Modeling the transmission dynamics and control of hepatitis B virus in China

Zou, Lan; Zhang, Weinian; Ruan, Shigui

doi:10.1016/j.jtbi.2009.09.035

Cited by 169 publications

(147 citation statements)

References 21 publications

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“…It is estimated that 350 to 400 million people are chronically infected [2]. In China, the overall positive rate of hepatitis B surface antigen (HBsAg) is 7.18% [3], and annually approximately 300,000 individuals die from HBV-related diseases including HCC (40% to 50% of that of the entire world) [4]. Mother-to-child transmission of HBV leads to 80% to 90% chronic carriers [5].…”

Section: Introductionmentioning

confidence: 99%

A knowledge survey of obstetrics and gynecology staff on the prevention of mother-to-child transmission of hepatitis B virus

Dai

Zhou

et al. 2013

J Infect Dev Ctries

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Introduction: This survey was designed to investigate the knowledge awareness of obstetrics and gynaecology staff (Obs/Gyn staff) on the prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV). Methodology: Obs/Gyn staff from 21 of the 31 Chinese mainland provinces, who attended medical meetings or training classes from July to October 2011, were invited to complete a questionnaire regarding PMTCT of HBV. The questionnaire included the clinical implications of HBV serologic markers and PMTCT preventive measures for both pregnant women and infants. Results: A total of 828 questionnaires were distributed, 617 (74.5%) Obs/Gyn staff participated in the survey, and 559 (90.6%) questionnaires met the inclusion criteria. Overall, 90% of participants correctly determined the positive hepatitis B surface antigen (HBsAg) as infectious, but up to 27.5% mistakenly considered the presence of anti-HBe and/or anti-HBc with negative HBsAg as infectious. In total, 96.3% respondents knew that pregnant women should be screened for HBV infection, and 95.3% realized that infants of HBsAg-positive mothers should be injected with hepatitis B immunoglobulin and vaccine. On the other hand, with the available immunoprophylaxis, 13.8% participants mistakenly believed caesarean section may prevent HBV mother-to-child transmission, and only 13% correctly answered that newborns of HBsAg positive mothers may be breastfed. Conclusion: Obs/Gyn staff in China have mastered the strategies of HBV PMTCT, but there is obvious insufficiency in details of the application. Intensified efforts to train the Obs/Gyn staff are required to improve the current suboptimal medical service in HBV-exposed infants and to control mother-to-infant transmission of HBV.

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Section: Introductionmentioning

confidence: 99%

A knowledge survey of obstetrics and gynecology staff on the prevention of mother-to-child transmission of hepatitis B virus

Dai

Zhou

et al. 2013

J Infect Dev Ctries

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“…Regarding the numerical values for the parameters in the model (3) provided in [19,20], we see that β = 0.0121, µ = 0.00693, µ 1 = 0.002, ψ = 0.1, Λ ≈ 0.16, σ = 6/year, γ 1 = 4/year, and γ 2 = 0.025/year.…”

Section: ∂ T S(a T) = −∂ a S(a T) − µ(A)s(a T) + ψV(a T) − S(a Tmentioning

confidence: 97%

“…Furthermore, substituting w into the last equation in (19) leads to (13). The error of the approximation, (n,…”

Section: Formal Asymptotic Expansionmentioning

confidence: 99%

An age-structured model for the transmission dynamics of hepatitis B: asymptotic analysis

Massoukou¹,

Traore²

2017

Turk J Math

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In this paper, we consider the age-structured model for the transmission dynamics of Hepatitis B virus (HBV) proposed earlier in the article by Zou et al.: An age-structured model for transmission dynamics of hepatitis B. SIAM J Appl Math 2010; 70: 3121-3139, where a slight modification is made. We consider that the HBV infection processes act on a time scale different from that of the vital processes. Such a model becomes a multiple time scale model and thus it often can be significantly simplified by various asymptotic methods. We apply, as in the paper of Banasiak and M'pika Massoukou: A singularly perturbed age structured SIRS model with fast recovery. Disc Cont Dyn Sys 2014, a suitable technique of asymptotic analysis, based on the Chapman-Enskog procedure, which allows separation of scales and aggregation of variables.

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“…HBV infection remains a challenging global health problem, affecting more than two billion people worldwide [1]. There are still more than 350 million chronic HBV infection carriers worldwide, who face a lethal risk of developing hepatic decompensation, cirrhosis, and hepatocellular carcinoma (HCC) [2].…”

Section: Introductionmentioning

confidence: 99%

“…In China, the improvements in socioeconomic status and hygienic conditions, the introduction of general vaccination, as well as complete sterilization of medical instruments, have led to a decline in the prevalence of HBV infection [3]. However, it still remains as high as 7.18%, and 300,000 people die from HBV-related diseases annually, accounting for 40%-50% of HBV-related deaths worldwide [1,3]. It was estimated that even for residents with health insurance, the direct cost caused by HBV infection exceeded 40% of resident's disposable household income in China [4].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of hepatitis B surface antigen and hepatitis B e antigen among childbearing-age women in Mianyang, China

Wang

et al. 2015

J Infect Dev Ctries

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Introduction: Few studies have focused on hepatitis B virus (HBV) infection among childbearing-age women. This study explored hepatitis B surface antigen (HBsAg) seroprevalence and hepatitis B e antigen (HBeAg) seroprevalence and their associated factors among childbearingage women. Methodology: A cross-sectional, population-based study was conducted between June 2013 and October 2013 in Mianyang; women 15-49 years of age were enrolled using a multistage cluster sampling design. Participants completed questionnaires about demographic characteristics and potential factors associated with HBV infection, and provided blood samples for screening HBsAg and HBeAg. The analysis methods included descriptive statistics, Chi-square test, and multivariate logistic regression. Results: Among 62,007 childbearing-age women, 5.66% were HBsAg positive. The HBsAg seroprevalence rates were 7.28% in women 40-44 years of age, 7.0% in Fucheng women, 5.70% in Han women, 6.59% in married women, and 6.60% in agriculture workers. Multivariate models identified having HBsAg-positive family members, and having no self-reported immunization history to be positively associated with HBsAg positivity; being a healthcare worker was negatively associated with HBsAg positivity. Among 3,499 HBsAg-positive childbearingage women, 9.97% were HBeAg positive. The HBeAg seroprevalence rates were 46.54% in women 15-19 years of age, 10.82% in Fucheng women, 38.51% in single women, and 42.86% in students. Multivariate models identified living in Fucheng and younger age to be positively associated with HBeAg positivity. Conclusions: These findings could provide scientific evidence for the Chinese government to plan efficient health care services and prevention initiatives, and to allocate health resources reasonably for this population.

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Modeling the transmission dynamics and control of hepatitis B virus in China

Cited by 169 publications

References 21 publications

A knowledge survey of obstetrics and gynecology staff on the prevention of mother-to-child transmission of hepatitis B virus

A knowledge survey of obstetrics and gynecology staff on the prevention of mother-to-child transmission of hepatitis B virus

An age-structured model for the transmission dynamics of hepatitis B: asymptotic analysis

Seroprevalence of hepatitis B surface antigen and hepatitis B e antigen among childbearing-age women in Mianyang, China

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