, imipramine and tranylcypromine

Kale, Arzum; Satoskar, R. S.

doi:10.1016/0014-2999(70)90330-4

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…These results are in agreement with the hypothesis of Henning & Rubenson (1971) that the hypotensive action of ax-methyldopa is mediated via ax-methylnoradrenaline acting at central ea-adrenoceptors. The hypotensive action of a-methyldopa has also been found to be antagonized by central ea-adrenoceptor blockade, adrenergic uptake or 6-hydroxydopamine treatment in animals (Finch & Haeusler, 1973;Kale & Satoskar, 1970) and by tricycic antidepressant treatment in man (White, 1965).…”

Section: Discussionmentioning

confidence: 99%

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Studies on the Hypotensive Action of Α‐methyldopamine

Finch

Hersom

Hicks

1975

British J Pharmacology

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I Intraventricular a-methyldopamine (50-200 gg) produced a dose-related fall in blood pressure in conscious spontaneously hypertensive rats. Pretreatment with intraventricular 6-hydroxydopamine prevented this hypotensive effect of a-methyldopamine. 2 The hypotensive effect of a-methyldopamine was prevented by intraventricular injection of phentolamine or desmethylimipramine, but not by intraperitoneal injection of haloperidol.3 Pretreatment with U-14,624, a selective central dopamine-4-hydroxylase inhibitor, prevented the hypotensive effect of a-methyldopamine. 4 cx-Methyldopamine was considerably less potent than noradrenaline as a pressor agent in the pithed rat, but noradrenaline and cx-methylnoradrenaline were found to be equipotent. 5 a-Methyldopamine (1-5 mg i.c.v.) reduced pressor responses elicited by electrical stimulation of the midbrain reticular formation in cats anaesthetized with chloralose. 6 It is concluded that the hypotensive action of ca-methyldopamine in conscious animals involves intact central ca-adrenergic neurones and a central adrenergic uptake mechanism for the formation of a-methylnoradrenaline.

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Section: Discussionmentioning

confidence: 99%

“…The hypotensive action of a-methyldopa has also been found to be antagonized by central ea-adrenoceptor blockade, adrenergic uptake or 6-hydroxydopamine treatment in animals (Finch & Haeusler, 1973;Kale & Satoskar, 1970) and by tricycic antidepressant treatment in man (White, 1965).…”

Section: Discussionmentioning

confidence: 99%

Studies on the Hypotensive Action of Α‐methyldopamine

Finch

Hersom

Hicks

1975

British J Pharmacology

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“…In 1894, Ahlfeld mentioned that the disorder was due to the existence of specific toxins of pregnancy, which were produced in the placenta and thus it came to be called toxemia. According to ACOG, the diagnosis of Hypertension in pregnancy is made by any one of the following criteria [5,6] .  Systolic BP of 140 mm Hg or more.…”

Section: Introductionmentioning

confidence: 99%

Clinical profile of pregnant women with pregnancy induced hypertension

Jyothsna¹,

Prasanthi²

2020

Int. J. Clin. Obstet. Gynaecol.

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Multisystem disorders of unknown aetiology characterized by development of HTN to the extent of 140/90 mm Hg or more with Proteinuria after 20 th wk of pregnancy in a previously normotensive and non proteinuric patient. May appear before 20wks in cases of hydatidiform mole, acute polyhydramnios and multiple pregnancies. BP≥ 140/90 mm Hg before pregnancy or diagnosed before 20 weeks gestation not attributable to gestational trophoblastic disease (OR) Hypertension first diagnosed after 20 weeks gestations and persistent after 12 weeks postpartum. In chronic HTN, the foetus is more prone for growth restriction, preterm delivery, and death of foetus. 50% of the cases belong to The Labetalol Group, while the other 50% comprise The Nifedipine Group, selected randomly. Each group comprised a total of 62 cases, 50 of them are Mild PIH cases while the other 12 cases are the cases of Severe Hypertension, Imminent Eclampsia, Eclampsia, Placental Abruption etc. Most of the cases of Labetalol Group progressed up to term, of which one case crossed the EDD. This woman was discharged at her request and she reported to the hospital only after crossing the EDD. As many as 69.35% (43 cases) delivered vaginally in Labetalol Group, whereas the Caesarean section rate for Nifedipine group is about 48.39%. Emergency Caesarean section rate was 25.80% in Labetalol group where as it was 37.10% in the Nifedipine Group.

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Sympathetic Nervous System and Hypertension

Thoenen¹

1974

Achtzigster Kongress

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Modification of the central hypotensive effect of α-methyldopa by reserpine, imipramine and tranylcypromine

Cited by 4 publications

References 19 publications

Studies on the Hypotensive Action of Α‐methyldopamine

Studies on the Hypotensive Action of Α‐methyldopamine

Clinical profile of pregnant women with pregnancy induced hypertension

Sympathetic Nervous System and Hypertension

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