2010
DOI: 10.1186/1471-2407-10-346
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Abstract: BackgroundAneuploidy has long been recognized to be associated with cancer. A growing body of evidence suggests that tumorigenesis, the formation of new tumors, can be attributed to some extent to errors occurring at the mitotic checkpoint, a major cell cycle control mechanism that acts to prevent chromosome missegregation. However, so far no statistical model has been available quantify the role aneuploidy plays in determining cancer.MethodsWe develop a statistical model for testing the association between an…

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