Moderation of Arabidopsis Root Stemness by CLAVATA1 and ARABIDOPSIS CRINKLY4 Receptor Kinase Complexes

Stahl, Yvonne; Grabowski, Stephanie; Bleckmann, Andrea; Kühnemuth, Ralf; Weidtkamp‐Peters, Stefanie; Pinto, Karine Gustavo; Kirschner, Gwendolyn K; Schmid, Júlia; Wink, René H.; Hülsewede, Adrian; Felekyan, Suren; Seidel, Claus A. M.; Simon, Rüdiger

doi:10.1016/j.cub.2013.01.045

Cited by 337 publications

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“…There are several parallel signaling pathways involved in root stem cell niche maintenance, such as SHR-SCR [46][47][48][49][50], CLE40-ACR4/CLV1-WOX5 [19,20], and RGF1-PLT pathways [25,30,51,52]. To examine which pathway was mainly affected in the quintuple mutant, The expression levels and patterns of both SHR and SCR are not significantly altered in the quintuple mutant compared with the wild-type plant (Supplementary information, Figure S3A and S3B), which is consistent with root cross section results, showing that there are no obvious cell differentiation defects in the quintuple mutant (Supplementary information, Figure S1C).…”

Section: Expression Levels Of Plt1 and Plt2 Were Greatly Downregulatementioning

confidence: 99%

“…CLV3 is perceived by three different receptors or putative receptors, CLAVA-TA1 (CLV1), CLAVATA 2 (CLV2)-CORYNE (CRN), and RPK2/TOAD2, to limit stem cell size by restricting the expression of a homeodomain transcription factor, WUSCHEL (WUS), via a negative feedback loop [13][14][15][16][17][18]. On the other hand, CLE40 is perceived by its putative receptor complex containing two different RLKs, ARA-BIDOPSIS CRIKLY4 (ACR4) and CLV1, to inhibit the expression of a root version of homeodomain transcription factor, WOX5 [19,20]. TRACHEARY ELEMENT DIFFERENTIATION INHIBITORY FACTOR (TDIF)/ CLE41/CLE44 peptide regulates vascular development in Arabidopsis.…”

Section: Introductionmentioning

confidence: 99%

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RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana

et al. 2016

Cell Res

152

174

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Section: Expression Levels Of Plt1 and Plt2 Were Greatly Downregulatementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana

et al. 2016

Cell Res

152

174

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“…S1A). Several plant hormones and proteins that play a role in this process have been identified, and small regulatory networks have been proposed (3)(4)(5)(6)(7)(8)(9)(10)(11). However, our knowledge of the mechanisms and signaling networks mediating formative cell divisions is sparse and is largely derived from transcriptional data (12).…”

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confidence: 99%

“…Reversible protein phosphorylation represents a major mechanism regulating cell signaling (13), and several kinases have been shown to play a role in primary root development (5,6,14). For example, the evolutionarily conserved plasma membrane-localized receptor-like kinase ARABIDOPSIS CRINKLY 4 (ACR4) marks the plasma membrane in the primary root tip columella and is part of a mechanism controlling formative cell divisions in the Arabidopsis root (5,6,15).…”

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confidence: 99%

“…For example, the evolutionarily conserved plasma membrane-localized receptor-like kinase ARABIDOPSIS CRINKLY 4 (ACR4) marks the plasma membrane in the primary root tip columella and is part of a mechanism controlling formative cell divisions in the Arabidopsis root (5,6,15). ACR4 possesses an extracellular ligand-binding domain, a transmembrane helix, and an intracellular domain that contains the juxtamembrane and the C-terminal subdomains, which flank the core kinase domain with serine/threonine kinase activity (Fig.…”

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PP2A-3 interacts with ACR4 and regulates formative cell division in the Arabidopsis root

Yue

Sandal

Williams

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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In plants, the generation of new cell types and tissues depends on coordinated and oriented formative cell divisions. The plasma membrane-localized receptor kinase ARABIDOPSIS CRINKLY 4 (ACR4) is part of a mechanism controlling formative cell divisions in the Arabidopsis root. Despite its important role in plant development, very little is known about the molecular mechanism with which ACR4 is affiliated and its network of interactions. Here, we used various complementary proteomic approaches to identify ACR4-interacting protein candidates that are likely regulators of formative cell divisions and that could pave the way to unraveling the molecular basis behind ACR4-mediated signaling. We identified PROTEIN PHOSPHATASE 2A-3 (PP2A-3), a catalytic subunit of PP2A holoenzymes, as a previously unidentified regulator of formative cell divisions and as one of the first described substrates of ACR4. Our in vitro data argue for the existence of a tight posttranslational regulation in the associated biochemical network through reciprocal regulation between ACR4 and PP2A-3 at the phosphorylation level.stem cells | columella | phosphorylation | kinase | phosphatase

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Plasmodesmata

Faulkner

Oparka

2016

Encyclopedia of Life Sciences

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Plasmodesmata are plasma membrane‐lined pores that span the adjoining walls of plant cells. They permit the intercellular passage of molecules and signals and play a central role in plant physiology and development. Evidence suggests that small molecules can pass from cell to cell by passive diffusion and that this is controlled by regulation of the pore itself. This contributes to processes such as the transport of sugars between cells and tissues. Many endogenous plant proteins and ribonucleic acid (RNA)‐based signals also utilise plasmodesmata for cell‐to‐cell and long‐distance movement. Recent data suggests that plasmodesmata are tightly controlled during development and in response to environmental changes. There is increasing evidence that this regulation is controlled by proteins that have specific plasmodesmata‐associated functions in stimulus perception and signalling. In addition, many viruses exploit plasmodesmata for cell‐to‐cell spread during infection and their encoded viral movement proteins manipulate the pores to facilitate this process. Key Concepts Plant cells are connected to each other by cytoplasmic bridges called plasmodesmata. The continuous interconnected cytoplasm in plants is referred to as the symplasm. A tube of endoplasmic reticulum passes through plasmodesmata and connects the endoplasmic reticulum of neighbouring cells, thus providing endomembrane continuity between cells. Primary plasmodesmata are formed at cytokinesis when strands of endoplasmic reticulum are trapped between fusing vesicles in the developing cell wall. Secondary plasmodesmata are formed across existing cell walls, including those at graft unions, and usually arise immediately adjacent to existing plasmodesmata. Molecules smaller than the size exclusion limit (SEL) of plasmodesmata are able to move freely through the cytoplasmic channel of plasmodesmata by simple diffusion. The SEL of plasmodesmata may increase or decrease to allow changes in plasmodesmatal conductance. This may occur under different conditions, for example, in response to intracellular factors such as cytoplasmic calcium levels or pathogen perception. Some endogenous proteins and some movement proteins encoded by plant viruses are able to increase the SEL of plasmodesmata to facilitate their own passage into neighbouring cells. This enables these proteins to function in cells in which they are not normally expressed. Groups of cells may be connected by plasmodesmata that share an SEL different to that of neighbouring cells. These regions of cells are called symplasmic domains. Some proteins and RNA molecules pass into the plant's translocation stream and move over long distances. These macromolecules traffic through the plasmodesmata that join sieve elements (SE) and companion cells within the phloem. These macromolecules may have a site of action distant to their site of expression and synthesis.

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Moderation of Arabidopsis Root Stemness by CLAVATA1 and ARABIDOPSIS CRINKLY4 Receptor Kinase Complexes

Cited by 337 publications

References 50 publications

RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana

RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana

PP2A-3 interacts with ACR4 and regulates formative cell division in the Arabidopsis root

Plasmodesmata

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