Moderate Wine Consumption Is Associated with Decreased Odds of Developing Age‐Related Macular Degeneration in NHANES‐1

Obisesan, Thomas O.; Hirsch, Robert; Kosoko, Omofolasade; Carlson, Letitia; Parrott, Marian

doi:10.1111/j.1532-5415.1998.tb01005.x

Cited by 149 publications

(62 citation statements)

References 40 publications

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“…On the other hand, many studies have revealed that alcohol consumed in smaller amounts may protect from several non-autoimmune diseases such as ischemic heart disease (1), cerebral thrombosis (2), hypertension (3), upper respiratory infections (4), gallbladder and renal stones (5,6), age-related macular degeneration (7), and dementia (8). Recently, it was shown that asthma incidence is also lower among moderate alcohol consumers compared with abstainers (9).…”

Section: Introductionmentioning

confidence: 99%

Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

Carlé

Pedersen

Knudsen

et al. 2012

European Journal of Endocrinology

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ObjectiveAlcohol consumption is an important protective risk factor for many autoimmune diseases. We wished to study the association between alcohol consumption and autoimmune hypothyroidism.DesignPopulation-based, case–control study, 1997–2001, Denmark.MethodsPatients with newly diagnosed autoimmune overt hypothyroidism (n=140) were prospectively identified in a population (2 027 208 person-years of observation), and their matched controls with normal thyroid function (n=560) were recruited simultaneously from the same population. Participants gave information on alcohol intake, smoking, previous diseases, education, and family history of hypothyroidism. The association between alcohol intake and development of hypothyroidism was analyzed in conditional regression models.ResultsHypothyroid cases had reported a lower alcohol consumption than controls (median units of alcohol (12 g) per week: 3 vs 5,P=0.002). In a multivariate regression model, alcohol consumption was associated with a reduction in risk for development of overt autoimmune hypothyroidism. Odds ratios (95% confidence interval) compared with the reference group with a recent (last year) consumption of 1–10 units of alcohol per week were as follows: 0 units/week, 1.98 (1.21–3.33); 11–20 units/week, 0.41 (0.20–0.83); and ≥21 units/week, 0.90 (0.41–2.00). Similar results were found for maximum previous alcohol consumption during a calendar year. No interaction was found with type of alcohol consumed (wine vs beer), sex, or region of inhabitancy.ConclusionsAlcohol consumption seems to confer considerable protection against development of overt autoimmune hypothyroidism irrespective of sex and type of alcohol consumed.

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Section: Introductionmentioning

confidence: 99%

Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

Carlé

Pedersen

Knudsen

et al. 2012

European Journal of Endocrinology

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“…Moderate drinking is associated with a decreased risk of myocardial infarction, stroke, and cardiac death (1,2), as well as macular degeneration, Alzheimer's disease, and cognitive deficits (3)(4)(5)(6)(7). Although the benefits of alcohol consumption are partially related to its ability to increase high-density lipoprotein (HDL)-cholesterol and to inhibit platelets, some studies indicate that the greatest protection is due to red wine (RW), rather than beer or spirits (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients

Coimbra

Lage

Brandizzi

et al. 2005

Braz J Med Biol Res

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Although red wine (RW) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. Correction of endothelial dysfunction by RW flavonoids could be one mechanism. We measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesion molecules (ICAM-1 and VCAM), and platelet function in 16 hypercholesterolemic individuals (8 men and 8 women; mean age 51.6 ± 8.1 years) without other risk factors. Twenty-four normal subjects were used as controls for vascular reactivity. Subjects randomly received RW, 250 ml/day, or purple grape juice (GJ), 500 ml/day, for 14 days with an equal wash-out period. At baseline, all 16 subjects were hypercholesterolemic (mean LDL = 181.0 ± 28.7 mg/dl) but HDL, triglycerides, glucose, adhesion molecules, and platelet function were within normal limits. Brachial artery flow-mediated dilation was significantly decreased compared to controls (9.0 ± 7.1 vs 12.1 ± 4.5%; P < 0.05) and increased with both GJ (10.1 ± 7.1 before vs 16.9 ± 6.7% after: P < 0.05) and RW (10.1 ± 6.4 before vs 15.6 ± 4.6% after; P < 0.05). RW, but not GJ, also significantly increased endothelium-independent vasodilation (17.0 ± 8.6 before vs 23.0 ± 12.0% after; P < 0.01). GJ reduced ICAM-1 but not VCAM and RW had no effect on either molecule. No significant alterations were observed in plasma lipids, glucose or platelet aggregability with RW or GJ. Both RW and GJ similarly improved flow-mediated dilation, but RW also enhanced endothelium-independent vasodilation in hypercholesterolemic patients despite the increased plasma cholesterol. Thus, we conclude that GJ may protect against coronary artery disease without the additional negative effects of alcohol despite the gender.

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“…36 The authors of this report speculated that antioxidant phenolic compounds found in high concentrations in red wine may explain their finding. In Beaver Dam, wine consumption was associated with a reduction in the 15-year incidence of early AMD; however, the association did not reach statistical significance.…”

Section: Alcoholmentioning

confidence: 83%

Lifestyle Exposures and Eye Diseases in Adults

Klein

2007

American Journal of Ophthalmology

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Purpose-To provide a perspective of observed associations between lifestyle exposures and eye diseases in adults. Design-Summary of recent epidemiologic studies.Methods-Non-systematic review of the literature.Results-Data suggest that some lifestyle exposures (e.g., smoking) are significantly associated with risk of several different diseases, suggesting that altering behaviors may decrease risk. Where risk is inherent to an occupational or recreational activity, eye protection is likely to decrease risk.Conclusions-Although data are imperfect, it seems that some lifestyle alterations may decrease the risk of eye diseases at little or not risk to the individual. Keywordsepidemiology; lifestyle; risk factors; age-related macular degeneration; cataract; diabetic retinopathy Lifestyle exposures or behaviors have been linked to many human illnesses. Examples are wide ranging from the observation of the association of lung cancer with smoking to food-borne parasitic infection due to ingesting raw or partially cooked shellfish containing parasites (e.g., paragonimus metacercariae). Other examples are common in chronic and infectious disease epidemiology. The best way to establish the efficacy of a preventive (or causative) exposure for a disease outcome, whether a drug, device, or behavior (lifestyle), is to evaluate the effect in a well-designed randomized, masked, controlled clinical trial. However this is often not feasible when examining the relationship of lifestyle exposures with disease, where observational studies may be the only methodology available. Even though observational studies may add important information on the effectiveness of interventions in the community, investigators involved in such studies must be aware of self-selection and confounding inherent in such studies and should attempt to investigate and adjust for these (e.g., by calculating a propensity score).Assessing relationships from observational data is complicated by varying exposure 'doses' over the previous life course and by interacting lifestyle exposures (omitting the ever complicating genetic factors). In addition, documentation of the exposures usually depends almost entirely on self report. This may be complicated by inaccurate memory, by deliberate Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptAm J Ophthalmol. Author manuscript; available in PMC 2008 December 1. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript over or under estimation of the exposure under investigation, and by non-random exposure. Nevertheless, import...

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Moderate Wine Consumption Is Associated with Decreased Odds of Developing Age‐Related Macular Degeneration in NHANES‐1

Cited by 149 publications

References 40 publications

Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients

Lifestyle Exposures and Eye Diseases in Adults

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