Modeling the mechanics of tissue-engineered human heart valve leaflets

Driessen, Niels J. B.; Mol, Anita; Bouten, Cvc Carlijn; Baaijens, Fpt Frank

doi:10.1016/j.jbiomech.2006.01.009

Cited by 88 publications

(106 citation statements)

References 34 publications

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“…In this study, however, cultured heart valves needed to be sacrificed to estimate the applied strains afterward. 8,25 Numerical simulations indicated a relation between volumetric deformation and local tissue strains in the heart valve deformation range considered in this study. The relation was relatively insensitive to changes in material properties of the heart valve leaflets.…”

Section: Discussionmentioning

confidence: 62%

“…To test our hypothesis, a quasi-static numerical model of the heart valve leaflets 7,25 was applied to investigate the relation between volumetric deformation and local tissue strains in the leaflets. Furthermore, to study the influence of the model's input material parameters on this relation, a sensitivity analysis was performed.…”

Section: Numerical Modelmentioning

confidence: 99%

“…7,8 To investigate the influence of the model's input parameters on the relation between volumetric and local deformation, a parametric study was performed. The parameters were varied in a range to cover the experimental data ( Table 1).…”

Section: Simulationsmentioning

confidence: 99%

“…The mechanical properties, defined as the product of thickness and shear modulus, of the rubber leaflets was chosen in the range of tissue engineered human valve leaflets. 7,8 Their thickness was measured (t = 0.08 ± 0.005 mm) and the shear modulus was determined by performing uniaxial tensile tests (G 0 = 7.2 ± 0.2 MPa). These parameters and the heart valve geometry were used as input for the numerical model and a simulation was performed.…”

Section: Polyurethane Heart Valvementioning

confidence: 99%

“…A numerical model 7,25 is employed to relate volumetric deformation to local tissue strains in the heart valve leaflet. The measurement method was validated and a tissue engineering experiment was performed to demonstrate the feasibility of the measurement method in vitro.…”

Section: Introductionmentioning

confidence: 99%

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Real Time, Non-Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering

et al. 2008

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Abstract-In heart valve tissue engineering, most bioreactors try to mimic physiological flow and operate with a preset transvalvular pressure applied to the tissue. The induced deformations are unknown and can vary during culturing as a consequence of changing mechanical properties of the engineered construct. Real-time measurement and control of local tissue strains are desired to systematically study the effects of mechanical loading on tissue development and, consequently, to design an optimal conditioning protocol. In this study, a method is presented to assess local tissue strains in heart valve leaflets during culturing. We hypothesize that local tissue strains can be determined from volumetric deformation. Volumetric deformation is defined as the amount of fluid displaced by the deformed heart valve leaflets in a stented configuration, and is measured, noninvasively, using a flow sensor. A numerical model is employed to relate volumetric deformation to local tissue strains in various regions of the leaflets (e.g. belly and commissures). The flow-based deformation measurement method was validated and its functionality was demonstrated in a tissue engineering experiment. Tri-leaflet, stented heart valves were cultured in vitro and during mechanical conditioning, realistic values for volumetric and local deformation were obtained.

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Section: Discussionmentioning

confidence: 62%

Section: Numerical Modelmentioning

confidence: 99%

Section: Simulationsmentioning

confidence: 99%

Section: Polyurethane Heart Valvementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Real Time, Non-Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering

et al. 2008

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Developing a Clinically Relevant Tissue Engineered Heart Valve—A Review of Current Approaches

Nachlas

Davis

2017

Adv Healthcare Materials

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Tissue engineered heart valves (TEHVs) have the potential to address the shortcomings of current implants through the combination of cells and bioactive biomaterials that promote growth and proper mechanical function in physiological conditions. The ideal TEHV should be anti-thrombogenic, biocompatible, durable, and resistant to calcification, and should exhibit a physiological hemodynamic profile. In addition, TEHVs may possess the capability to integrate and grow with somatic growth, eliminating the need for multiple surgeries children must undergo. Thus, this review assesses clinically available heart valve prostheses, outlines the design criteria for developing a heart valve, and evaluates three types of biomaterials (decellularized, natural, and synthetic) for tissue engineering heart valves. While significant progress has been made in biomaterials and fabrication techniques, a viable tissue engineered heart valve has yet to be translated into a clinical product. Thus, current strategies and future perspectives are also discussed to facilitate the development of new approaches and considerations for heart valve tissue engineering.

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3D physiological model of the aortic valve incorporating small coronary arteries

Mohammadi

Cartier

Mongrain

2016

Numer Methods Biomed Eng

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The diseases of the coronary arteries and the aortic root are still the leading causes of mortality and morbidity worldwide. In this study, a 3D global fluid-structure interaction of the aortic root with inclusion of anatomically inspired small coronary arteries using the finite element method is presented. This innovative model allows to study the impact and interaction of root biomechanics on coronary hemodynamics and brings a new understanding to small coronary vessels hemodynamics. For the first time, the velocity profiles and shear stresses are reported in distal coronary arteries as a result of the aortic flow conditions in a global fluid-structure interaction model.

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Modeling the mechanics of tissue-engineered human heart valve leaflets

Cited by 88 publications

References 34 publications

Real Time, Non-Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering

Real Time, Non-Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering

Developing a Clinically Relevant Tissue Engineered Heart Valve—A Review of Current Approaches

3D physiological model of the aortic valve incorporating small coronary arteries

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