Modifiable lifestyle factors and ovarian cancer incidence in women

Abstract

Introduction. A correct diet plays an important role in the prevention of malignant tumours. The risk of the disease may be reduced by introducing a number of changes to the daily diet. The most important changes concern the amount of fat in the diet, dietary fibre, antioxidants in the food and the reduction of substances having a significant impact on the development of malignant tumours. Objective. The aim of the study is to analyse the role of selected modifiable lifestyle factors affecting the development of ovarian cancer. Materials and method. The study covered healthy women and women with diagnosed ovarian cancer. A total of 850 women aged between 21-84 were studied. The study included women visiting the Gynaecology and Obstetrics Hospital of the University of Medical Sciences in Poznan, Poland, between 2011-2013. Patients recognized with malignant ovarian cancer were qualified into the study based on the histopathological examination of the material obtained during surgery. Results.Respondents who consumed fruit and vegetables several times a week have the odds ratio OR = 0.29 level; 95% CI 0.04-2.01 (p =.2085), compared to women not consuming fruit and vegetables at all. Consumption of 100 g of French fries and potato chips several times a week, results in a 2-fold increase in ovarian cancer. The OR for this group of women amounts to 2.06; 95% CI 0.53-7.99 (p=.2966). Conclusions. A diet rich in fruit and vegetables, including bulb vegetables, and grain products containing whole grains, should be introduced. It is recommended that the consumption of popular fast foods be eliminated.

Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

“…Olive oil consumption, the richest food source of tyrosols [ 8 ], was inversely associated with EOC risk in an Italian case-control study [ 35 ]. Similar protective results were found for whole grain cereals, the main food sources of alkylphenols [ 8 ], in a Polish case-control study [ 36 ]. Recall bias is a well-established drawback of case-control studies, especially to investigate dietary factors, and therefore further prospective studies are needed to evaluate the relationships with the intake of minor polyphenol subclasses.…”

Risk Factors for Ovarian Cancer

“…Diet may be modifying the risk of ovarian cancer through effect on endogenous hormones, antioxidant activity or other anticarcinogenic mechanisms. There is however a unanimous finding of reduced incidence of ovarian cancer with higher intake of vegetables especially for epithelial ovarian cancer [106][107][108][109][110][111]. The average finding is a reduction of risk by about more than 50%.…”

Lifestyle with particular emphasis on physical activity and genital carcinomas in women

“…Vigorous physical effort may contribute to delay in menarche, irregular menstruation cycles, and primary or secondary amenorrhea. Furthermore, production of steroid hormonebinding globulins increases, which in turn reduces estrogenic activity [13][14][15][16][17].…”