Modelling Plasmid-Mediated Horizontal Gene Transfer in Biofilms
Julien Vincent,
Alberto Tenore,
Maria Rosaria Mattei
et al.
Abstract:In this study, we present a mathematical model for plasmid spread in a growing biofilm, formulated as a nonlocal system of partial differential equations in a 1-D free boundary domain. Plasmids are mobile genetic elements able to transfer to different phylotypes, posing a global health problem when they carry antibiotic resistance factors. We model gene transfer regulation influenced by nearby potential receptors to account for recipient-sensing. We also introduce a promotion function to account for trace meta… Show more
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