Modification of fast release fluoride varnish by addition of plant-based extracts as antibacterial agents

Geraldine, Karen; Putriani, Dhea; Eriwati, Yosi Kusuma; Hermansyah, Heri

doi:10.1063/5.0047551

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…Several researchers stated that some medicinal plants extract may contain secondary metabolites like essential oils, flavonoids, alkaloids, triterpenoids, and phenolic compounds which can be effective against S. mutans, a microorganism involved in the development of dental caries. [2][3][4]10,11,15 The variations in chemical structure and molecular weight for each compound might be the cause of the different antibacterial effects. The amount of hydroxyl groups and the length of the hydrocarbon chain vary among aromatic hydrocarbons.…”

Section: Discussionmentioning

confidence: 99%

“…2021 4 (In vitro study) Fluoride varnish formulation using addition of LorAnn Oils flavor oils with the flavors strawberry-kiwi, cinnamon roll, and marshmallow, and also natural antibacterial agents from extracts of pomegranate (Punica granatum) fruit, betle (Piper crocatum) leaves, and soursop (Annona muricata) leaves to inhibit Streptococcus mutans.…”

Section: Geraldine Et Almentioning

confidence: 99%

“…In addition, flavoring oil and antibacterial agents were also reported to increase the rate of release of fluoride ions from FV. 4 Lately, FV is fabricated with the aim of preventing the growth of bacteria that can cause dental caries, such as chlorhexidine and silver diamine. 5,6 Despite adding antibacterial properties, several studies claimed that it should not be used for extended periods of time since it can cause unpleasant side effects including discoloration of teeth, mucosal peeling, and altered taste.…”

Section: Introductionmentioning

confidence: 99%

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Fluoride Varnish with Antibacterial Agents for Dental Caries Prevention: A Short Review on Its Fabrication

Cendikiawan,

Eriwati

2023

J Indones Dent Assoc

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Introduction: In recent years, the medical field has begun to use medicinal plant in the manufacture of modern medicines. Most of the medicinal plants used have antibacterial properties such as cinnamon, clove, betel, and holy basil. These medicinal plants could be used in the manufacture of fluoride varnish to support antibacterial properties in preventing the development of dental caries. Objective: This study aimed to provide update review of medicinal plant used as antibacterial agent in the fabrication of fluoride varnish to prevent dental caries. Method: Data collection were carried out by searching the literature on article search sites, namely PubMed and Scopus which were published from 2017 to 2022. Data searches were carried out systematically using the keywords fluoride varnish, dental caries, antibacterial, and fabrication. The author performs data search, data selection, and data extraction. Results: Only nine articles were found after a thorough selection process and database search using search terms and keywords. Seven of the studies were in vitro study and two was randomized clinical trial (RCT). In the overall fluoride varnish efficacy study, adding medicinal plant as an antibacterial agent showed strong antibacterial action against S. mutans with great bacterial inhibition zone. Together with its constituent parts, the fabricating method, such as the temperature and stirring rate, influence the optimal result of fluoride varnish. Conclusion: The addition of medicinal plants and method modification in the fabrication of fluoride varnish showed potential antibacterial properties that enhance higher fluoride release.

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Section: Discussionmentioning

confidence: 99%

Section: Geraldine Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fluoride Varnish with Antibacterial Agents for Dental Caries Prevention: A Short Review on Its Fabrication

Cendikiawan,

Eriwati

2023

J Indones Dent Assoc

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“…At the lowest concentration (0.1%), the inhibition zone reaches 9.9 mm, and at the highest concentration (100%), it reaches 26.79 mm [10]. Another research on fluoride varnishes combined with plant-based extracts also shows that fluoride varnish containing 0.01 g/mL red betel leaves extracts results in 4.59 mm-wide inhibition zone against Streptococcus mutans compared to fluoride varnish without plant-based extracts [11].…”

Section: Introductionmentioning

confidence: 95%

Growth Inhibition of Streptococcus mutans by Fluoride Varnish Containing Averrhoa bilimbi L. and Piper crocatum Leaves Extracts

Gabriella

Eriwati

Hermansyah

2022

AMM

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Fluoride varnish is commonly used as topical fluoride therapy to prevent dental caries. Dental caries is a dissolution of tooth surface caused by the metabolic activity of Streptococcus mutans in the presence of carbohydrates. Fluoride varnishes containing antibacterial agents significantly affect the inhibition zone of Streptococcus mutans. Prior studies also note the inhibitory effect of wuluh starfruit (Averrhoa bilimbi L.) leaves extracts and fast release fluoride varnish containing red betel (Piper crocatum) leaves extracts on Streptococcus mutans. The purpose of this study was to evaluate the antibacterial effect of adding wuluh starfruit leaves extracts, and red betel leaves extracts to a formulation of fluoride varnish on the growth inhibition of Streptococcus mutans, the fluoride ion release, and the pH obtained from the fluoride varnish. The concentration of antibacterial extracts used was 0.1 g/mL each and MI Varnish served as control. The growth inhibition zone of Streptococcus mutans was measured using disk-diffusion agar method with 3 repetitions. The data produced were analyzed using the Kruskal-Wallis and Mann-Whitney U-tests. Fluoride varnishes containing antibacterial agents used in this study resulted in greater inhibition zone of Streptococcus mutans than control (P < 0.05). The addition of red betel leaves extracts resulted in greater mean diameter of inhibition zone (14.22 mm) than that of wuluh starfruit leaves extracts (13.75 mm), but there was no significant difference (P > 0.05). The fluoride ion release of fluoride varnish containing red betel leaves extracts and wuluh starfruit leaves extracts after 360 minutes is 269.08 mg/L and 229.32 mg/L, respectively. The pH of both fluoride varnishes is above the critical pH of hydroxyapatite. Thus, wuluh starfruit leaves extracts, and red betel leaves extracts have the potential to be used as one of the ingredients in the formulation of fluoride varnish to achieve better growth inhibition of Streptococcus mutans.

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Modification of fast release fluoride varnish by addition of plant-based extracts as antibacterial agents

Cited by 2 publications

References 6 publications

Fluoride Varnish with Antibacterial Agents for Dental Caries Prevention: A Short Review on Its Fabrication

Fluoride Varnish with Antibacterial Agents for Dental Caries Prevention: A Short Review on Its Fabrication

Growth Inhibition of <i>Streptococcus mutans</i> by Fluoride Varnish Containing <i>Averrhoa bilimbi </i>L<i>.</i> and <i>Piper crocatum</i> Leaves Extracts

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