Moderate exercise combined with metformin-treatment improves mitochondrial bioenergetics of the quadriceps muscle of old female Wistar rats

López-Cervantes, Stefanie Paola; Sánchez, Norma Silvia; Calahorra, Martha; Mena-Montes, Beatriz; Pedraza-Vázquez, Gibrán; Hernández-Álvarez, David; Esparza-Perusquía, Mercedes; Peña, Antonio; López‐Díazguerrero, Norma Edith; Alarcón-Aguilar, Adriana; Luna–López, Armando; Flores-Herrera, Óscar; Königsberg, Mina

doi:10.1016/j.archger.2022.104717

Cited by 4 publications

(3 citation statements)

References 67 publications

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“…Meanwhile, the effective way to deliver drugs specifically to mitochondria is by covalent linking a lipophilic cation such as an alkyltriphenylphosphonium moiety to a pharmacophore of interest [ 221 ]. The combination of metformin and exercise improves mitochondrial bioenergetics and has beneficial effects against muscle loss and fat accumulation by regulating redox status [ 222 ]. Moreover, Mito-Met (metformin conjugated with TPP +) can enhance the targeting of metformin [ 221 ].…”

Section: Therapeutic Strategies Targeting Mitochondria For Skeletal M...mentioning

confidence: 99%

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Chen¹,

Ji²,

Liu³

et al. 2023

J Transl Med

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Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can lead to skeletal muscle atrophy, and its molecular mechanism leading to skeletal muscle atrophy is complex. Understanding the pathogenesis of mitochondrial dysfunction is useful for the prevention and treatment of skeletal muscle atrophy, and finding drugs and methods to target and modulate mitochondrial function are urgent tasks in the prevention and treatment of skeletal muscle atrophy. In this review, we first discussed the roles of normal mitochondria in skeletal muscle. Importantly, we described the effect of mitochondrial dysfunction on skeletal muscle atrophy and the molecular mechanisms involved. Furthermore, the regulatory roles of different signaling pathways (AMPK-SIRT1-PGC-1α, IGF-1-PI3K-Akt-mTOR, FoxOs, JAK-STAT3, TGF-β-Smad2/3 and NF-κB pathways, etc.) and the roles of mitochondrial factors were investigated in mitochondrial dysfunction. Next, we analyzed the manifestations of mitochondrial dysfunction in muscle atrophy caused by different diseases. Finally, we summarized the preventive and therapeutic effects of targeted regulation of mitochondrial function on skeletal muscle atrophy, including drug therapy, exercise and diet, gene therapy, stem cell therapy and physical therapy. This review is of great significance for the holistic understanding of the important role of mitochondria in skeletal muscle, which is helpful for researchers to further understanding the molecular regulatory mechanism of skeletal muscle atrophy, and has an important inspiring role for the development of therapeutic strategies for muscle atrophy targeting mitochondria in the future.

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Section: Therapeutic Strategies Targeting Mitochondria For Skeletal M...mentioning

confidence: 99%

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Chen¹,

Ji²,

Liu³

et al. 2023

J Transl Med

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“…Studies provide evidence that WBV improves body composition and muscle strength ( Delecluse et al, 2003 ; Roelants et al, 2004 ; Prisby et al, 2008 ; Fontana et al, 2022 ). Furthermore, WBV enhances force and power in skeletal muscle, and at the molecular level, it leads to the formation of reactive oxygen species generation similar to that following treadmill exercise ( Lopez-Cervantes et al, 2022 ). The moderate level of reactive oxygen species generation confers muscular adaptation via mitochondrial biogenesis.…”

Section: Introductionmentioning

confidence: 99%

Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes

Kerr

Sanchez²,

Moreno³

et al. 2022

Front. Aging Neurosci.

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Low-frequency whole-body vibration (WBV; 40 Hz), a low impact form of exercise, intervention for a month following moderate transient middle-cerebral artery occlusion (tMCAO) reduces infarct volume and improves motor function in reproductively senescent, middle-aged female rats. Since post-stroke cognitive decline remains a significant problem, the current study aims to investigate the efficacy of WBV in ameliorating post-tMCAO cognitive deficits and to determine the underlying putative mechanism(s) conferring benefits of WBV in middle-aged rats. Middle-aged rats of both sexes were randomly assigned to tMCAO (90 min) or sham surgery followed by exposure to either WBV (twice a day for 15 min each for 5 days a week over a month) or no WBV treatment groups. Following the last WBV treatment, rats were tested for hippocampus-dependent learning and memory using a water maze followed by harvesting brain and blood samples for histopathological and inflammatory marker analyses, respectively. Results show that post-tMCAO WBV significantly lessens cognitive deficits in rats of both sexes. Post-tMCAO WBV significantly decreased circulating pro-inflammatory cytokines and increased serum levels of irisin, a muscle-derived hormone that may play a role in brain metabolism and inflammation regulation, which suggests putative beneficial mechanisms of WBV.

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“…En el contexto del envejecimiento, los mecanismos moleculares durante el entrenamiento de resistencia se centran en el aumento de la capacidad antioxidante debido a la sobreexpresión de las enzimas catalasa y SOD2 (Johnson et al, 2015;López-Cervantes et al, 2022).…”

Section: El Ejercicio Y El Envejecimientounclassified

Efecto del ejercicio de baja intensidad en un modelo de obesidad osteosarcopénica y la regulación de la expresión de miRNAs durante el envejecimiento

Pedraza Vázquez

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El que suscribe Gibran Pedraza Vazquez alumno con número de matrícula 2143800973 del posgrado en Biología Experimental de la Universidad Autónoma Metropolitana, Unidad Iztapalapa (UAM-I), manifiesto mi compromiso de mantener de forma confidencial y de no utilizar, divulgar o difundir por ningún medio, en beneficio propio o de terceros, la información, la documentación y datos de toda índole a los que tenga acceso y reciba con motivo del proyecto de investigación "Efecto del ejercicio de baja intensidad en un modelo de obesidad osteosarcopénica y la regulación con la expresión de miRNAs durante el envejecimiento" a desarrollar en el

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Moderate exercise combined with metformin-treatment improves mitochondrial bioenergetics of the quadriceps muscle of old female Wistar rats

Cited by 4 publications

References 67 publications

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes

Efecto del ejercicio de baja intensidad en un modelo de obesidad osteosarcopénica y la regulación de la expresión de miRNAs durante el envejecimiento

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